Surfactant treatment and ventilation by high frequency oscillation in premature newborn rabbits: Effect on survival, lung aeration, and bronchiolar epithelial lesions

Roland Nilsson, Per Berggren, Tore Curstedt, Gertie Grossmann, Gunnar Renheim, Bengt Robertson

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Premature rabbit neonates delivered at gestational age 27 days were ventilated by high frequency oscillation for 60 min with 100% O2, using a frequency of 7-8 Hz, 50% inspiration time and mean airway pressures of 6-8 cm H2O. Twenty-five animals received bovine surfactant (2 ml/kg body weight; phospholipid concentration 85-100 mg/ml) in the tracheal cannula before onset of ventilation, and 22 littermates served as controls. In the surfactant-treated group, average tidal volume was about 10 times larger than in controls, yet only 15% of the estimated dead space. Judged from ECG recordings, the treated animals also had a much higher survival rate: 96 versus 5% (p < 0.001). Morphometrically, mean alveolar volume density was increased in the surfactant-treated animals in comparison with controls: 0.65 ± 0.08 versus 0.37 ± 0.08 (x̄ ± SD; p < 0.005). Bronchiolar epithelial lesions were found in all control animals and were severe in almost all cases. In the surfactant-treated group, epithelial lesions were absent in 12, mild in 11, and fairly prominent in 2 animals. We conclude that after treatment with surfactant, the premature newborn rabbit can be ventilated adequately with high frequency oscillation at comparatively low mean airway pressures and that surfactant replacement effectively reduces the development of epithelial lesions in conducting airways during high frequency oscillation.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalPediatric Research
Volume19
Issue number1
DOIs
StatePublished - Jan 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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