Survival and disease progression in human immunodeficiency virus-infected women after an index delivery

D. J. Gloeb, S. Lai, J. Efantis, M. J. O'Sullivan

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objective: Our objective was to provide information on survival and disease progression in human immunodeficiency virus antibody-positive pregnant women undergoing prospective evaluation. Study design: After an index delivery, 103 human immunodeficiency virus antibody-positive pregnant women were identified and underwent follow-up for 3 years. The patients were assessed medically and/or gynecologically when hospitalized for a human immunodeficiency virus-related illness or at each follow-up visit. The life-table method was used to estimate the cumulative probabilities of survival and remaining free of acquired immunodeficiency syndrome. Cox's proportional-hazards analyses were used to identify prognostic factors for survival and progression to acquired immunodeficiency syndrome. Results: The majority of human immunodeficiency virus-infected pregnant women were alive 3 years later. Lymphadenopathy syndrome or herpes genitalis was significantly associated with a subsequent diagnosis of acquired immunodeficiency syndrome. Of the 103 original patients, six had acquired immunodeficiency syndrome at the index delivery and acquired immunodeficiency syndrome developed in 24. Approximately 94% of evaluable patients with development of acquired immunodeficiency syndrome had CD4-lymphocyte counts < 200/mm3. The most common opportunistic infection was Pneumocystis carinii pneumonia. Acquired immunodeficiency syndrome and postpartum zidovudine therapy were independent prognostic factors affecting survival. Conclusion: Survival was affected by Centers for Disease Control group status of human immunodeficiency virus infection at the index delivery.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume167
Issue number1
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • acquired immunodeficiency syndrome (AIDS) in pregnancy, survival of human immunodeficiency virus (HIV)-infected women
  • Cox's model
  • time-dependent covariates

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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