Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood

L. Hu, Y. Cai, J. B. Greer, Helena M Solo-Gabriele, Lynne A Fieber

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The neurotoxicity of Arsenic (As) associated with Chrome Copper Arsenate (CCA)-treated wood when accompanied by chromium and copper was studied. Cells of the human neuroblastoma line SK-N-SH were cultured with CCA-treated wood leachates or with solutions containing pentavalent arsenic [As(V)], divalent copper [Cu(II)], trivalent chromium [Cr(III)] alone or in different combinations of the three elements. The toxicity was evaluated using variations in cell replication compared to controls after 96 h exposure. Exposure of SK-N-SH to CCA-treated wood leachates resulted in inhibition of cell proliferation and cell death depending on the exposure concentration, with the EC50 for cell death for As(V) in wood leachates (10.7 μM)) at lower values than for As alone (21.1 μM). As(V) toxicity was enhanced with the presence of Cu(II), while decreased with Cr(III). Dissolved Organic Matter (DOM) reduced the adsorption of As(V), but enhanced the uptake of Cr(III) into the test cells.

Original languageEnglish
Title of host publicationUnderstanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment
Pages199-200
Number of pages2
StatePublished - Aug 16 2012
Event4th International Congress on Arsenic in the Environment, As 2012 - Cairns, QLD, Australia
Duration: Jul 22 2012Jul 27 2012

Other

Other4th International Congress on Arsenic in the Environment, As 2012
CountryAustralia
CityCairns, QLD
Period7/22/127/27/12

Fingerprint

Poisons
Arsenic
Chromium
arsenate
chromium
Copper
arsenic
Wood
copper
leachate
Cell death
Toxicity
toxicity
Cell proliferation
arsenic acid
toxic effect
dissolved organic matter
Biological materials
Cells
adsorption

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

Cite this

Hu, L., Cai, Y., Greer, J. B., Solo-Gabriele, H. M., & Fieber, L. A. (2012). Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood. In Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment (pp. 199-200)

Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood. / Hu, L.; Cai, Y.; Greer, J. B.; Solo-Gabriele, Helena M; Fieber, Lynne A.

Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment. 2012. p. 199-200.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hu, L, Cai, Y, Greer, JB, Solo-Gabriele, HM & Fieber, LA 2012, Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood. in Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment. pp. 199-200, 4th International Congress on Arsenic in the Environment, As 2012, Cairns, QLD, Australia, 7/22/12.
Hu L, Cai Y, Greer JB, Solo-Gabriele HM, Fieber LA. Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood. In Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment. 2012. p. 199-200
Hu, L. ; Cai, Y. ; Greer, J. B. ; Solo-Gabriele, Helena M ; Fieber, Lynne A. / Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood. Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment. 2012. pp. 199-200
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