Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms

Yanping Huang, Qinqin Zhang, Mariana R. Thorell, Lin An, Mary K. Durbin, Michal Laron, Utkarsh Sharma, Giovanni Gregori, Philip J Rosenfeld, Ruikang K. Wang

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. MATERIALS AND METHODS: Volumetric data sets were acquired using a 1-μm SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan an approximately 3 x 3-mm area in the central macular region of the retina within approximately 4.5 seconds. An intensity differentiation-based OMAG algorithm was used to extract three-dimensional retinal functional microvasculature information. RESULTS: Intensity signal differentiation generated capillary-level resolution en face OMAG images of the retina. The parafoveal capillaries were clearly visible, thereby allowing visualization of the foveal avascular zone in healthy subjects. CONCLUSION: The capability of OMAG to produce retinal vascular images was demonstrated using the 1-μm SS-OCT prototype. This technique has potential clinical value for studying retinal vasculature abnormalities.

Original languageEnglish
Pages (from-to)382-389
Number of pages8
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume45
Issue number5
DOIs
StatePublished - Jan 1 2014

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Optical Coherence Tomography
Angiography
Retina
Retinal Vessels
Microvessels
Healthy Volunteers

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

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Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms. / Huang, Yanping; Zhang, Qinqin; Thorell, Mariana R.; An, Lin; Durbin, Mary K.; Laron, Michal; Sharma, Utkarsh; Gregori, Giovanni; Rosenfeld, Philip J; Wang, Ruikang K.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 45, No. 5, 01.01.2014, p. 382-389.

Research output: Contribution to journalArticle

Huang, Yanping ; Zhang, Qinqin ; Thorell, Mariana R. ; An, Lin ; Durbin, Mary K. ; Laron, Michal ; Sharma, Utkarsh ; Gregori, Giovanni ; Rosenfeld, Philip J ; Wang, Ruikang K. / Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms. In: Ophthalmic Surgery Lasers and Imaging Retina. 2014 ; Vol. 45, No. 5. pp. 382-389.
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