Syntheses and Antitumor Activity of 2-Deoxyribofuranosides of 3-Deazaguanine

A. Mohsin Mian, Tasneem A. Khwaja

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Synthesis of 2-deoxyribofuranosides of 3-deazaguanine (IX-XII) has been achieved by a base-catalyzed ring closure of appropriate 2-deoxyribofuranosides of methyl 5(4)-(cyanomethyl)imidazole-4(5)-carboxalate (IV-VII). The separation of isomers and anomers were accomplished by column chromatography and HPLC. The site of glycosidic linkage and the anomeric configurations were established on the basis of C-13 and proton magnetic resonance spectroscopy, as well as UV absorption characteristics. Preliminary results of the antitumor activity of these derivatives, in vitro and in vivo, are described.

Original languageEnglish (US)
Pages (from-to)286-291
Number of pages6
JournalJournal of Medicinal Chemistry
Issue number2
StatePublished - Feb 1983

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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