Surveillance cultures growing carbapenem-resistant acinetobacter baumannii predict the development of clinical infections: A retrospective cohort study

Rachel Latibeaudiere, Rossana Rosa, Panthipa Laowansiri, Kristopher Arheart, Nicholas Namias, Luisa Munoz-Price

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background. We aimed to determine the effect of the presence of carbapenem-resistant Acinetobacter baumannii in accordance with surveillance cultures on the subsequent development of clinical infections by this organism. Methods. This retrospective cohort study was conducted at a tertiary hospital from January 2010 to November 2011. We included all consecutive patients admitted to the trauma intensive care unit, who had weekly surveillance cultures performed (from rectum, and if intubated, respiratory secretions), and without evidence of A. baumannii infections prior to the collection of the first surveillance culture. Univariable and multivariable analyses were performed using log-binomial regression. Survival analyses were performed using Cox proportional hazards. Results. Three hundred sixty-four patients were included, of whom 49 (13.5%) had carbapenem-resistant A. baumannii on surveillance cultures. Patients with positive surveillance cultures had 8.4 (95% confidence interval [CI], 5.6-12.7; P <. 0001) times the risk of developing a subsequent A. baumannii infection compared with patients who remained negative on surveillance cultures. Multivariable analysis showed significant associations between clinical infection and both positive surveillance cultures (relative risk [RR], 5.9 [95% CI, 3.8-9.3]; P <. 0001) and mechanical ventilation (RR, 4.3 [95% CI, 1.03-18.2]; P =. 05). On survival analyses, the only variable associated with the development of clinical infections was the presence of positive surveillance cultures (hazard ratio, 16.3 [95% CI, 9.1-29.1]; P <. 001). Conclusions. Presence of carbapenem-resistant A. baumannii on surveillance cultures is strongly associated with subsequent development of carbapenem-resistant A. baumannii infections. Prevention efforts should be focused at limiting the acquisition of this organism during hospitalization.

Original languageEnglish
Pages (from-to)415-422
Number of pages8
JournalClinical Infectious Diseases
Volume60
Issue number3
DOIs
StatePublished - Feb 1 2015

Fingerprint

Acinetobacter baumannii
Carbapenems
Cohort Studies
Acinetobacter Infections
Retrospective Studies
Infection
Confidence Intervals
Survival Analysis
Artificial Respiration
Rectum
Tertiary Care Centers
Intensive Care Units
Hospitalization
Wounds and Injuries

Keywords

  • Acinetobacter baumannii
  • carbapenem-resistant
  • clinical infections
  • intensive care unit
  • surveillance cultures

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Surveillance cultures growing carbapenem-resistant acinetobacter baumannii predict the development of clinical infections : A retrospective cohort study. / Latibeaudiere, Rachel; Rosa, Rossana; Laowansiri, Panthipa; Arheart, Kristopher; Namias, Nicholas; Munoz-Price, Luisa.

In: Clinical Infectious Diseases, Vol. 60, No. 3, 01.02.2015, p. 415-422.

Research output: Contribution to journalArticle

Latibeaudiere, Rachel ; Rosa, Rossana ; Laowansiri, Panthipa ; Arheart, Kristopher ; Namias, Nicholas ; Munoz-Price, Luisa. / Surveillance cultures growing carbapenem-resistant acinetobacter baumannii predict the development of clinical infections : A retrospective cohort study. In: Clinical Infectious Diseases. 2015 ; Vol. 60, No. 3. pp. 415-422.
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abstract = "Background. We aimed to determine the effect of the presence of carbapenem-resistant Acinetobacter baumannii in accordance with surveillance cultures on the subsequent development of clinical infections by this organism. Methods. This retrospective cohort study was conducted at a tertiary hospital from January 2010 to November 2011. We included all consecutive patients admitted to the trauma intensive care unit, who had weekly surveillance cultures performed (from rectum, and if intubated, respiratory secretions), and without evidence of A. baumannii infections prior to the collection of the first surveillance culture. Univariable and multivariable analyses were performed using log-binomial regression. Survival analyses were performed using Cox proportional hazards. Results. Three hundred sixty-four patients were included, of whom 49 (13.5{\%}) had carbapenem-resistant A. baumannii on surveillance cultures. Patients with positive surveillance cultures had 8.4 (95{\%} confidence interval [CI], 5.6-12.7; P <. 0001) times the risk of developing a subsequent A. baumannii infection compared with patients who remained negative on surveillance cultures. Multivariable analysis showed significant associations between clinical infection and both positive surveillance cultures (relative risk [RR], 5.9 [95{\%} CI, 3.8-9.3]; P <. 0001) and mechanical ventilation (RR, 4.3 [95{\%} CI, 1.03-18.2]; P =. 05). On survival analyses, the only variable associated with the development of clinical infections was the presence of positive surveillance cultures (hazard ratio, 16.3 [95{\%} CI, 9.1-29.1]; P <. 001). Conclusions. Presence of carbapenem-resistant A. baumannii on surveillance cultures is strongly associated with subsequent development of carbapenem-resistant A. baumannii infections. Prevention efforts should be focused at limiting the acquisition of this organism during hospitalization.",
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AU - Latibeaudiere, Rachel

AU - Rosa, Rossana

AU - Laowansiri, Panthipa

AU - Arheart, Kristopher

AU - Namias, Nicholas

AU - Munoz-Price, Luisa

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AB - Background. We aimed to determine the effect of the presence of carbapenem-resistant Acinetobacter baumannii in accordance with surveillance cultures on the subsequent development of clinical infections by this organism. Methods. This retrospective cohort study was conducted at a tertiary hospital from January 2010 to November 2011. We included all consecutive patients admitted to the trauma intensive care unit, who had weekly surveillance cultures performed (from rectum, and if intubated, respiratory secretions), and without evidence of A. baumannii infections prior to the collection of the first surveillance culture. Univariable and multivariable analyses were performed using log-binomial regression. Survival analyses were performed using Cox proportional hazards. Results. Three hundred sixty-four patients were included, of whom 49 (13.5%) had carbapenem-resistant A. baumannii on surveillance cultures. Patients with positive surveillance cultures had 8.4 (95% confidence interval [CI], 5.6-12.7; P <. 0001) times the risk of developing a subsequent A. baumannii infection compared with patients who remained negative on surveillance cultures. Multivariable analysis showed significant associations between clinical infection and both positive surveillance cultures (relative risk [RR], 5.9 [95% CI, 3.8-9.3]; P <. 0001) and mechanical ventilation (RR, 4.3 [95% CI, 1.03-18.2]; P =. 05). On survival analyses, the only variable associated with the development of clinical infections was the presence of positive surveillance cultures (hazard ratio, 16.3 [95% CI, 9.1-29.1]; P <. 001). Conclusions. Presence of carbapenem-resistant A. baumannii on surveillance cultures is strongly associated with subsequent development of carbapenem-resistant A. baumannii infections. Prevention efforts should be focused at limiting the acquisition of this organism during hospitalization.

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KW - intensive care unit

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