Swept-source OCT angiography of macular telangiectasia type 2

Mariana R. Thorell, Qinqin Zhang, Yanping Huang, Lin An, Mary K. Durbin, Michal Laron, Utkarsh Sharma, Paul F. Stetson, Giovanni Gregori, Ruikang K. Wang, Philip J Rosenfeld

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG). PATIENTS AND METHODS: Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm x 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en face images, and qualitative information was compared to fluorescein angiography (FA) images. RESULTS: OMAG detected abnormal microvasculature in all MacTel2 eyes, predominantly in the middle retinal layers with neovascularization in the outer retina. These vessels correlated well with the FA alterations. The abnormal temporal, juxtafoveal microvasculature in MacTel2 became apparent as the disease progressed and in later stages tended to extend circumferentially, with anastomotic vessels temporally. CONCLUSION: OMAG provided detailed, depth-resolved information about the perifoveal macular microvasculature in MacTel2. In most cases, images were better using OMAG than FA. The OMAG images demonstrated that most of the leakage seen on FA appeared to arise from the abnormal perifoveal microvasculature in the middle retinal layer.

Original languageEnglish
Pages (from-to)369-380
Number of pages12
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume45
Issue number5
DOIs
StatePublished - Jan 1 2014

Fingerprint

Telangiectasis
Optical Coherence Tomography
Microvessels
Fluorescein Angiography
Angiography
Retina
Observational Studies
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Swept-source OCT angiography of macular telangiectasia type 2. / Thorell, Mariana R.; Zhang, Qinqin; Huang, Yanping; An, Lin; Durbin, Mary K.; Laron, Michal; Sharma, Utkarsh; Stetson, Paul F.; Gregori, Giovanni; Wang, Ruikang K.; Rosenfeld, Philip J.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 45, No. 5, 01.01.2014, p. 369-380.

Research output: Contribution to journalArticle

Thorell, MR, Zhang, Q, Huang, Y, An, L, Durbin, MK, Laron, M, Sharma, U, Stetson, PF, Gregori, G, Wang, RK & Rosenfeld, PJ 2014, 'Swept-source OCT angiography of macular telangiectasia type 2', Ophthalmic Surgery Lasers and Imaging Retina, vol. 45, no. 5, pp. 369-380. https://doi.org/10.3928/23258160-20140909-06
Thorell, Mariana R. ; Zhang, Qinqin ; Huang, Yanping ; An, Lin ; Durbin, Mary K. ; Laron, Michal ; Sharma, Utkarsh ; Stetson, Paul F. ; Gregori, Giovanni ; Wang, Ruikang K. ; Rosenfeld, Philip J. / Swept-source OCT angiography of macular telangiectasia type 2. In: Ophthalmic Surgery Lasers and Imaging Retina. 2014 ; Vol. 45, No. 5. pp. 369-380.
@article{c5d69776baca4d77bc8ee8c884221456,
title = "Swept-source OCT angiography of macular telangiectasia type 2",
abstract = "BACKGROUND AND OBJECTIVE: To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG). PATIENTS AND METHODS: Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm x 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en face images, and qualitative information was compared to fluorescein angiography (FA) images. RESULTS: OMAG detected abnormal microvasculature in all MacTel2 eyes, predominantly in the middle retinal layers with neovascularization in the outer retina. These vessels correlated well with the FA alterations. The abnormal temporal, juxtafoveal microvasculature in MacTel2 became apparent as the disease progressed and in later stages tended to extend circumferentially, with anastomotic vessels temporally. CONCLUSION: OMAG provided detailed, depth-resolved information about the perifoveal macular microvasculature in MacTel2. In most cases, images were better using OMAG than FA. The OMAG images demonstrated that most of the leakage seen on FA appeared to arise from the abnormal perifoveal microvasculature in the middle retinal layer.",
author = "Thorell, {Mariana R.} and Qinqin Zhang and Yanping Huang and Lin An and Durbin, {Mary K.} and Michal Laron and Utkarsh Sharma and Stetson, {Paul F.} and Giovanni Gregori and Wang, {Ruikang K.} and Rosenfeld, {Philip J}",
year = "2014",
month = "1",
day = "1",
doi = "10.3928/23258160-20140909-06",
language = "English",
volume = "45",
pages = "369--380",
journal = "Ophthalmic Surgery Lasers and Imaging Retina",
issn = "2325-8160",
publisher = "Slack Incorporated",
number = "5",

}

TY - JOUR

T1 - Swept-source OCT angiography of macular telangiectasia type 2

AU - Thorell, Mariana R.

AU - Zhang, Qinqin

AU - Huang, Yanping

AU - An, Lin

AU - Durbin, Mary K.

AU - Laron, Michal

AU - Sharma, Utkarsh

AU - Stetson, Paul F.

AU - Gregori, Giovanni

AU - Wang, Ruikang K.

AU - Rosenfeld, Philip J

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BACKGROUND AND OBJECTIVE: To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG). PATIENTS AND METHODS: Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm x 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en face images, and qualitative information was compared to fluorescein angiography (FA) images. RESULTS: OMAG detected abnormal microvasculature in all MacTel2 eyes, predominantly in the middle retinal layers with neovascularization in the outer retina. These vessels correlated well with the FA alterations. The abnormal temporal, juxtafoveal microvasculature in MacTel2 became apparent as the disease progressed and in later stages tended to extend circumferentially, with anastomotic vessels temporally. CONCLUSION: OMAG provided detailed, depth-resolved information about the perifoveal macular microvasculature in MacTel2. In most cases, images were better using OMAG than FA. The OMAG images demonstrated that most of the leakage seen on FA appeared to arise from the abnormal perifoveal microvasculature in the middle retinal layer.

AB - BACKGROUND AND OBJECTIVE: To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG). PATIENTS AND METHODS: Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm x 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en face images, and qualitative information was compared to fluorescein angiography (FA) images. RESULTS: OMAG detected abnormal microvasculature in all MacTel2 eyes, predominantly in the middle retinal layers with neovascularization in the outer retina. These vessels correlated well with the FA alterations. The abnormal temporal, juxtafoveal microvasculature in MacTel2 became apparent as the disease progressed and in later stages tended to extend circumferentially, with anastomotic vessels temporally. CONCLUSION: OMAG provided detailed, depth-resolved information about the perifoveal macular microvasculature in MacTel2. In most cases, images were better using OMAG than FA. The OMAG images demonstrated that most of the leakage seen on FA appeared to arise from the abnormal perifoveal microvasculature in the middle retinal layer.

UR - http://www.scopus.com/inward/record.url?scp=84911409171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911409171&partnerID=8YFLogxK

U2 - 10.3928/23258160-20140909-06

DO - 10.3928/23258160-20140909-06

M3 - Article

C2 - 25291783

AN - SCOPUS:84911409171

VL - 45

SP - 369

EP - 380

JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

SN - 2325-8160

IS - 5

ER -