Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV)

Stephen Dewhurst, Joel Bresser, Mario Stevenson, Koji Sakai, Mary Jean Evinger-Hodges, David J. Volsky

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Three human brain-derived cell lines (including two of astrocytic origin) were exposed in vitro to the human immunodeficiency virus (HIV), the etiologic agent of immunodeficiency in AIDS. In all three lines, HIV transcripts were detected by in situ hybridisation in 20-30% of cells 48 h afterinfection. Synthesis of virus gag gene products p24 and p55 was demonstrated by immunoblotting. No cytopathic effects typical of HIV-infected human T lymphocytes were observed. Our data indicate that HIV is neurotropic, and support the hypothesis that this virus may infect astrocytes in the brain.

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalFEBS letters
Volume213
Issue number1
DOIs
StatePublished - Mar 9 1987
Externally publishedYes

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Keywords

  • AIDS
  • Astrocyte
  • Central nervous system
  • Glial fibrillary acidic protein
  • HIV receptor
  • Human immunodeficiency virus

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Dewhurst, S., Bresser, J., Stevenson, M., Sakai, K., Evinger-Hodges, M. J., & Volsky, D. J. (1987). Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV). FEBS letters, 213(1), 138-143. https://doi.org/10.1016/0014-5793(87)81479-5