Susceptibility of urothelium to neoplastic cellular implantation

Thomas E. Weldon; Mark S. Soloway

doi:10.1016/0090-4295(75)90367-2

Susceptibility of urothelium to neoplastic cellular implantation

Thomas E. Weldon, Mark S. Soloway

Urology

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.

Original language	English (US)
Pages (from-to)	824-827
Number of pages	4
Journal	Urology
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/0090-4295(75)90367-2
State	Published - Jun 1975

ASJC Scopus subject areas

Urology

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title = "Susceptibility of urothelium to neoplastic cellular implantation",

abstract = "This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.",

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AB - This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.

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