Sympathetic postganglionic unmyelinated axons in the rat peripheral nervous system

David Chad, Walter G. Bradley, Chaudri Rasool, Paul Good, Seymour Reichlin, Justin Zivin

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We determined the contribution made to the unmyelinated axon population of the rat peripheral nervous system by sympathetic paravertebral ganglion cells. Sympathectomy, achieved by administration of guanethidine to neonatal rats, led to atrophy of the sympathetic paravertebral ganglion chain, a 95% decrease in peripheral nerve norepinephrine, and loss of 20 to 26% of the unmyelinated axons in a cutaneous nerve (sural), a muscular nerve (nerve to soleus), and a mixed nerve (sciatic). These data indicate that up to a quarter of the total population of peripheral nerve unmyelinated axons are sympathetic ganglia-derived.

Original languageEnglish (US)
Pages (from-to)841-847
Number of pages7
JournalNeurology
Volume33
Issue number7
DOIs
StatePublished - Jul 1983
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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