Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis

Jeffrey T. Keating, Tan Ince, Christopher P. Crum

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The current prevention of cervical cancer and elimination of its precursors is predicated on the identification of cervical cytologic abnormalities and their histologic confirmation. This strategy, although effective, depends on both sensitivity and specificity of cytology and precise histologic distinction between precursor lesions and their mimics during biopsy interpretation. The effective application of diagnostic criteria is operator dependent and varies as a function of experience and training. However, because human papilloma viruses (HPV) are causative agents and alter the cell cycle in cervical neoplasms, host genes interacting directly or indirectly with HPV oncoproteins have been identified in vitro. Recent research has centered on identifying the host genes upregulated in association with HPV infection, determining their suitability as "surrogate markers" for HPV infection, and using these markers to identify HPV-associated epithelial lesions in tissue or cytologic specimens. This review surveys recent advances in this field, summarizing the advantages and limitations of several candidate biomarkers, including PCNA, Ki-67, cyclin E, p16ink4, MN antigen, carcinoembryonic antigen (CEA), and telomerase in the recognition of preinvasive cervical neoplasia, and discusses their future potential in cervical cancer screening. Based on current studies, the strongest candidates for diagnosis and screening are p16 and cyclin E (squamous) and MN (glandular) biomarkers. As new genes are identified and tested, the concept of biomarkers as tools in primary screening and lesion recognition will continue to mature.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalAdvances in Anatomic Pathology
Volume8
Issue number2
DOIs
StatePublished - Mar 1 2001
Externally publishedYes

Fingerprint

Papillomaviridae
Virus Diseases
Biomarkers
Uterine Cervical Neoplasms
Cyclin E
Neoplasms
Neoplasm Genes
Telomerase
Oncogene Proteins
Carcinoembryonic Antigen
Proliferating Cell Nuclear Antigen
Early Detection of Cancer
Genes
Cell Biology
Cell Cycle
Biopsy
Antigens
Sensitivity and Specificity
Research

Keywords

  • Cervix
  • Cervix neoplasia
  • Cyclin E-MN antigen
  • Human papilloma virus (HPV)
  • p16

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

Cite this

Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis. / Keating, Jeffrey T.; Ince, Tan; Crum, Christopher P.

In: Advances in Anatomic Pathology, Vol. 8, No. 2, 01.03.2001, p. 83-92.

Research output: Contribution to journalArticle

Keating, Jeffrey T. ; Ince, Tan ; Crum, Christopher P. / Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis. In: Advances in Anatomic Pathology. 2001 ; Vol. 8, No. 2. pp. 83-92.
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