Abstract
This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.
| Original language | English |
|---|---|
| Pages (from-to) | 824-827 |
| Number of pages | 4 |
| Journal | Urology |
| Volume | 5 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Urology
Cite this
Susceptibility of urothelium to neoplastic cellular implantation. / Weldon, Thomas E.; Soloway, Mark S.
In: Urology, Vol. 5, No. 6, 01.01.1975, p. 824-827.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Susceptibility of urothelium to neoplastic cellular implantation
AU - Weldon, Thomas E.
AU - Soloway, Mark S.
PY - 1975/1/1
Y1 - 1975/1/1
N2 - This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.
AB - This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.
UR - http://www.scopus.com/inward/record.url?scp=0016515419&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016515419&partnerID=8YFLogxK
U2 - 10.1016/0090-4295(75)90367-2
DO - 10.1016/0090-4295(75)90367-2
M3 - Article
C2 - 1136099
AN - SCOPUS:0016515419
VL - 5
SP - 824
EP - 827
JO - Urology
JF - Urology
SN - 0090-4295
IS - 6
ER -