Synapse regeneration, axon sprouting and degeneration in the central nervous system of the leech

SYNOPSIS. Detailed know ledge of the projections and synaptic connections of identifiable neurons in the leech has permitted a similarly detailed study of the sprouting, regeneration, and degeneration of axons We have learned that certain cellular components, such as synaptic targets and gha, may play only a limned role in synapse regeneration and in axon degeneration Yet contact with the synaptic target may inhibit sprouting and availability of targets may promote it Overall, results in the leech support the idea that degeneration as well as regeneration share fundamental mechanisms with other invertebrates and the vertebrates including mammals.