Susceptibility locus for Alzheimer's disease on chromosome 10

Amanda J Myers, P. Holmans, H. Marshall, J. Kwon, D. Meyer, D. Ramic, S. Shears, J. Booth, F. W. DeVrieze, R. Crook, M. Hamshere, R. Abraham, N. Tunstall, F. Rice, S. Carty, S. Lillystone, P. Kehoe, V. Rudrasingham, L. Jones, S. Lovestone & 5 others J. Perez-Tur, J. Williams, M. J. Owen, J. Hardy, A. M. Goate

Research output: Contribution to journalArticle

331 Citations (Scopus)

Abstract

The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.

Original languageEnglish
Pages (from-to)2304-2305
Number of pages2
JournalScience
Volume290
Issue number5500
DOIs
StatePublished - Dec 22 2000
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 10
Alzheimer Disease
Apolipoproteins E
Lod Score
Alleles
Odds Ratio
Genotype
Genome
Genes

ASJC Scopus subject areas

  • General

Cite this

Myers, A. J., Holmans, P., Marshall, H., Kwon, J., Meyer, D., Ramic, D., ... Goate, A. M. (2000). Susceptibility locus for Alzheimer's disease on chromosome 10. Science, 290(5500), 2304-2305. https://doi.org/10.1126/science.290.5500.2304

Susceptibility locus for Alzheimer's disease on chromosome 10. / Myers, Amanda J; Holmans, P.; Marshall, H.; Kwon, J.; Meyer, D.; Ramic, D.; Shears, S.; Booth, J.; DeVrieze, F. W.; Crook, R.; Hamshere, M.; Abraham, R.; Tunstall, N.; Rice, F.; Carty, S.; Lillystone, S.; Kehoe, P.; Rudrasingham, V.; Jones, L.; Lovestone, S.; Perez-Tur, J.; Williams, J.; Owen, M. J.; Hardy, J.; Goate, A. M.

In: Science, Vol. 290, No. 5500, 22.12.2000, p. 2304-2305.

Research output: Contribution to journalArticle

Myers, AJ, Holmans, P, Marshall, H, Kwon, J, Meyer, D, Ramic, D, Shears, S, Booth, J, DeVrieze, FW, Crook, R, Hamshere, M, Abraham, R, Tunstall, N, Rice, F, Carty, S, Lillystone, S, Kehoe, P, Rudrasingham, V, Jones, L, Lovestone, S, Perez-Tur, J, Williams, J, Owen, MJ, Hardy, J & Goate, AM 2000, 'Susceptibility locus for Alzheimer's disease on chromosome 10', Science, vol. 290, no. 5500, pp. 2304-2305. https://doi.org/10.1126/science.290.5500.2304
Myers AJ, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D et al. Susceptibility locus for Alzheimer's disease on chromosome 10. Science. 2000 Dec 22;290(5500):2304-2305. https://doi.org/10.1126/science.290.5500.2304
Myers, Amanda J ; Holmans, P. ; Marshall, H. ; Kwon, J. ; Meyer, D. ; Ramic, D. ; Shears, S. ; Booth, J. ; DeVrieze, F. W. ; Crook, R. ; Hamshere, M. ; Abraham, R. ; Tunstall, N. ; Rice, F. ; Carty, S. ; Lillystone, S. ; Kehoe, P. ; Rudrasingham, V. ; Jones, L. ; Lovestone, S. ; Perez-Tur, J. ; Williams, J. ; Owen, M. J. ; Hardy, J. ; Goate, A. M. / Susceptibility locus for Alzheimer's disease on chromosome 10. In: Science. 2000 ; Vol. 290, No. 5500. pp. 2304-2305.
@article{2ab466c153ee4e16a41c14906f176fb1,
title = "Susceptibility locus for Alzheimer's disease on chromosome 10",
abstract = "The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.",
author = "Myers, {Amanda J} and P. Holmans and H. Marshall and J. Kwon and D. Meyer and D. Ramic and S. Shears and J. Booth and DeVrieze, {F. W.} and R. Crook and M. Hamshere and R. Abraham and N. Tunstall and F. Rice and S. Carty and S. Lillystone and P. Kehoe and V. Rudrasingham and L. Jones and S. Lovestone and J. Perez-Tur and J. Williams and Owen, {M. J.} and J. Hardy and Goate, {A. M.}",
year = "2000",
month = "12",
day = "22",
doi = "10.1126/science.290.5500.2304",
language = "English",
volume = "290",
pages = "2304--2305",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5500",

}

TY - JOUR

T1 - Susceptibility locus for Alzheimer's disease on chromosome 10

AU - Myers, Amanda J

AU - Holmans, P.

AU - Marshall, H.

AU - Kwon, J.

AU - Meyer, D.

AU - Ramic, D.

AU - Shears, S.

AU - Booth, J.

AU - DeVrieze, F. W.

AU - Crook, R.

AU - Hamshere, M.

AU - Abraham, R.

AU - Tunstall, N.

AU - Rice, F.

AU - Carty, S.

AU - Lillystone, S.

AU - Kehoe, P.

AU - Rudrasingham, V.

AU - Jones, L.

AU - Lovestone, S.

AU - Perez-Tur, J.

AU - Williams, J.

AU - Owen, M. J.

AU - Hardy, J.

AU - Goate, A. M.

PY - 2000/12/22

Y1 - 2000/12/22

N2 - The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.

AB - The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.

UR - http://www.scopus.com/inward/record.url?scp=0034704197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034704197&partnerID=8YFLogxK

U2 - 10.1126/science.290.5500.2304

DO - 10.1126/science.290.5500.2304

M3 - Article

VL - 290

SP - 2304

EP - 2305

JO - Science

JF - Science

SN - 0036-8075

IS - 5500

ER -