Survival of patients with multiple primary malignancies: A study of 783 patients with gastrointestinal stromal tumor

R. K. Pandurengan, A. G. Dumont, D. M. Araujo, J. A. Ludwig, V. Ravi, S. Patel, J. Garber, R. S. Benjamin, S. S. Strom, Jonathan Trent

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Background: We sought to investigate the characteristics and survival rate of patients with gastrointestinal stromal tumor (GIST) associated with other primary malignancies. Patients and methods: A total of 783 patients with GIST were identified from 1995 to 2007. Additional primaries included tumors not considered metastasis, invasion, or recurrence of GIST, nor non-melanoma skin cancer. Data on gender, age at diagnosis, follow-up time after diagnosis, and death were collected.Results: Of the 783 patients with GIST, 153(20%) were identified with at least one additional primary. Patients with additional primaries were more often men (M : F 1.5 versus 1.3) and older (66 versus 53 years). More patients had another cancer diagnosed before (134) than after (52) GIST. Primaries observed before GIST were cancers of the prostate (25), breast (12), esophagus (9), and kidney (7) and melanoma (6). Lung (5) and kidney (5) primaries were the most frequent after GIST. The 5-year survival was 68% for patients with primaries before GIST, 61% for patients with primaries after GIST, 58% for patients with GIST only, and 49% for patients with two or more primaries in addition to GIST (P = 0.002).Conclusions: Approximately 20% of patients with GIST develop other cancers. Inferior median 5-year survival was observed in patients with GIST with two or more other cancers. The etiology and clinical implications of other malignancies in patients with GIST should be investigated.

Original languageEnglish
Pages (from-to)2107-2111
Number of pages5
JournalAnnals of Oncology
Volume21
Issue number10
DOIs
StatePublished - Mar 26 2010
Externally publishedYes

Fingerprint

Gastrointestinal Stromal Tumors
Survival
Neoplasms
Kidney
Skin Neoplasms
Esophagus

Keywords

  • GIST
  • Imatinib
  • Predisposition
  • Risk
  • Synchronous

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Pandurengan, R. K., Dumont, A. G., Araujo, D. M., Ludwig, J. A., Ravi, V., Patel, S., ... Trent, J. (2010). Survival of patients with multiple primary malignancies: A study of 783 patients with gastrointestinal stromal tumor. Annals of Oncology, 21(10), 2107-2111. https://doi.org/10.1093/annonc/mdq078

Survival of patients with multiple primary malignancies : A study of 783 patients with gastrointestinal stromal tumor. / Pandurengan, R. K.; Dumont, A. G.; Araujo, D. M.; Ludwig, J. A.; Ravi, V.; Patel, S.; Garber, J.; Benjamin, R. S.; Strom, S. S.; Trent, Jonathan.

In: Annals of Oncology, Vol. 21, No. 10, 26.03.2010, p. 2107-2111.

Research output: Contribution to journalArticle

Pandurengan, RK, Dumont, AG, Araujo, DM, Ludwig, JA, Ravi, V, Patel, S, Garber, J, Benjamin, RS, Strom, SS & Trent, J 2010, 'Survival of patients with multiple primary malignancies: A study of 783 patients with gastrointestinal stromal tumor', Annals of Oncology, vol. 21, no. 10, pp. 2107-2111. https://doi.org/10.1093/annonc/mdq078
Pandurengan, R. K. ; Dumont, A. G. ; Araujo, D. M. ; Ludwig, J. A. ; Ravi, V. ; Patel, S. ; Garber, J. ; Benjamin, R. S. ; Strom, S. S. ; Trent, Jonathan. / Survival of patients with multiple primary malignancies : A study of 783 patients with gastrointestinal stromal tumor. In: Annals of Oncology. 2010 ; Vol. 21, No. 10. pp. 2107-2111.
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AU - Araujo, D. M.

AU - Ludwig, J. A.

AU - Ravi, V.

AU - Patel, S.

AU - Garber, J.

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AU - Strom, S. S.

AU - Trent, Jonathan

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