Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood

L. Hu, Y. Cai, J. B. Greer, H. Solo-Gabriele, L. A. Fieber

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The neurotoxicity of Arsenic (As) associated with Chrome Copper Arsenate (CCA)-treated wood when accompanied by chromium and copper was studied. Cells of the human neuroblastoma line SK-N-SH were cultured with CCA-treated wood leachates or with solutions containing pentavalent arsenic [As(V)], divalent copper [Cu(II)], trivalent chromium [Cr(III)] alone or in different combinations of the three elements. The toxicity was evaluated using variations in cell replication compared to controls after 96 h exposure. Exposure of SK-N-SH to CCA-treated wood leachates resulted in inhibition of cell proliferation and cell death depending on the exposure concentration, with the EC50 for cell death for As(V) in wood leachates (10.7 μM)) at lower values than for As alone (21.1 μM). As(V) toxicity was enhanced with the presence of Cu(II), while decreased with Cr(III). Dissolved Organic Matter (DOM) reduced the adsorption of As(V), but enhanced the uptake of Cr(III) into the test cells.

Original languageEnglish (US)
Title of host publicationUnderstanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress
Subtitle of host publicationArsenic in the Environment
PublisherTaylor and Francis - Balkema
Pages199-200
Number of pages2
ISBN (Print)9780415637633
DOIs
StatePublished - Jan 1 2012
Event4th International Congress on Arsenic in the Environment, As 2012 - Cairns, QLD, Australia
Duration: Jul 22 2012Jul 27 2012

Publication series

NameUnderstanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment

Other

Other4th International Congress on Arsenic in the Environment, As 2012
CountryAustralia
CityCairns, QLD
Period7/22/127/27/12

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

Fingerprint Dive into the research topics of 'Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood'. Together they form a unique fingerprint.

  • Cite this

    Hu, L., Cai, Y., Greer, J. B., Solo-Gabriele, H., & Fieber, L. A. (2012). Synergistic toxic effects among arsenic, chromium and copper associated with chrome copper arsenate-treated wood. In Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment (pp. 199-200). (Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment). Taylor and Francis - Balkema. https://doi.org/10.1201/b12522-78