Sweat mechanisms and dysfunctions in atopic dermatitis

Aleksi J. Hendricks, Alexandra R. Vaughn, Ashley K. Clark, Gil Yosipovitch, Vivian Y. Shi

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Skin barrier dysfunction is inherent to atopic dermatitis (AD), causing dryness, irritation, and increased permeability to irritants, allergens and pathogens. Eccrine sweat functions as part of the skin's protective barrier. Variations in sweat responses have been observed in patients with AD, and altered sweat composition and dynamics are under-recognized as important factors in the disease cycle. This review discusses the role that sweat plays in the pathogenesis of AD, examines evidence on abnormal sweat composition, secretion, and neuro-immune responses to sweat in atopic skin, and highlights the value of sweat management.

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalJournal of dermatological science
Issue number2
StatePublished - Feb 2018


  • Atopic dermatitis
  • Eccrine sweat
  • Sweat and itch
  • Sweat management

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology


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