Sustainable data and metadata management at the BD2K-LINCS Data coordination and integration center

Vasileios Stathias, Amar Koleti, Dusica Vidovic, Daniel J. Cooper, Kathleen M. Jagodnik, Raymond Terryn, Michele Forlin, Caty Chung, Denis Torre, Nagi Ayad, Mario Medvedovic, Avi Ma'Ayan, Ajay Pillai, Stephan C. Schurer

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The NIH-funded LINCS Consortium is creating an extensive reference library of cell-based perturbation response signatures and sophisticated informatics tools incorporating a large number of perturbagens, model systems, and assays. To date, more than 350 datasets have been generated including transcriptomics, proteomics, epigenomics, cell phenotype and competitive binding profiling assays. The large volume and variety of data necessitate rigorous data standards and effective data management including modular data processing pipelines and end-user interfaces to facilitate accurate and reliable data exchange, curation, validation, standardization, aggregation, integration, and end user access. Deep metadata annotations and the use of qualified data standards enable integration with many external resources. Here we describe the end-to-end data processing and management at the DCIC to generate a high-quality and persistent product. Our data management and stewardship solutions enable a functioning Consortium and make LINCS a valuable scientific resource that aligns with big data initiatives such as the BD2K NIH Program and concords with emerging data science best practices including the findable, accessible, interoperable, and reusable (FAIR) principles.

Original languageEnglish (US)
Article number180117
JournalScientific Data
StatePublished - Jun 19 2018

ASJC Scopus subject areas

  • Statistics and Probability
  • Information Systems
  • Education
  • Computer Science Applications
  • Statistics, Probability and Uncertainty
  • Library and Information Sciences


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