Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma

Jesse A. Green, Rafael Amaro, Jamie S. Barkin

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


A population-based, case-control study to investigate the possible association between gastroesophageal reflux (GER) and adenocarcinoma of the esophagus and gastric cardia was performed. It demonstrated an odds ratio of 7.7 for esophageal adenocarcinoma in patients with GER symptoms. The frequency, severity, and duration of symptoms correlated with an increased risk of esophageal adenocarcinoma. A weaker association was noted for GER and adenocarcinoma of the gastric cardia. No association surfaced between GER and squamous cell carcinoma of the esophagus.

Original languageEnglish (US)
Pages (from-to)2367-2368
Number of pages2
JournalDigestive Diseases and Sciences
Issue number12
StatePublished - 2000


  • Adenocarcinoma
  • Gastroesophageal reflux

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma'. Together they form a unique fingerprint.

Cite this