Susceptibility of urothelium to neoplastic cellular implantation

Thomas E. Weldon, Mark S. Soloway

Research output: Contribution to journalArticlepeer-review

109 Scopus citations


This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.

Original languageEnglish (US)
Pages (from-to)824-827
Number of pages4
Issue number6
StatePublished - Jun 1975

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'Susceptibility of urothelium to neoplastic cellular implantation'. Together they form a unique fingerprint.

Cite this