Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand

Jeremy D. Coplan, Margaret Altemus, Sanjay J. Mathew, Eric L P Smith, Bruce Scharf, Paul M. Coplan, John G. Kral, Jack M. Gorman, Michael J. Owens, Charles Nemeroff, Leonard A. Rosenblum

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: The study of environment-gene interactions during neurodevelopment may facilitate our understanding of the origins of psychiatric disorders. Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident. Objectives: In the current study, we wished to examine if central corticotropin-releasing factor (CRF) would provide a plausible biological vehicle for synchronized increases in mothers and their infant. Methods: Twenty-four mother-infant bonnet macaques (Macaca radiata) dyads, of known age and weight served as subjects. The subjects were group-housed in four pens of 5-7 dyads each, stabilized for several weeks prior to the study period. Although adequate food was always available, mothers faced uncertainty of food availability for 16 weeks within the first year of infant life, through a procedure dubbed "variable foraging demand" (VFD). Pre- and post-VFD cerebrospinal fluid (CSF) samples were obtained simultaneously on mothers and infants. Results: Maternal CSF CRF concentrations exhibited a significant mean elevation of 26% from pre-VFD to post-VFD; there was no effect of number of days postpartum on maternal pre-VFD CSF CRF levels. There was a significant mean increase (45%) in infant CSF CRF concentrations over the 16-week period of the VFD paradigm. No infant sex differences were evident. Post-VFD minus pre-VFD differences in infant CSF CRF concentrations were positively correlated (r=.52; N=16; P=.0384) with the magnitude of maternal CRF response to VFD, providing evidence of synchronized CSF CRF expression by the dyad. Conclusion: This parallel response within the dyad suggests, as one testable hypothesis, that maternal responsivity to the stress of the VFD condition is "communicated" between mother and infant via a CRF-mediated mechanism. The VFD stressor produces a parallel activation of the central CRF system in both mothers and their infants.

Original languageEnglish
Pages (from-to)530-536
Number of pages7
JournalCNS Spectrums
Volume10
Issue number7
StatePublished - Jul 1 2005
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Primates
Cerebrospinal Fluid
Mothers
Macaca radiata
Food
Gene-Environment Interaction
Neurobiology
Psychopathology
Sex Characteristics
Postpartum Period
Uncertainty
Psychiatry
Weights and Measures

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Coplan, J. D., Altemus, M., Mathew, S. J., Smith, E. L. P., Scharf, B., Coplan, P. M., ... Rosenblum, L. A. (2005). Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand. CNS Spectrums, 10(7), 530-536.

Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand. / Coplan, Jeremy D.; Altemus, Margaret; Mathew, Sanjay J.; Smith, Eric L P; Scharf, Bruce; Coplan, Paul M.; Kral, John G.; Gorman, Jack M.; Owens, Michael J.; Nemeroff, Charles; Rosenblum, Leonard A.

In: CNS Spectrums, Vol. 10, No. 7, 01.07.2005, p. 530-536.

Research output: Contribution to journalArticle

Coplan, JD, Altemus, M, Mathew, SJ, Smith, ELP, Scharf, B, Coplan, PM, Kral, JG, Gorman, JM, Owens, MJ, Nemeroff, C & Rosenblum, LA 2005, 'Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand', CNS Spectrums, vol. 10, no. 7, pp. 530-536.
Coplan JD, Altemus M, Mathew SJ, Smith ELP, Scharf B, Coplan PM et al. Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand. CNS Spectrums. 2005 Jul 1;10(7):530-536.
Coplan, Jeremy D. ; Altemus, Margaret ; Mathew, Sanjay J. ; Smith, Eric L P ; Scharf, Bruce ; Coplan, Paul M. ; Kral, John G. ; Gorman, Jack M. ; Owens, Michael J. ; Nemeroff, Charles ; Rosenblum, Leonard A. / Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand. In: CNS Spectrums. 2005 ; Vol. 10, No. 7. pp. 530-536.
@article{871a520e4ad34398a5c0a79efedccae8,
title = "Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand",
abstract = "Background: The study of environment-gene interactions during neurodevelopment may facilitate our understanding of the origins of psychiatric disorders. Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident. Objectives: In the current study, we wished to examine if central corticotropin-releasing factor (CRF) would provide a plausible biological vehicle for synchronized increases in mothers and their infant. Methods: Twenty-four mother-infant bonnet macaques (Macaca radiata) dyads, of known age and weight served as subjects. The subjects were group-housed in four pens of 5-7 dyads each, stabilized for several weeks prior to the study period. Although adequate food was always available, mothers faced uncertainty of food availability for 16 weeks within the first year of infant life, through a procedure dubbed {"}variable foraging demand{"} (VFD). Pre- and post-VFD cerebrospinal fluid (CSF) samples were obtained simultaneously on mothers and infants. Results: Maternal CSF CRF concentrations exhibited a significant mean elevation of 26{\%} from pre-VFD to post-VFD; there was no effect of number of days postpartum on maternal pre-VFD CSF CRF levels. There was a significant mean increase (45{\%}) in infant CSF CRF concentrations over the 16-week period of the VFD paradigm. No infant sex differences were evident. Post-VFD minus pre-VFD differences in infant CSF CRF concentrations were positively correlated (r=.52; N=16; P=.0384) with the magnitude of maternal CRF response to VFD, providing evidence of synchronized CSF CRF expression by the dyad. Conclusion: This parallel response within the dyad suggests, as one testable hypothesis, that maternal responsivity to the stress of the VFD condition is {"}communicated{"} between mother and infant via a CRF-mediated mechanism. The VFD stressor produces a parallel activation of the central CRF system in both mothers and their infants.",
author = "Coplan, {Jeremy D.} and Margaret Altemus and Mathew, {Sanjay J.} and Smith, {Eric L P} and Bruce Scharf and Coplan, {Paul M.} and Kral, {John G.} and Gorman, {Jack M.} and Owens, {Michael J.} and Charles Nemeroff and Rosenblum, {Leonard A.}",
year = "2005",
month = "7",
day = "1",
language = "English",
volume = "10",
pages = "530--536",
journal = "CNS Spectrums",
issn = "1092-8529",
publisher = "MBL Communications",
number = "7",

}

TY - JOUR

T1 - Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand

AU - Coplan, Jeremy D.

AU - Altemus, Margaret

AU - Mathew, Sanjay J.

AU - Smith, Eric L P

AU - Scharf, Bruce

AU - Coplan, Paul M.

AU - Kral, John G.

AU - Gorman, Jack M.

AU - Owens, Michael J.

AU - Nemeroff, Charles

AU - Rosenblum, Leonard A.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Background: The study of environment-gene interactions during neurodevelopment may facilitate our understanding of the origins of psychiatric disorders. Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident. Objectives: In the current study, we wished to examine if central corticotropin-releasing factor (CRF) would provide a plausible biological vehicle for synchronized increases in mothers and their infant. Methods: Twenty-four mother-infant bonnet macaques (Macaca radiata) dyads, of known age and weight served as subjects. The subjects were group-housed in four pens of 5-7 dyads each, stabilized for several weeks prior to the study period. Although adequate food was always available, mothers faced uncertainty of food availability for 16 weeks within the first year of infant life, through a procedure dubbed "variable foraging demand" (VFD). Pre- and post-VFD cerebrospinal fluid (CSF) samples were obtained simultaneously on mothers and infants. Results: Maternal CSF CRF concentrations exhibited a significant mean elevation of 26% from pre-VFD to post-VFD; there was no effect of number of days postpartum on maternal pre-VFD CSF CRF levels. There was a significant mean increase (45%) in infant CSF CRF concentrations over the 16-week period of the VFD paradigm. No infant sex differences were evident. Post-VFD minus pre-VFD differences in infant CSF CRF concentrations were positively correlated (r=.52; N=16; P=.0384) with the magnitude of maternal CRF response to VFD, providing evidence of synchronized CSF CRF expression by the dyad. Conclusion: This parallel response within the dyad suggests, as one testable hypothesis, that maternal responsivity to the stress of the VFD condition is "communicated" between mother and infant via a CRF-mediated mechanism. The VFD stressor produces a parallel activation of the central CRF system in both mothers and their infants.

AB - Background: The study of environment-gene interactions during neurodevelopment may facilitate our understanding of the origins of psychiatric disorders. Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident. Objectives: In the current study, we wished to examine if central corticotropin-releasing factor (CRF) would provide a plausible biological vehicle for synchronized increases in mothers and their infant. Methods: Twenty-four mother-infant bonnet macaques (Macaca radiata) dyads, of known age and weight served as subjects. The subjects were group-housed in four pens of 5-7 dyads each, stabilized for several weeks prior to the study period. Although adequate food was always available, mothers faced uncertainty of food availability for 16 weeks within the first year of infant life, through a procedure dubbed "variable foraging demand" (VFD). Pre- and post-VFD cerebrospinal fluid (CSF) samples were obtained simultaneously on mothers and infants. Results: Maternal CSF CRF concentrations exhibited a significant mean elevation of 26% from pre-VFD to post-VFD; there was no effect of number of days postpartum on maternal pre-VFD CSF CRF levels. There was a significant mean increase (45%) in infant CSF CRF concentrations over the 16-week period of the VFD paradigm. No infant sex differences were evident. Post-VFD minus pre-VFD differences in infant CSF CRF concentrations were positively correlated (r=.52; N=16; P=.0384) with the magnitude of maternal CRF response to VFD, providing evidence of synchronized CSF CRF expression by the dyad. Conclusion: This parallel response within the dyad suggests, as one testable hypothesis, that maternal responsivity to the stress of the VFD condition is "communicated" between mother and infant via a CRF-mediated mechanism. The VFD stressor produces a parallel activation of the central CRF system in both mothers and their infants.

UR - http://www.scopus.com/inward/record.url?scp=22844449709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22844449709&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 530

EP - 536

JO - CNS Spectrums

JF - CNS Spectrums

SN - 1092-8529

IS - 7

ER -