Abstract
This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 824-827 |
| Number of pages | 4 |
| Journal | Urology |
| Volume | 5 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1975 |
ASJC Scopus subject areas
- Urology
Fingerprint Dive into the research topics of 'Susceptibility of urothelium to neoplastic cellular implantation'. Together they form a unique fingerprint.
Cite this
Weldon, T. E., & Soloway, M. S. (1975). Susceptibility of urothelium to neoplastic cellular implantation. Urology, 5(6), 824-827. https://doi.org/10.1016/0090-4295(75)90367-2