Surgical management of posterior uveal melanoma: Trends and developments

Samuel K. Houston, Marcela Ardila-Lonngi, Arnold Markoe, Timothy G. Murray

Research output: Contribution to journalArticle

Abstract

Uveal melanoma is the most common primary malignancy of the eye in adults and affects approximately four people per million in the USA each year. Historically, patients were treated with enucleation, but results of the Collaborative Ocular Melanoma Study paved the way for globe-salvaging treatment. With plaque brachytherapy and proton beam irradiation having similar outcomes as enucleation in medium tumors, a new set of problems surfaced. Radiation-related complications caused severe visual morbidity in the majority of patients, with some progressing to neovascular glaucoma and requiring enucleation. To combat these issues, varying surgical managements have emerged as primary treatments for uveal melanomas as well as to treat radiation-related complications. We anticipate further advancements and studies regarding these surgical techniques, as well as a better understanding of the gene expression profiling of these tumors and their propensity for metastasis.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalExpert Review of Ophthalmology
Volume8
Issue number4
DOIs
StatePublished - Aug 1 2013

Keywords

  • brachytherapy
  • endoresection
  • enucleation
  • ocular oncology
  • radiation retinopathy
  • sclerouvectomy
  • uveal melanoma
  • vitrectomy

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology
  • Optometry

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