Symposium: Molecular mechanisms of protective effects of vitamin E in atherosclerosis: Nonantioxidant functions of α-tocopherol in smooth muscle cells

A. Azzi, I. Breyer, M. Feher, R. Ricciarelli, A. Stocker, S. Zimmer, J. M. Zingg

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Most tocopherols and tocotrienols, with the exception of α-tocopherol, are not retained by humans. This suggests that α-tocopherol is recognized uniquely; therefore, it may exert an exclusive function, α-Tocopherol possesses distinct properties that are independent of its prooxidant, antioxidant or radical-scavenging ability. α-Tocopherol specifically inhibits protein kinase C, the growth of certain cells and the transcription of the CD36 and collagenase genes. Activation events have also been seen on the protein phosphatase 2A (PP2A) and on the expression of other genes (α-tropomyosin and connective tissue growth factor). Neither β-tocopherol nor probucol possessed the same specialty functions as α-tocopherol. Recently, we isolated a new ubiquitous cytosolic α-tocopherol binding protein (TAP). Its motifs suggest that it is a member of the hydrophobic ligand-binding protein family (CRAL-TRIO). TAP may also be involved in the regulation of cellular α-tocopherol concentration and α-tocopherol-mediated signaling.

Original languageEnglish (US)
Pages (from-to)378S-381S
JournalJournal of Nutrition
Volume131
Issue number2
StatePublished - 2001
Externally publishedYes

Keywords

  • α-tocopherol binding protein
  • Cell signaling
  • Tocopherols
  • Tocotrienols

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint

Dive into the research topics of 'Symposium: Molecular mechanisms of protective effects of vitamin E in atherosclerosis: Nonantioxidant functions of α-tocopherol in smooth muscle cells'. Together they form a unique fingerprint.

Cite this