Surgical neurostimulation for spinal cord injury

Aswin Chari, Ian Hentall, Marios C. Papadopoulos, Erlick A C Pereira

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI.We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI.

Original languageEnglish (US)
Article number18
JournalBrain Sciences
Volume7
Issue number2
DOIs
StatePublished - Feb 10 2017

Fingerprint

Spinal Cord Injuries
Spinal Cord Stimulation
Aptitude
Therapeutics
Pain
Deep Brain Stimulation
Neurobiology
Transcranial Magnetic Stimulation
Paresthesia
Motor Cortex
Resuscitation
Paralysis
Spinal Cord
Urinary Bladder
Rehabilitation

Keywords

  • Deep brain stimulation
  • Neuromodulation
  • Spinal cord injury
  • Spinal cord stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chari, A., Hentall, I., Papadopoulos, M. C., & Pereira, E. A. C. (2017). Surgical neurostimulation for spinal cord injury. Brain Sciences, 7(2), [18]. https://doi.org/10.3390/brainsci7020018

Surgical neurostimulation for spinal cord injury. / Chari, Aswin; Hentall, Ian; Papadopoulos, Marios C.; Pereira, Erlick A C.

In: Brain Sciences, Vol. 7, No. 2, 18, 10.02.2017.

Research output: Contribution to journalReview article

Chari, A, Hentall, I, Papadopoulos, MC & Pereira, EAC 2017, 'Surgical neurostimulation for spinal cord injury', Brain Sciences, vol. 7, no. 2, 18. https://doi.org/10.3390/brainsci7020018
Chari A, Hentall I, Papadopoulos MC, Pereira EAC. Surgical neurostimulation for spinal cord injury. Brain Sciences. 2017 Feb 10;7(2). 18. https://doi.org/10.3390/brainsci7020018
Chari, Aswin ; Hentall, Ian ; Papadopoulos, Marios C. ; Pereira, Erlick A C. / Surgical neurostimulation for spinal cord injury. In: Brain Sciences. 2017 ; Vol. 7, No. 2.
@article{779c01608ca44814a0c39bc39bfb1a0b,
title = "Surgical neurostimulation for spinal cord injury",
abstract = "Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI.We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI.",
keywords = "Deep brain stimulation, Neuromodulation, Spinal cord injury, Spinal cord stimulation",
author = "Aswin Chari and Ian Hentall and Papadopoulos, {Marios C.} and Pereira, {Erlick A C}",
year = "2017",
month = "2",
day = "10",
doi = "10.3390/brainsci7020018",
language = "English (US)",
volume = "7",
journal = "Brain Sciences",
issn = "2076-3425",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

TY - JOUR

T1 - Surgical neurostimulation for spinal cord injury

AU - Chari, Aswin

AU - Hentall, Ian

AU - Papadopoulos, Marios C.

AU - Pereira, Erlick A C

PY - 2017/2/10

Y1 - 2017/2/10

N2 - Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI.We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI.

AB - Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI.We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI.

KW - Deep brain stimulation

KW - Neuromodulation

KW - Spinal cord injury

KW - Spinal cord stimulation

UR - http://www.scopus.com/inward/record.url?scp=85012278132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012278132&partnerID=8YFLogxK

U2 - 10.3390/brainsci7020018

DO - 10.3390/brainsci7020018

M3 - Review article

AN - SCOPUS:85012278132

VL - 7

JO - Brain Sciences

JF - Brain Sciences

SN - 2076-3425

IS - 2

M1 - 18

ER -