The purpose of this study was to evaluate the effect of surfactant replacement in experimental adult respiratory-distress syndrome (RDS). Severe RDS, characterized by marked hypoxia and hypercapnia, was induced in artificially ventilated guinea pigs by repeated lung lavage. In experimental animals, 1 ml of natural surfactant (phospholipid concentration 90 mg/ml) was instilled via the tracheal cannula immediately after lung lavage, and another identical dose was given 30 min later. Blood gases were determined every 15 min for 1 hour. In treated animals, PaO2 and PaCO2 values were restored to pre-lavage levels usually after the first surfactant deposition, whereas control animals remained hypoxic and hypercapnic. The lungs of control animals revealed wide-spread alveolar collapse and abundant bronchiolar epithelial lesions. Surfactant-treated animals showed uniform alveolar air expansion and only minor epithelial lesions. Surfactant treatment thus offers effective protection against both functional disturbances and morphologic lesions in this model of adult RDS.
|Original language||English (US)|
|Number of pages||2|
|Journal||IRCS Medical Science|
|State||Published - Jan 1 1983|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)