Survival trends in European cancer patients diagnosed from 1988 to 1999

Arduino Verdecchia, Stefano Guzzinati, Silvia Francisci, Roberta De Angelis, Freddie Bray, Claudia Allemani, Andrea Tavilla, Mariano Santaquilani, Milena Sant, A. Gavin, R. J. Black, D. H. Brewster, J. A. Steward, W. Oberaigner, M. Hackl, E. Van Eycken, Martine Verstreken, J. Holub, L. Jurickova, H. H. StormG. Engholm, T. Hakulinen, A. Belot, G. Hédelin, M. Velten, I. Tron, E. Le Gall, G. Launoy, A. V. Guizard, J. Faivre, A. M. Bouvier, P. M. Carli, M. Maynadié, A. Danzon, A. Buemi, B. Tretarre, B. Lacour, E. Desandes, M. Colonna, F. Molinié, S. Bara, C. Schvartz, O. Ganry, P. Grosclaude, H. Brenner, P. Kaatsch, H. Ziegler, L. Tryggvadottir, H. Comber, F. Berrino, P. Baili, R. Ciampichini, L. Ciccolallo, G. Gatta, A. Micheli, S. Sowe, G. Zigon, G. Tagliabue, P. Contiero, F. Bellù, A. Giacomin, S. Ferretti, D. Serraino L. Dal Maso, M. De Dottori, A. De Paoli, L. Zanier, M. Vercelli, M. A. Orengo, C. Casella, A. Quaglia, F. Pannelli, M. Federico, I. Rashid, C. Cirilli, M. Fusco, A. Traina, V. De Lisi, F. Bozzani, C. Magnani, G. Pastore, R. Tumino, M. G. La Rosa, E. Spata, A. Sigona, L. Mangone, F. Falcini, F. Foca, S. Giorgetti, G. Senatore, A. Iannelli, M. Budroni, R. Zanetti, S. Patriarca, S. Rosso, S. Piffer, S. Franchini, E. Paci, E. Crocetti, F. La Rosa, F. Stracci, T. Cassetti, P. Zambon, M. Caldora, R. Capocaccia, E. Carrani, E. Grande, R. Inghelmann, H. Lenz, L. Martina, P. Roazzi, A. Simonetti, M. Dalmas, F. Langmark, T. B. Johannesen, J. Rachtan, S. Góźdź, U. Siudowska, R. Mȩzyk, M. Bielska-Lasota, M. Zwierko, Paulo Pinheiro, M. P.Z. Primic-Žakelj, A. Mateos, I. Izarzugaza, A. Torrella-Ramos, Oscar Zurriaga, R. Marcos-Gragera, M. L. Vilardell, A. Izquierdo, C. Martinez-Garcia, M. J. Sánchez, C. Navarro, M. D. Chirlaque, R. Peris-Bonet, E. Ardanaz, C. Moreno, J. Galceran, Klint, M. Talbäck, G. Jundt, M. Usel, H. Frick, S. M. Ess, A. Bordoni, J. C. Luthi, I. Konzelmann, N. Probst, J. M. Lutz, P. Pury, O. Visser, R. Otter, M. Schaapveld, J. W.W. Coebergh, M. L. Janssen-Heijnen, Louis Van Der Heijden, D. C. Greenberg, M. P. Coleman, Laura Woods, T. Moran, D. Forman, N. Cooper, M. Roche, J. Verne, H. Møller, D. Meechan, J. Poole, G. Lawrence, C. Stiller

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

We analysed data from 49 cancer registries in 18 European countries over the period 1988- 1999 to delineate time trends in cancer survival. Survival increased in Europe over the study period for all cancer sites that were considered. There were major survival increases in 5 year age-adjusted relative survival for prostate (from 58% to 79%), colon and rectum (from 48% to 54% men and women), and breast (from 74% to 83%). Improvements were also significant for stomach (from 22% to 24%), male larynx (from 62% to 64%), skin melanoma (from 78% to 83%), Hodgkin disease (from 77% to 83%), non-Hodgkin lymphoma (from 49% to 56%), leukaemias (from 37% to 42%), and for all cancers combined (from 34% to 39% in men, and from 52% to 59% in women). Survival did not change significantly for female larynx, lung, cervix or ovary. The largest increases in survival typically occurred in countries with the lowest survival, and contributed to the overall reduction of survival disparities across Europe over the study period. Differences in the extent of PSA testing and mammographic screening, and increasing use of colonscopy and faecal blood testing together with improving cancer care are probably the major underlying reasons for the improvements in survival for cancers of prostate, breast, colon and rectum. The marked survival improvements in countries with poor survival may indicate that these countries have made efforts to adopt the new diagnostic procedures and the standardised therapeutic protocols in use in more affluent countries.

Original languageEnglish (US)
Pages (from-to)1042-1066
Number of pages25
JournalEuropean Journal of Cancer
Volume45
Issue number6
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

Fingerprint

Survival
Neoplasms
Larynx
Colon
Rectal Neoplasms
Hodgkin Disease
Rectum
Cervix Uteri
Non-Hodgkin's Lymphoma
Registries
Prostate
Ovary
Melanoma
Prostatic Neoplasms
Stomach
Leukemia
Breast
Breast Neoplasms
Lung
Skin

Keywords

  • Europe
  • Neoplasms
  • Population registries
  • Survival
  • Time trends

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Verdecchia, A., Guzzinati, S., Francisci, S., De Angelis, R., Bray, F., Allemani, C., ... Stiller, C. (2009). Survival trends in European cancer patients diagnosed from 1988 to 1999. European Journal of Cancer, 45(6), 1042-1066. https://doi.org/10.1016/j.ejca.2008.11.029

Survival trends in European cancer patients diagnosed from 1988 to 1999. / Verdecchia, Arduino; Guzzinati, Stefano; Francisci, Silvia; De Angelis, Roberta; Bray, Freddie; Allemani, Claudia; Tavilla, Andrea; Santaquilani, Mariano; Sant, Milena; Gavin, A.; Black, R. J.; Brewster, D. H.; Steward, J. A.; Oberaigner, W.; Hackl, M.; Van Eycken, E.; Verstreken, Martine; Holub, J.; Jurickova, L.; Storm, H. H.; Engholm, G.; Hakulinen, T.; Belot, A.; Hédelin, G.; Velten, M.; Tron, I.; Le Gall, E.; Launoy, G.; Guizard, A. V.; Faivre, J.; Bouvier, A. M.; Carli, P. M.; Maynadié, M.; Danzon, A.; Buemi, A.; Tretarre, B.; Lacour, B.; Desandes, E.; Colonna, M.; Molinié, F.; Bara, S.; Schvartz, C.; Ganry, O.; Grosclaude, P.; Brenner, H.; Kaatsch, P.; Ziegler, H.; Tryggvadottir, L.; Comber, H.; Berrino, F.; Baili, P.; Ciampichini, R.; Ciccolallo, L.; Gatta, G.; Micheli, A.; Sowe, S.; Zigon, G.; Tagliabue, G.; Contiero, P.; Bellù, F.; Giacomin, A.; Ferretti, S.; Dal Maso, D. Serraino L.; De Dottori, M.; De Paoli, A.; Zanier, L.; Vercelli, M.; Orengo, M. A.; Casella, C.; Quaglia, A.; Pannelli, F.; Federico, M.; Rashid, I.; Cirilli, C.; Fusco, M.; Traina, A.; De Lisi, V.; Bozzani, F.; Magnani, C.; Pastore, G.; Tumino, R.; La Rosa, M. G.; Spata, E.; Sigona, A.; Mangone, L.; Falcini, F.; Foca, F.; Giorgetti, S.; Senatore, G.; Iannelli, A.; Budroni, M.; Zanetti, R.; Patriarca, S.; Rosso, S.; Piffer, S.; Franchini, S.; Paci, E.; Crocetti, E.; La Rosa, F.; Stracci, F.; Cassetti, T.; Zambon, P.; Caldora, M.; Capocaccia, R.; Carrani, E.; Grande, E.; Inghelmann, R.; Lenz, H.; Martina, L.; Roazzi, P.; Simonetti, A.; Dalmas, M.; Langmark, F.; Johannesen, T. B.; Rachtan, J.; Góźdź, S.; Siudowska, U.; Mȩzyk, R.; Bielska-Lasota, M.; Zwierko, M.; Pinheiro, Paulo; Primic-Žakelj, M. P.Z.; Mateos, A.; Izarzugaza, I.; Torrella-Ramos, A.; Zurriaga, Oscar; Marcos-Gragera, R.; Vilardell, M. L.; Izquierdo, A.; Martinez-Garcia, C.; Sánchez, M. J.; Navarro, C.; Chirlaque, M. D.; Peris-Bonet, R.; Ardanaz, E.; Moreno, C.; Galceran, J.; Klint; Talbäck, M.; Jundt, G.; Usel, M.; Frick, H.; Ess, S. M.; Bordoni, A.; Luthi, J. C.; Konzelmann, I.; Probst, N.; Lutz, J. M.; Pury, P.; Visser, O.; Otter, R.; Schaapveld, M.; Coebergh, J. W.W.; Janssen-Heijnen, M. L.; Van Der Heijden, Louis; Greenberg, D. C.; Coleman, M. P.; Woods, Laura; Moran, T.; Forman, D.; Cooper, N.; Roche, M.; Verne, J.; Møller, H.; Meechan, D.; Poole, J.; Lawrence, G.; Stiller, C.

In: European Journal of Cancer, Vol. 45, No. 6, 01.04.2009, p. 1042-1066.

Research output: Contribution to journalArticle

Verdecchia, A, Guzzinati, S, Francisci, S, De Angelis, R, Bray, F, Allemani, C, Tavilla, A, Santaquilani, M, Sant, M, Gavin, A, Black, RJ, Brewster, DH, Steward, JA, Oberaigner, W, Hackl, M, Van Eycken, E, Verstreken, M, Holub, J, Jurickova, L, Storm, HH, Engholm, G, Hakulinen, T, Belot, A, Hédelin, G, Velten, M, Tron, I, Le Gall, E, Launoy, G, Guizard, AV, Faivre, J, Bouvier, AM, Carli, PM, Maynadié, M, Danzon, A, Buemi, A, Tretarre, B, Lacour, B, Desandes, E, Colonna, M, Molinié, F, Bara, S, Schvartz, C, Ganry, O, Grosclaude, P, Brenner, H, Kaatsch, P, Ziegler, H, Tryggvadottir, L, Comber, H, Berrino, F, Baili, P, Ciampichini, R, Ciccolallo, L, Gatta, G, Micheli, A, Sowe, S, Zigon, G, Tagliabue, G, Contiero, P, Bellù, F, Giacomin, A, Ferretti, S, Dal Maso, DSL, De Dottori, M, De Paoli, A, Zanier, L, Vercelli, M, Orengo, MA, Casella, C, Quaglia, A, Pannelli, F, Federico, M, Rashid, I, Cirilli, C, Fusco, M, Traina, A, De Lisi, V, Bozzani, F, Magnani, C, Pastore, G, Tumino, R, La Rosa, MG, Spata, E, Sigona, A, Mangone, L, Falcini, F, Foca, F, Giorgetti, S, Senatore, G, Iannelli, A, Budroni, M, Zanetti, R, Patriarca, S, Rosso, S, Piffer, S, Franchini, S, Paci, E, Crocetti, E, La Rosa, F, Stracci, F, Cassetti, T, Zambon, P, Caldora, M, Capocaccia, R, Carrani, E, Grande, E, Inghelmann, R, Lenz, H, Martina, L, Roazzi, P, Simonetti, A, Dalmas, M, Langmark, F, Johannesen, TB, Rachtan, J, Góźdź, S, Siudowska, U, Mȩzyk, R, Bielska-Lasota, M, Zwierko, M, Pinheiro, P, Primic-Žakelj, MPZ, Mateos, A, Izarzugaza, I, Torrella-Ramos, A, Zurriaga, O, Marcos-Gragera, R, Vilardell, ML, Izquierdo, A, Martinez-Garcia, C, Sánchez, MJ, Navarro, C, Chirlaque, MD, Peris-Bonet, R, Ardanaz, E, Moreno, C, Galceran, J, Klint, Talbäck, M, Jundt, G, Usel, M, Frick, H, Ess, SM, Bordoni, A, Luthi, JC, Konzelmann, I, Probst, N, Lutz, JM, Pury, P, Visser, O, Otter, R, Schaapveld, M, Coebergh, JWW, Janssen-Heijnen, ML, Van Der Heijden, L, Greenberg, DC, Coleman, MP, Woods, L, Moran, T, Forman, D, Cooper, N, Roche, M, Verne, J, Møller, H, Meechan, D, Poole, J, Lawrence, G & Stiller, C 2009, 'Survival trends in European cancer patients diagnosed from 1988 to 1999', European Journal of Cancer, vol. 45, no. 6, pp. 1042-1066. https://doi.org/10.1016/j.ejca.2008.11.029
Verdecchia A, Guzzinati S, Francisci S, De Angelis R, Bray F, Allemani C et al. Survival trends in European cancer patients diagnosed from 1988 to 1999. European Journal of Cancer. 2009 Apr 1;45(6):1042-1066. https://doi.org/10.1016/j.ejca.2008.11.029
Verdecchia, Arduino ; Guzzinati, Stefano ; Francisci, Silvia ; De Angelis, Roberta ; Bray, Freddie ; Allemani, Claudia ; Tavilla, Andrea ; Santaquilani, Mariano ; Sant, Milena ; Gavin, A. ; Black, R. J. ; Brewster, D. H. ; Steward, J. A. ; Oberaigner, W. ; Hackl, M. ; Van Eycken, E. ; Verstreken, Martine ; Holub, J. ; Jurickova, L. ; Storm, H. H. ; Engholm, G. ; Hakulinen, T. ; Belot, A. ; Hédelin, G. ; Velten, M. ; Tron, I. ; Le Gall, E. ; Launoy, G. ; Guizard, A. V. ; Faivre, J. ; Bouvier, A. M. ; Carli, P. M. ; Maynadié, M. ; Danzon, A. ; Buemi, A. ; Tretarre, B. ; Lacour, B. ; Desandes, E. ; Colonna, M. ; Molinié, F. ; Bara, S. ; Schvartz, C. ; Ganry, O. ; Grosclaude, P. ; Brenner, H. ; Kaatsch, P. ; Ziegler, H. ; Tryggvadottir, L. ; Comber, H. ; Berrino, F. ; Baili, P. ; Ciampichini, R. ; Ciccolallo, L. ; Gatta, G. ; Micheli, A. ; Sowe, S. ; Zigon, G. ; Tagliabue, G. ; Contiero, P. ; Bellù, F. ; Giacomin, A. ; Ferretti, S. ; Dal Maso, D. Serraino L. ; De Dottori, M. ; De Paoli, A. ; Zanier, L. ; Vercelli, M. ; Orengo, M. A. ; Casella, C. ; Quaglia, A. ; Pannelli, F. ; Federico, M. ; Rashid, I. ; Cirilli, C. ; Fusco, M. ; Traina, A. ; De Lisi, V. ; Bozzani, F. ; Magnani, C. ; Pastore, G. ; Tumino, R. ; La Rosa, M. G. ; Spata, E. ; Sigona, A. ; Mangone, L. ; Falcini, F. ; Foca, F. ; Giorgetti, S. ; Senatore, G. ; Iannelli, A. ; Budroni, M. ; Zanetti, R. ; Patriarca, S. ; Rosso, S. ; Piffer, S. ; Franchini, S. ; Paci, E. ; Crocetti, E. ; La Rosa, F. ; Stracci, F. ; Cassetti, T. ; Zambon, P. ; Caldora, M. ; Capocaccia, R. ; Carrani, E. ; Grande, E. ; Inghelmann, R. ; Lenz, H. ; Martina, L. ; Roazzi, P. ; Simonetti, A. ; Dalmas, M. ; Langmark, F. ; Johannesen, T. B. ; Rachtan, J. ; Góźdź, S. ; Siudowska, U. ; Mȩzyk, R. ; Bielska-Lasota, M. ; Zwierko, M. ; Pinheiro, Paulo ; Primic-Žakelj, M. P.Z. ; Mateos, A. ; Izarzugaza, I. ; Torrella-Ramos, A. ; Zurriaga, Oscar ; Marcos-Gragera, R. ; Vilardell, M. L. ; Izquierdo, A. ; Martinez-Garcia, C. ; Sánchez, M. J. ; Navarro, C. ; Chirlaque, M. D. ; Peris-Bonet, R. ; Ardanaz, E. ; Moreno, C. ; Galceran, J. ; Klint ; Talbäck, M. ; Jundt, G. ; Usel, M. ; Frick, H. ; Ess, S. M. ; Bordoni, A. ; Luthi, J. C. ; Konzelmann, I. ; Probst, N. ; Lutz, J. M. ; Pury, P. ; Visser, O. ; Otter, R. ; Schaapveld, M. ; Coebergh, J. W.W. ; Janssen-Heijnen, M. L. ; Van Der Heijden, Louis ; Greenberg, D. C. ; Coleman, M. P. ; Woods, Laura ; Moran, T. ; Forman, D. ; Cooper, N. ; Roche, M. ; Verne, J. ; Møller, H. ; Meechan, D. ; Poole, J. ; Lawrence, G. ; Stiller, C. / Survival trends in European cancer patients diagnosed from 1988 to 1999. In: European Journal of Cancer. 2009 ; Vol. 45, No. 6. pp. 1042-1066.
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title = "Survival trends in European cancer patients diagnosed from 1988 to 1999",
abstract = "We analysed data from 49 cancer registries in 18 European countries over the period 1988- 1999 to delineate time trends in cancer survival. Survival increased in Europe over the study period for all cancer sites that were considered. There were major survival increases in 5 year age-adjusted relative survival for prostate (from 58{\%} to 79{\%}), colon and rectum (from 48{\%} to 54{\%} men and women), and breast (from 74{\%} to 83{\%}). Improvements were also significant for stomach (from 22{\%} to 24{\%}), male larynx (from 62{\%} to 64{\%}), skin melanoma (from 78{\%} to 83{\%}), Hodgkin disease (from 77{\%} to 83{\%}), non-Hodgkin lymphoma (from 49{\%} to 56{\%}), leukaemias (from 37{\%} to 42{\%}), and for all cancers combined (from 34{\%} to 39{\%} in men, and from 52{\%} to 59{\%} in women). Survival did not change significantly for female larynx, lung, cervix or ovary. The largest increases in survival typically occurred in countries with the lowest survival, and contributed to the overall reduction of survival disparities across Europe over the study period. Differences in the extent of PSA testing and mammographic screening, and increasing use of colonscopy and faecal blood testing together with improving cancer care are probably the major underlying reasons for the improvements in survival for cancers of prostate, breast, colon and rectum. The marked survival improvements in countries with poor survival may indicate that these countries have made efforts to adopt the new diagnostic procedures and the standardised therapeutic protocols in use in more affluent countries.",
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TY - JOUR

T1 - Survival trends in European cancer patients diagnosed from 1988 to 1999

AU - Verdecchia, Arduino

AU - Guzzinati, Stefano

AU - Francisci, Silvia

AU - De Angelis, Roberta

AU - Bray, Freddie

AU - Allemani, Claudia

AU - Tavilla, Andrea

AU - Santaquilani, Mariano

AU - Sant, Milena

AU - Gavin, A.

AU - Black, R. J.

AU - Brewster, D. H.

AU - Steward, J. A.

AU - Oberaigner, W.

AU - Hackl, M.

AU - Van Eycken, E.

AU - Verstreken, Martine

AU - Holub, J.

AU - Jurickova, L.

AU - Storm, H. H.

AU - Engholm, G.

AU - Hakulinen, T.

AU - Belot, A.

AU - Hédelin, G.

AU - Velten, M.

AU - Tron, I.

AU - Le Gall, E.

AU - Launoy, G.

AU - Guizard, A. V.

AU - Faivre, J.

AU - Bouvier, A. M.

AU - Carli, P. M.

AU - Maynadié, M.

AU - Danzon, A.

AU - Buemi, A.

AU - Tretarre, B.

AU - Lacour, B.

AU - Desandes, E.

AU - Colonna, M.

AU - Molinié, F.

AU - Bara, S.

AU - Schvartz, C.

AU - Ganry, O.

AU - Grosclaude, P.

AU - Brenner, H.

AU - Kaatsch, P.

AU - Ziegler, H.

AU - Tryggvadottir, L.

AU - Comber, H.

AU - Berrino, F.

AU - Baili, P.

AU - Ciampichini, R.

AU - Ciccolallo, L.

AU - Gatta, G.

AU - Micheli, A.

AU - Sowe, S.

AU - Zigon, G.

AU - Tagliabue, G.

AU - Contiero, P.

AU - Bellù, F.

AU - Giacomin, A.

AU - Ferretti, S.

AU - Dal Maso, D. Serraino L.

AU - De Dottori, M.

AU - De Paoli, A.

AU - Zanier, L.

AU - Vercelli, M.

AU - Orengo, M. A.

AU - Casella, C.

AU - Quaglia, A.

AU - Pannelli, F.

AU - Federico, M.

AU - Rashid, I.

AU - Cirilli, C.

AU - Fusco, M.

AU - Traina, A.

AU - De Lisi, V.

AU - Bozzani, F.

AU - Magnani, C.

AU - Pastore, G.

AU - Tumino, R.

AU - La Rosa, M. G.

AU - Spata, E.

AU - Sigona, A.

AU - Mangone, L.

AU - Falcini, F.

AU - Foca, F.

AU - Giorgetti, S.

AU - Senatore, G.

AU - Iannelli, A.

AU - Budroni, M.

AU - Zanetti, R.

AU - Patriarca, S.

AU - Rosso, S.

AU - Piffer, S.

AU - Franchini, S.

AU - Paci, E.

AU - Crocetti, E.

AU - La Rosa, F.

AU - Stracci, F.

AU - Cassetti, T.

AU - Zambon, P.

AU - Caldora, M.

AU - Capocaccia, R.

AU - Carrani, E.

AU - Grande, E.

AU - Inghelmann, R.

AU - Lenz, H.

AU - Martina, L.

AU - Roazzi, P.

AU - Simonetti, A.

AU - Dalmas, M.

AU - Langmark, F.

AU - Johannesen, T. B.

AU - Rachtan, J.

AU - Góźdź, S.

AU - Siudowska, U.

AU - Mȩzyk, R.

AU - Bielska-Lasota, M.

AU - Zwierko, M.

AU - Pinheiro, Paulo

AU - Primic-Žakelj, M. P.Z.

AU - Mateos, A.

AU - Izarzugaza, I.

AU - Torrella-Ramos, A.

AU - Zurriaga, Oscar

AU - Marcos-Gragera, R.

AU - Vilardell, M. L.

AU - Izquierdo, A.

AU - Martinez-Garcia, C.

AU - Sánchez, M. J.

AU - Navarro, C.

AU - Chirlaque, M. D.

AU - Peris-Bonet, R.

AU - Ardanaz, E.

AU - Moreno, C.

AU - Galceran, J.

AU - Klint,

AU - Talbäck, M.

AU - Jundt, G.

AU - Usel, M.

AU - Frick, H.

AU - Ess, S. M.

AU - Bordoni, A.

AU - Luthi, J. C.

AU - Konzelmann, I.

AU - Probst, N.

AU - Lutz, J. M.

AU - Pury, P.

AU - Visser, O.

AU - Otter, R.

AU - Schaapveld, M.

AU - Coebergh, J. W.W.

AU - Janssen-Heijnen, M. L.

AU - Van Der Heijden, Louis

AU - Greenberg, D. C.

AU - Coleman, M. P.

AU - Woods, Laura

AU - Moran, T.

AU - Forman, D.

AU - Cooper, N.

AU - Roche, M.

AU - Verne, J.

AU - Møller, H.

AU - Meechan, D.

AU - Poole, J.

AU - Lawrence, G.

AU - Stiller, C.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - We analysed data from 49 cancer registries in 18 European countries over the period 1988- 1999 to delineate time trends in cancer survival. Survival increased in Europe over the study period for all cancer sites that were considered. There were major survival increases in 5 year age-adjusted relative survival for prostate (from 58% to 79%), colon and rectum (from 48% to 54% men and women), and breast (from 74% to 83%). Improvements were also significant for stomach (from 22% to 24%), male larynx (from 62% to 64%), skin melanoma (from 78% to 83%), Hodgkin disease (from 77% to 83%), non-Hodgkin lymphoma (from 49% to 56%), leukaemias (from 37% to 42%), and for all cancers combined (from 34% to 39% in men, and from 52% to 59% in women). Survival did not change significantly for female larynx, lung, cervix or ovary. The largest increases in survival typically occurred in countries with the lowest survival, and contributed to the overall reduction of survival disparities across Europe over the study period. Differences in the extent of PSA testing and mammographic screening, and increasing use of colonscopy and faecal blood testing together with improving cancer care are probably the major underlying reasons for the improvements in survival for cancers of prostate, breast, colon and rectum. The marked survival improvements in countries with poor survival may indicate that these countries have made efforts to adopt the new diagnostic procedures and the standardised therapeutic protocols in use in more affluent countries.

AB - We analysed data from 49 cancer registries in 18 European countries over the period 1988- 1999 to delineate time trends in cancer survival. Survival increased in Europe over the study period for all cancer sites that were considered. There were major survival increases in 5 year age-adjusted relative survival for prostate (from 58% to 79%), colon and rectum (from 48% to 54% men and women), and breast (from 74% to 83%). Improvements were also significant for stomach (from 22% to 24%), male larynx (from 62% to 64%), skin melanoma (from 78% to 83%), Hodgkin disease (from 77% to 83%), non-Hodgkin lymphoma (from 49% to 56%), leukaemias (from 37% to 42%), and for all cancers combined (from 34% to 39% in men, and from 52% to 59% in women). Survival did not change significantly for female larynx, lung, cervix or ovary. The largest increases in survival typically occurred in countries with the lowest survival, and contributed to the overall reduction of survival disparities across Europe over the study period. Differences in the extent of PSA testing and mammographic screening, and increasing use of colonscopy and faecal blood testing together with improving cancer care are probably the major underlying reasons for the improvements in survival for cancers of prostate, breast, colon and rectum. The marked survival improvements in countries with poor survival may indicate that these countries have made efforts to adopt the new diagnostic procedures and the standardised therapeutic protocols in use in more affluent countries.

KW - Europe

KW - Neoplasms

KW - Population registries

KW - Survival

KW - Time trends

UR - http://www.scopus.com/inward/record.url?scp=62549140540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62549140540&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2008.11.029

DO - 10.1016/j.ejca.2008.11.029

M3 - Article

C2 - 19124239

AN - SCOPUS:62549140540

VL - 45

SP - 1042

EP - 1066

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 6

ER -