Susceptibility of urothelium to neoplastic cellular implantation

Thomas E. Weldon, Mark S. Soloway

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

This study sought to determine whether or not transitional carcinoma cells can adhere and progressively grow on normal or inflamed bladder urothelium. Inflammation was produced by intravesical N-methyl-N-nitrosourea. Tumor cell implantation occurred in only 13 per cent of mice with normal bladder, whereas in the presence of an altered urothelial surface there was a 60 per cent incidence of tumors. This study not only has clinical implications but also offers a model to investigate modalities to prevent tumor cell implantation.

Original languageEnglish
Pages (from-to)824-827
Number of pages4
JournalUrology
Volume5
Issue number6
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

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Urothelium
Urinary Bladder
Methylnitrosourea
Neoplasms
Transitional Cell Carcinoma
Inflammation
Incidence

ASJC Scopus subject areas

  • Urology

Cite this

Susceptibility of urothelium to neoplastic cellular implantation. / Weldon, Thomas E.; Soloway, Mark S.

In: Urology, Vol. 5, No. 6, 01.01.1975, p. 824-827.

Research output: Contribution to journalArticle

Weldon, Thomas E. ; Soloway, Mark S. / Susceptibility of urothelium to neoplastic cellular implantation. In: Urology. 1975 ; Vol. 5, No. 6. pp. 824-827.
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