TY - JOUR
T1 - Syndemics and salivary inflammation in people living with HIV/AIDS
AU - Rogers, Brooke G.
AU - Glynn, Tiffany R.
AU - Bainter, Sierra A.
AU - McCauley, Thomas
AU - Antoni, Michael H.
AU - Safren, Steven A.
N1 - Funding Information:
Research reported in this paper was supported by the National Institute of Mental Health of the National Institutes of Health under Award Number F31MH113481 (Rogers) and some author time came from 9K24DA040489 (Safren). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This study was also supported by the Department of Psychology at the University of Miami.
Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Objective: People living with HIV/AIDS (PLWHA) are disproportionally exposed to a host of structural, community, and individual-level physical and psychosocial stressors also termed ‘syndemic conditions.’ The current study aimed to examine the association between experiencing syndemic conditions and physiological stress response and be associated with bodily inflammation, including Interlekin-6 (IL-6) and C-reactive protein (CRP) in PLWHA. Design: Participants (N = 103) were recruited from a public HIV clinic. They provided saliva samples of IL-6 and CRP and completed psychosocial measures. Main outcome measures: Levels of circulating salivary IL-6 and CRP. Results: When predictors (birth country, recent housing instability, and incarceration history) were simultaneously entered into a regression model, only incarceration history was negatively associated with IL-6 [b = −.27, t(98) = −3.11, p =.002]. For CRP, the resulting regression model was not significant, [F(3, 98) = 2.23, p =.090]. Conclusion: Although we had expected higher levels of syndemics to be associated with higher levels of circulating inflammation, in our sample, length of incarceration was associated with lower levels of circulating IL-6. Findings are therefore suggestive of a stress response disruption resulting in a negative feedback loop as the long-term impact of chronic stress on inflammation.
AB - Objective: People living with HIV/AIDS (PLWHA) are disproportionally exposed to a host of structural, community, and individual-level physical and psychosocial stressors also termed ‘syndemic conditions.’ The current study aimed to examine the association between experiencing syndemic conditions and physiological stress response and be associated with bodily inflammation, including Interlekin-6 (IL-6) and C-reactive protein (CRP) in PLWHA. Design: Participants (N = 103) were recruited from a public HIV clinic. They provided saliva samples of IL-6 and CRP and completed psychosocial measures. Main outcome measures: Levels of circulating salivary IL-6 and CRP. Results: When predictors (birth country, recent housing instability, and incarceration history) were simultaneously entered into a regression model, only incarceration history was negatively associated with IL-6 [b = −.27, t(98) = −3.11, p =.002]. For CRP, the resulting regression model was not significant, [F(3, 98) = 2.23, p =.090]. Conclusion: Although we had expected higher levels of syndemics to be associated with higher levels of circulating inflammation, in our sample, length of incarceration was associated with lower levels of circulating IL-6. Findings are therefore suggestive of a stress response disruption resulting in a negative feedback loop as the long-term impact of chronic stress on inflammation.
KW - HIV
KW - cytokines
KW - inflammation
KW - syndemic
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U2 - 10.1080/08870446.2020.1763995
DO - 10.1080/08870446.2020.1763995
M3 - Article
C2 - 32400209
AN - SCOPUS:85084804090
VL - 36
SP - 496
EP - 510
JO - Psychology and Health
JF - Psychology and Health
SN - 0887-0446
IS - 4
ER -