Synovial sarcoma of the vulva: A report of two cases

Gunnlaugur P. Nielsen, Patricia A. Shaw, Andrew E. Rosenberg, G. Richard Dickersin, Robert H. Young, Robert E. Scully

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

We report two cases of synovial sarcoma arising in the vulva. The patients were 30 and 37 years old and presented with a painless mass that was interpreted clinically as a cyst. The tumors were 2.0 and 1.2 cm in greatest diameter. Histologically, they were composed of epithelial cells forming solid nests and gland-like and papillary structures surrounded by spindle-shaped cells. Immunohistochemically, the epithelial cells stained for cytokeratin and the spindle-shaped cells for vimentin. Ultrastructurally, the epithelial cells had prominent intercellular junctions and narrow microvilli and were separated from the spindle-shaped cells by a basal lamina. The spindle-shaped cells were closely apposed with focal intercellular contacts. One tumor recurred locally 3.5 years after excision, but the patient was alive and well 1 year after a re-excision and radiation therapy. The other patient was alive and well 4 years after an excision. These tumors are the first reported examples of synovial sarcoma arising in the vulva.

Original languageEnglish (US)
Pages (from-to)970-974
Number of pages5
JournalModern Pathology
Volume9
Issue number10
StatePublished - Oct 1 1996
Externally publishedYes

Keywords

  • Synovial sarcoma
  • Vulva

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Nielsen, G. P., Shaw, P. A., Rosenberg, A. E., Dickersin, G. R., Young, R. H., & Scully, R. E. (1996). Synovial sarcoma of the vulva: A report of two cases. Modern Pathology, 9(10), 970-974.