Surgical therapy of end-stage heart failure: Understanding cell-mediated mechanisms interacting with myocardial damage

Ali Ghodsizad, Mathias Loebe, Christoph Piechaczek, Viktor Bordel, Matthias N. Ungerer, Igor Gregoric, Brian Bruckner, George P. Noon, Matthias Karck, Arjang Ruhparwar

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Worldwide, cardiovascular disease results in an estimated 14.3 million deaths per year, giving rise to an increased demand for alternative and advanced treatment. Current approaches include medical management, cardiac transplantation, device therapy, and, most recently, stem cell therapy. Research into cell-based therapies has shown this option to be a promising alternative to the conventional methods. In contrast to early trials, modern approaches now attempt to isolate specifc stem cells, as well as increase their numbers by means of amplifying in a culture environment. The method of delivery has also been improved to minimize the risk of micro-infarcts and embolization, which were often observed after the use of coronary catheterization. The latest approach entails direct, surgical, trans-epicardial injection of the stem cell mixture, as well as the use of tissue-engineered meshes consisting of embedded progenitor cells.

Original languageEnglish (US)
Pages (from-to)529-545
Number of pages17
JournalInternational Journal of Artificial Organs
Volume34
Issue number7
DOIs
StatePublished - Jul 1 2011

Keywords

  • Heart failure
  • Left ventricular assist device (LVAD) implantation
  • Myocardial recovery
  • Regenerative therapy
  • Stem cell therapy

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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    Ghodsizad, A., Loebe, M., Piechaczek, C., Bordel, V., Ungerer, M. N., Gregoric, I., Bruckner, B., Noon, G. P., Karck, M., & Ruhparwar, A. (2011). Surgical therapy of end-stage heart failure: Understanding cell-mediated mechanisms interacting with myocardial damage. International Journal of Artificial Organs, 34(7), 529-545. https://doi.org/10.5301/ijao.5000004