Synovial sarcoma of the vulva: A report of two cases

Gunnlaugur P. Nielsen, Patricia A. Shaw, Andrew Rosenberg, G. Richard Dickersin, Robert H. Young, Robert E. Scully

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We report two cases of synovial sarcoma arising in the vulva. The patients were 30 and 37 years old and presented with a painless mass that was interpreted clinically as a cyst. The tumors were 2.0 and 1.2 cm in greatest diameter. Histologically, they were composed of epithelial cells forming solid nests and gland-like and papillary structures surrounded by spindle-shaped cells. Immunohistochemically, the epithelial cells stained for cytokeratin and the spindle-shaped cells for vimentin. Ultrastructurally, the epithelial cells had prominent intercellular junctions and narrow microvilli and were separated from the spindle-shaped cells by a basal lamina. The spindle-shaped cells were closely apposed with focal intercellular contacts. One tumor recurred locally 3.5 years after excision, but the patient was alive and well 1 year after a re-excision and radiation therapy. The other patient was alive and well 4 years after an excision. These tumors are the first reported examples of synovial sarcoma arising in the vulva.

Original languageEnglish
Pages (from-to)970-974
Number of pages5
JournalModern Pathology
Volume9
Issue number10
StatePublished - Oct 1 1996
Externally publishedYes

Fingerprint

Synovial Sarcoma
Vulva
Epithelial Cells
Neoplasms
Focal Adhesions
Intercellular Junctions
Vimentin
Microvilli
Keratins
Basement Membrane
Cysts
Radiotherapy

Keywords

  • Synovial sarcoma
  • Vulva

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nielsen, G. P., Shaw, P. A., Rosenberg, A., Dickersin, G. R., Young, R. H., & Scully, R. E. (1996). Synovial sarcoma of the vulva: A report of two cases. Modern Pathology, 9(10), 970-974.

Synovial sarcoma of the vulva : A report of two cases. / Nielsen, Gunnlaugur P.; Shaw, Patricia A.; Rosenberg, Andrew; Dickersin, G. Richard; Young, Robert H.; Scully, Robert E.

In: Modern Pathology, Vol. 9, No. 10, 01.10.1996, p. 970-974.

Research output: Contribution to journalArticle

Nielsen, GP, Shaw, PA, Rosenberg, A, Dickersin, GR, Young, RH & Scully, RE 1996, 'Synovial sarcoma of the vulva: A report of two cases', Modern Pathology, vol. 9, no. 10, pp. 970-974.
Nielsen GP, Shaw PA, Rosenberg A, Dickersin GR, Young RH, Scully RE. Synovial sarcoma of the vulva: A report of two cases. Modern Pathology. 1996 Oct 1;9(10):970-974.
Nielsen, Gunnlaugur P. ; Shaw, Patricia A. ; Rosenberg, Andrew ; Dickersin, G. Richard ; Young, Robert H. ; Scully, Robert E. / Synovial sarcoma of the vulva : A report of two cases. In: Modern Pathology. 1996 ; Vol. 9, No. 10. pp. 970-974.
@article{68cdc59405644f6bad5fee7e189b355d,
title = "Synovial sarcoma of the vulva: A report of two cases",
abstract = "We report two cases of synovial sarcoma arising in the vulva. The patients were 30 and 37 years old and presented with a painless mass that was interpreted clinically as a cyst. The tumors were 2.0 and 1.2 cm in greatest diameter. Histologically, they were composed of epithelial cells forming solid nests and gland-like and papillary structures surrounded by spindle-shaped cells. Immunohistochemically, the epithelial cells stained for cytokeratin and the spindle-shaped cells for vimentin. Ultrastructurally, the epithelial cells had prominent intercellular junctions and narrow microvilli and were separated from the spindle-shaped cells by a basal lamina. The spindle-shaped cells were closely apposed with focal intercellular contacts. One tumor recurred locally 3.5 years after excision, but the patient was alive and well 1 year after a re-excision and radiation therapy. The other patient was alive and well 4 years after an excision. These tumors are the first reported examples of synovial sarcoma arising in the vulva.",
keywords = "Synovial sarcoma, Vulva",
author = "Nielsen, {Gunnlaugur P.} and Shaw, {Patricia A.} and Andrew Rosenberg and Dickersin, {G. Richard} and Young, {Robert H.} and Scully, {Robert E.}",
year = "1996",
month = "10",
day = "1",
language = "English",
volume = "9",
pages = "970--974",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - Synovial sarcoma of the vulva

T2 - A report of two cases

AU - Nielsen, Gunnlaugur P.

AU - Shaw, Patricia A.

AU - Rosenberg, Andrew

AU - Dickersin, G. Richard

AU - Young, Robert H.

AU - Scully, Robert E.

PY - 1996/10/1

Y1 - 1996/10/1

N2 - We report two cases of synovial sarcoma arising in the vulva. The patients were 30 and 37 years old and presented with a painless mass that was interpreted clinically as a cyst. The tumors were 2.0 and 1.2 cm in greatest diameter. Histologically, they were composed of epithelial cells forming solid nests and gland-like and papillary structures surrounded by spindle-shaped cells. Immunohistochemically, the epithelial cells stained for cytokeratin and the spindle-shaped cells for vimentin. Ultrastructurally, the epithelial cells had prominent intercellular junctions and narrow microvilli and were separated from the spindle-shaped cells by a basal lamina. The spindle-shaped cells were closely apposed with focal intercellular contacts. One tumor recurred locally 3.5 years after excision, but the patient was alive and well 1 year after a re-excision and radiation therapy. The other patient was alive and well 4 years after an excision. These tumors are the first reported examples of synovial sarcoma arising in the vulva.

AB - We report two cases of synovial sarcoma arising in the vulva. The patients were 30 and 37 years old and presented with a painless mass that was interpreted clinically as a cyst. The tumors were 2.0 and 1.2 cm in greatest diameter. Histologically, they were composed of epithelial cells forming solid nests and gland-like and papillary structures surrounded by spindle-shaped cells. Immunohistochemically, the epithelial cells stained for cytokeratin and the spindle-shaped cells for vimentin. Ultrastructurally, the epithelial cells had prominent intercellular junctions and narrow microvilli and were separated from the spindle-shaped cells by a basal lamina. The spindle-shaped cells were closely apposed with focal intercellular contacts. One tumor recurred locally 3.5 years after excision, but the patient was alive and well 1 year after a re-excision and radiation therapy. The other patient was alive and well 4 years after an excision. These tumors are the first reported examples of synovial sarcoma arising in the vulva.

KW - Synovial sarcoma

KW - Vulva

UR - http://www.scopus.com/inward/record.url?scp=0029858599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029858599&partnerID=8YFLogxK

M3 - Article

C2 - 8902833

AN - SCOPUS:0029858599

VL - 9

SP - 970

EP - 974

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 10

ER -