Swept-source OCT angiography of macular telangiectasia type 2

Mariana R. Thorell, Qinqin Zhang, Yanping Huang, Lin An, Mary K. Durbin, Michal Laron, Utkarsh Sharma, Paul F. Stetson, Giovanni Gregori, Ruikang K. Wang, Philip J. Rosenfeld

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


BACKGROUND AND OBJECTIVE: To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG). PATIENTS AND METHODS: Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm x 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en face images, and qualitative information was compared to fluorescein angiography (FA) images. RESULTS: OMAG detected abnormal microvasculature in all MacTel2 eyes, predominantly in the middle retinal layers with neovascularization in the outer retina. These vessels correlated well with the FA alterations. The abnormal temporal, juxtafoveal microvasculature in MacTel2 became apparent as the disease progressed and in later stages tended to extend circumferentially, with anastomotic vessels temporally. CONCLUSION: OMAG provided detailed, depth-resolved information about the perifoveal macular microvasculature in MacTel2. In most cases, images were better using OMAG than FA. The OMAG images demonstrated that most of the leakage seen on FA appeared to arise from the abnormal perifoveal microvasculature in the middle retinal layer.

Original languageEnglish (US)
Pages (from-to)369-380
Number of pages12
JournalOphthalmic Surgery Lasers and Imaging Retina
Issue number5
StatePublished - Sep 1 2014

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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