Synovial Sarcoma of the Nerve-Clinical and Pathological Features: Case Series and Systematic Review

Stephen Shelby Burks, Ross C. Puffer, Iahn Cajigas, David Valdivia, Andrew E. Rosenberg, Robert J. Spinner, Allan D. Levi

Research output: Contribution to journalReview article

Abstract

BACKGROUND: Synovial sarcoma of the nerve is a rare entity with several cases and case series reported in the literature. Despite an improved understanding of the biology, the clinical course is difficult to predict. OBJECTIVE: To compile a series of patients with synovial sarcoma of the peripheral nerve (SSPN) and assess clinical and pathological factors and their contribution to survival and recurrence. METHODS: Cases from 2 institutions collected in patients undergoing surgical intervention for SSPN. Systematic review including PubMed and Scopus databases were searched for related articles published from 1970 to December 2018. Eligibility criteria: (1) case reports or case series reporting on SSPN, (2) clinical course and/or pathological features of the tumor reported, and (3) articles published in English. RESULTS: From patients treated at our institutions (13) the average follow-up period was 3.2 yr. Tumor recurrence was seen in 4 cases and death in 3. Systematic review of the literature yielded 44 additional cases with an average follow-up period of 3.6 yr. From pooled data, there were 10 recurrences and 7 deaths (20% and 14%, respectively). Adjuvant treatment used in 62.5% of cases. Immunohistochemical markers used in diagnosis varied widely; the most common are the following: Epithelial membrane antigen (EMA), cytokeratin, vimentin, cluster of differentiation (CD34), and transducin-like enhancer of split 1 (TLE1). Statistical analysis illustrated tumor size and use of chemotherapy to be negative predictors of survival. No other factors, clinically or from pathologist review, were correlated with recurrence or survival. CONCLUSION: By combining cases from our institution with historical data and performing statistical analysis we show correlation between tumor size and death.

Original languageEnglish (US)
Pages (from-to)E975-E991
JournalClinical Neurosurgery
Volume85
Issue number6
DOIs
StatePublished - Dec 1 2019

Fingerprint

Synovial Sarcoma
Peripheral Nerves
Recurrence
Survival
Neoplasms
Transducin
Mucin-1
Statistical Data Interpretation
Vimentin
Keratins
PubMed
Databases
Drug Therapy

Keywords

  • Intraneural
  • Peripheral nerve
  • Plexus
  • SSPN
  • Synovial sarcoma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Burks, S. S., Puffer, R. C., Cajigas, I., Valdivia, D., Rosenberg, A. E., Spinner, R. J., & Levi, A. D. (2019). Synovial Sarcoma of the Nerve-Clinical and Pathological Features: Case Series and Systematic Review. Clinical Neurosurgery, 85(6), E975-E991. https://doi.org/10.1093/neuros/nyz321

Synovial Sarcoma of the Nerve-Clinical and Pathological Features : Case Series and Systematic Review. / Burks, Stephen Shelby; Puffer, Ross C.; Cajigas, Iahn; Valdivia, David; Rosenberg, Andrew E.; Spinner, Robert J.; Levi, Allan D.

In: Clinical Neurosurgery, Vol. 85, No. 6, 01.12.2019, p. E975-E991.

Research output: Contribution to journalReview article

Burks, SS, Puffer, RC, Cajigas, I, Valdivia, D, Rosenberg, AE, Spinner, RJ & Levi, AD 2019, 'Synovial Sarcoma of the Nerve-Clinical and Pathological Features: Case Series and Systematic Review', Clinical Neurosurgery, vol. 85, no. 6, pp. E975-E991. https://doi.org/10.1093/neuros/nyz321
Burks SS, Puffer RC, Cajigas I, Valdivia D, Rosenberg AE, Spinner RJ et al. Synovial Sarcoma of the Nerve-Clinical and Pathological Features: Case Series and Systematic Review. Clinical Neurosurgery. 2019 Dec 1;85(6):E975-E991. https://doi.org/10.1093/neuros/nyz321
Burks, Stephen Shelby ; Puffer, Ross C. ; Cajigas, Iahn ; Valdivia, David ; Rosenberg, Andrew E. ; Spinner, Robert J. ; Levi, Allan D. / Synovial Sarcoma of the Nerve-Clinical and Pathological Features : Case Series and Systematic Review. In: Clinical Neurosurgery. 2019 ; Vol. 85, No. 6. pp. E975-E991.
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abstract = "BACKGROUND: Synovial sarcoma of the nerve is a rare entity with several cases and case series reported in the literature. Despite an improved understanding of the biology, the clinical course is difficult to predict. OBJECTIVE: To compile a series of patients with synovial sarcoma of the peripheral nerve (SSPN) and assess clinical and pathological factors and their contribution to survival and recurrence. METHODS: Cases from 2 institutions collected in patients undergoing surgical intervention for SSPN. Systematic review including PubMed and Scopus databases were searched for related articles published from 1970 to December 2018. Eligibility criteria: (1) case reports or case series reporting on SSPN, (2) clinical course and/or pathological features of the tumor reported, and (3) articles published in English. RESULTS: From patients treated at our institutions (13) the average follow-up period was 3.2 yr. Tumor recurrence was seen in 4 cases and death in 3. Systematic review of the literature yielded 44 additional cases with an average follow-up period of 3.6 yr. From pooled data, there were 10 recurrences and 7 deaths (20{\%} and 14{\%}, respectively). Adjuvant treatment used in 62.5{\%} of cases. Immunohistochemical markers used in diagnosis varied widely; the most common are the following: Epithelial membrane antigen (EMA), cytokeratin, vimentin, cluster of differentiation (CD34), and transducin-like enhancer of split 1 (TLE1). Statistical analysis illustrated tumor size and use of chemotherapy to be negative predictors of survival. No other factors, clinically or from pathologist review, were correlated with recurrence or survival. CONCLUSION: By combining cases from our institution with historical data and performing statistical analysis we show correlation between tumor size and death.",
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AU - Puffer, Ross C.

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AU - Valdivia, David

AU - Rosenberg, Andrew E.

AU - Spinner, Robert J.

AU - Levi, Allan D.

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N2 - BACKGROUND: Synovial sarcoma of the nerve is a rare entity with several cases and case series reported in the literature. Despite an improved understanding of the biology, the clinical course is difficult to predict. OBJECTIVE: To compile a series of patients with synovial sarcoma of the peripheral nerve (SSPN) and assess clinical and pathological factors and their contribution to survival and recurrence. METHODS: Cases from 2 institutions collected in patients undergoing surgical intervention for SSPN. Systematic review including PubMed and Scopus databases were searched for related articles published from 1970 to December 2018. Eligibility criteria: (1) case reports or case series reporting on SSPN, (2) clinical course and/or pathological features of the tumor reported, and (3) articles published in English. RESULTS: From patients treated at our institutions (13) the average follow-up period was 3.2 yr. Tumor recurrence was seen in 4 cases and death in 3. Systematic review of the literature yielded 44 additional cases with an average follow-up period of 3.6 yr. From pooled data, there were 10 recurrences and 7 deaths (20% and 14%, respectively). Adjuvant treatment used in 62.5% of cases. Immunohistochemical markers used in diagnosis varied widely; the most common are the following: Epithelial membrane antigen (EMA), cytokeratin, vimentin, cluster of differentiation (CD34), and transducin-like enhancer of split 1 (TLE1). Statistical analysis illustrated tumor size and use of chemotherapy to be negative predictors of survival. No other factors, clinically or from pathologist review, were correlated with recurrence or survival. CONCLUSION: By combining cases from our institution with historical data and performing statistical analysis we show correlation between tumor size and death.

AB - BACKGROUND: Synovial sarcoma of the nerve is a rare entity with several cases and case series reported in the literature. Despite an improved understanding of the biology, the clinical course is difficult to predict. OBJECTIVE: To compile a series of patients with synovial sarcoma of the peripheral nerve (SSPN) and assess clinical and pathological factors and their contribution to survival and recurrence. METHODS: Cases from 2 institutions collected in patients undergoing surgical intervention for SSPN. Systematic review including PubMed and Scopus databases were searched for related articles published from 1970 to December 2018. Eligibility criteria: (1) case reports or case series reporting on SSPN, (2) clinical course and/or pathological features of the tumor reported, and (3) articles published in English. RESULTS: From patients treated at our institutions (13) the average follow-up period was 3.2 yr. Tumor recurrence was seen in 4 cases and death in 3. Systematic review of the literature yielded 44 additional cases with an average follow-up period of 3.6 yr. From pooled data, there were 10 recurrences and 7 deaths (20% and 14%, respectively). Adjuvant treatment used in 62.5% of cases. Immunohistochemical markers used in diagnosis varied widely; the most common are the following: Epithelial membrane antigen (EMA), cytokeratin, vimentin, cluster of differentiation (CD34), and transducin-like enhancer of split 1 (TLE1). Statistical analysis illustrated tumor size and use of chemotherapy to be negative predictors of survival. No other factors, clinically or from pathologist review, were correlated with recurrence or survival. CONCLUSION: By combining cases from our institution with historical data and performing statistical analysis we show correlation between tumor size and death.

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