TY - JOUR
T1 - Synapse regeneration, axon sprouting and degeneration in the central nervous system of the leech
AU - Muller, Kenneth J.
N1 - Funding Information:
I thank my colleagues for permission to cite unpublished work. Supported by USPHS Grant RO1 NS20607.
PY - 1988
Y1 - 1988
N2 - SYNOPSIS. Detailed know ledge of the projections and synaptic connections of identifiable neurons in the leech has permitted a similarly detailed study of the sprouting, regeneration, and degeneration of axons We have learned that certain cellular components, such as synaptic targets and gha, may play only a limned role in synapse regeneration and in axon degeneration Yet contact with the synaptic target may inhibit sprouting and availability of targets may promote it Overall, results in the leech support the idea that degeneration as well as regeneration share fundamental mechanisms with other invertebrates and the vertebrates including mammals.
AB - SYNOPSIS. Detailed know ledge of the projections and synaptic connections of identifiable neurons in the leech has permitted a similarly detailed study of the sprouting, regeneration, and degeneration of axons We have learned that certain cellular components, such as synaptic targets and gha, may play only a limned role in synapse regeneration and in axon degeneration Yet contact with the synaptic target may inhibit sprouting and availability of targets may promote it Overall, results in the leech support the idea that degeneration as well as regeneration share fundamental mechanisms with other invertebrates and the vertebrates including mammals.
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U2 - 10.1093/icb/28.4.1091
DO - 10.1093/icb/28.4.1091
M3 - Article
AN - SCOPUS:0008266957
VL - 28
SP - 1091
EP - 1097
JO - Integrative and Comparative Biology
JF - Integrative and Comparative Biology
SN - 1540-7063
IS - 4
ER -