Abstract
Several studies have shown reliable predictive factors for outcome in status epilepticus (SE), especially etiology and presentation in coma. Duration of SE is predictive, but probably only in the first few hours, and there have been many reports of patients treated successfully for SE lasting many days or weeks. Nevertheless, there are many other patients with SE treated for prolonged periods without success, sometimes apparently futilely. We compared clinical features of 10 survivors of prolonged SE with those of a matched cohort treated for similarly prolonged episodes but unsuccessfully, looking for exceptions to known predictive factors. Multiple medical problems (i.e., etiologies) and coma on presentation were confirmed as predictors of a poor outcome. Analysis of individual exceptions to these predictors showed that age, overall background health, and family input on the value of prolonged treatment, on the one hand, and earlier epilepsy plus rapid and accurate diagnosis and treatment, on the other, contributed to results different from what would have been expected.
| Original language | English |
|---|---|
| Pages (from-to) | 342-345 |
| Number of pages | 4 |
| Journal | Epilepsy and Behavior |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 1 2011 |
| Externally published | Yes |
Fingerprint
Keywords
- Coma
- Futility
- Intensive care unit
- Nonconvulsive status epilepticus
- Predictive factors
- Prognosis
- Status epilepticus
- Treatment
ASJC Scopus subject areas
- Clinical Neurology
- Behavioral Neuroscience
- Neurology
Cite this
Survivors and nonsurvivors of very prolonged status epilepticus. / Drislane, Frank W.; Lopez, M. Raquel; Blum, Andrew S.; Schomer, Donald L.
In: Epilepsy and Behavior, Vol. 22, No. 2, 01.10.2011, p. 342-345.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Survivors and nonsurvivors of very prolonged status epilepticus
AU - Drislane, Frank W.
AU - Lopez, M. Raquel
AU - Blum, Andrew S.
AU - Schomer, Donald L.
PY - 2011/10/1
Y1 - 2011/10/1
N2 - Several studies have shown reliable predictive factors for outcome in status epilepticus (SE), especially etiology and presentation in coma. Duration of SE is predictive, but probably only in the first few hours, and there have been many reports of patients treated successfully for SE lasting many days or weeks. Nevertheless, there are many other patients with SE treated for prolonged periods without success, sometimes apparently futilely. We compared clinical features of 10 survivors of prolonged SE with those of a matched cohort treated for similarly prolonged episodes but unsuccessfully, looking for exceptions to known predictive factors. Multiple medical problems (i.e., etiologies) and coma on presentation were confirmed as predictors of a poor outcome. Analysis of individual exceptions to these predictors showed that age, overall background health, and family input on the value of prolonged treatment, on the one hand, and earlier epilepsy plus rapid and accurate diagnosis and treatment, on the other, contributed to results different from what would have been expected.
AB - Several studies have shown reliable predictive factors for outcome in status epilepticus (SE), especially etiology and presentation in coma. Duration of SE is predictive, but probably only in the first few hours, and there have been many reports of patients treated successfully for SE lasting many days or weeks. Nevertheless, there are many other patients with SE treated for prolonged periods without success, sometimes apparently futilely. We compared clinical features of 10 survivors of prolonged SE with those of a matched cohort treated for similarly prolonged episodes but unsuccessfully, looking for exceptions to known predictive factors. Multiple medical problems (i.e., etiologies) and coma on presentation were confirmed as predictors of a poor outcome. Analysis of individual exceptions to these predictors showed that age, overall background health, and family input on the value of prolonged treatment, on the one hand, and earlier epilepsy plus rapid and accurate diagnosis and treatment, on the other, contributed to results different from what would have been expected.
KW - Coma
KW - Futility
KW - Intensive care unit
KW - Nonconvulsive status epilepticus
KW - Predictive factors
KW - Prognosis
KW - Status epilepticus
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=80053386940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053386940&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2011.07.013
DO - 10.1016/j.yebeh.2011.07.013
M3 - Article
C2 - 21840765
AN - SCOPUS:80053386940
VL - 22
SP - 342
EP - 345
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
IS - 2
ER -