Abstract
BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. MATERIALS AND METHODS: Volumetric data sets were acquired using a 1-μm SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan an approximately 3 x 3-mm area in the central macular region of the retina within approximately 4.5 seconds. An intensity differentiation-based OMAG algorithm was used to extract three-dimensional retinal functional microvasculature information. RESULTS: Intensity signal differentiation generated capillary-level resolution en face OMAG images of the retina. The parafoveal capillaries were clearly visible, thereby allowing visualization of the foveal avascular zone in healthy subjects. CONCLUSION: The capability of OMAG to produce retinal vascular images was demonstrated using the 1-μm SS-OCT prototype. This technique has potential clinical value for studying retinal vasculature abnormalities.
| Original language | English |
|---|---|
| Pages (from-to) | 382-389 |
| Number of pages | 8 |
| Journal | Ophthalmic Surgery Lasers and Imaging Retina |
| Volume | 45 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2014 |
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ASJC Scopus subject areas
- Ophthalmology
- Surgery
Cite this
Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms. / Huang, Yanping; Zhang, Qinqin; Thorell, Mariana R.; An, Lin; Durbin, Mary K.; Laron, Michal; Sharma, Utkarsh; Gregori, Giovanni; Rosenfeld, Philip J; Wang, Ruikang K.
In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 45, No. 5, 01.01.2014, p. 382-389.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms
AU - Huang, Yanping
AU - Zhang, Qinqin
AU - Thorell, Mariana R.
AU - An, Lin
AU - Durbin, Mary K.
AU - Laron, Michal
AU - Sharma, Utkarsh
AU - Gregori, Giovanni
AU - Rosenfeld, Philip J
AU - Wang, Ruikang K.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. MATERIALS AND METHODS: Volumetric data sets were acquired using a 1-μm SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan an approximately 3 x 3-mm area in the central macular region of the retina within approximately 4.5 seconds. An intensity differentiation-based OMAG algorithm was used to extract three-dimensional retinal functional microvasculature information. RESULTS: Intensity signal differentiation generated capillary-level resolution en face OMAG images of the retina. The parafoveal capillaries were clearly visible, thereby allowing visualization of the foveal avascular zone in healthy subjects. CONCLUSION: The capability of OMAG to produce retinal vascular images was demonstrated using the 1-μm SS-OCT prototype. This technique has potential clinical value for studying retinal vasculature abnormalities.
AB - BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. MATERIALS AND METHODS: Volumetric data sets were acquired using a 1-μm SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan an approximately 3 x 3-mm area in the central macular region of the retina within approximately 4.5 seconds. An intensity differentiation-based OMAG algorithm was used to extract three-dimensional retinal functional microvasculature information. RESULTS: Intensity signal differentiation generated capillary-level resolution en face OMAG images of the retina. The parafoveal capillaries were clearly visible, thereby allowing visualization of the foveal avascular zone in healthy subjects. CONCLUSION: The capability of OMAG to produce retinal vascular images was demonstrated using the 1-μm SS-OCT prototype. This technique has potential clinical value for studying retinal vasculature abnormalities.
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UR - http://www.scopus.com/inward/citedby.url?scp=84911429405&partnerID=8YFLogxK
U2 - 10.3928/23258160-20140909-08
DO - 10.3928/23258160-20140909-08
M3 - Article
C2 - 25230403
AN - SCOPUS:84911429405
VL - 45
SP - 382
EP - 389
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
SN - 2325-8160
IS - 5
ER -