Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand

Jeremy D. Coplan, Margaret Altemus, Sanjay J. Mathew, Eric L.P. Smith, Bruce Scharf, Paul M. Coplan, John G. Kral, Jack M. Gorman, Michael J. Owens, Charles B. Nemeroff, Leonard A. Rosenblum

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Abstract

Background: The study of environment-gene interactions during neurodevelopment may facilitate our understanding of the origins of psychiatric disorders. Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident. Objectives: In the current study, we wished to examine if central corticotropin-releasing factor (CRF) would provide a plausible biological vehicle for synchronized increases in mothers and their infant. Methods: Twenty-four mother-infant bonnet macaques (Macaca radiata) dyads, of known age and weight served as subjects. The subjects were group-housed in four pens of 5-7 dyads each, stabilized for several weeks prior to the study period. Although adequate food was always available, mothers faced uncertainty of food availability for 16 weeks within the first year of infant life, through a procedure dubbed "variable foraging demand" (VFD). Pre- and post-VFD cerebrospinal fluid (CSF) samples were obtained simultaneously on mothers and infants. Results: Maternal CSF CRF concentrations exhibited a significant mean elevation of 26% from pre-VFD to post-VFD; there was no effect of number of days postpartum on maternal pre-VFD CSF CRF levels. There was a significant mean increase (45%) in infant CSF CRF concentrations over the 16-week period of the VFD paradigm. No infant sex differences were evident. Post-VFD minus pre-VFD differences in infant CSF CRF concentrations were positively correlated (r=.52; N=16; P=.0384) with the magnitude of maternal CRF response to VFD, providing evidence of synchronized CSF CRF expression by the dyad. Conclusion: This parallel response within the dyad suggests, as one testable hypothesis, that maternal responsivity to the stress of the VFD condition is "communicated" between mother and infant via a CRF-mediated mechanism. The VFD stressor produces a parallel activation of the central CRF system in both mothers and their infants.

Original languageEnglish (US)
Pages (from-to)530-536
Number of pages7
JournalCNS spectrums
Volume10
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Coplan, J. D., Altemus, M., Mathew, S. J., Smith, E. L. P., Scharf, B., Coplan, P. M., Kral, J. G., Gorman, J. M., Owens, M. J., Nemeroff, C. B., & Rosenblum, L. A. (2005). Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand. CNS spectrums, 10(7), 530-536. https://doi.org/10.1017/S109285290001018X