Susceptibility of urothelium to neoplastic cellular implantation

Thomas E. Weldon; Mark S. Soloway

doi:10.1016/0090-4295(75)90367-2

Susceptibility of urothelium to neoplastic cellular implantation

Thomas E. Weldon, Mark S. Soloway

Urology

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98 Scopus citations

Abstract

This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.

Original language	English (US)
Pages (from-to)	824-827
Number of pages	4
Journal	Urology
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/0090-4295(75)90367-2
State	Published - Jun 1975

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ASJC Scopus subject areas

Urology

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Weldon, T. E., & Soloway, M. S. (1975). Susceptibility of urothelium to neoplastic cellular implantation. Urology, 5(6), 824-827. https://doi.org/10.1016/0090-4295(75)90367-2

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10.1016/0090-4295(75)90367-2