Surface treatments of polymers for biocompatibility

Donald L. Elbert, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

442 Citations (Scopus)

Abstract

Biological recognition mediates cell and tissue interactions with biomaterials, be the materials employed in a biotechnical environment in vitro or a biomedical environment in vivo. These interactions are typically mediated by proteins that have adsorbed to the biomaterial surface. The principles of protein adsorption and biological recognition are described. Polymer surface modifications to reduce protein adsorption upon biomaterial surfaces are summarized, as are modifications to enhance the irreversible adsorption of proteins. Using these approaches, it may be possible to reduce the extent to which the biomaterial surface and the proteinbiomaterial surface are recognized by cells and tissues. Polymer surface modifications to incorporate oligopeptide-, saccharide-, and oligosaccharide-based receptor-binding sequences are described to enable direct binding of cells with the polymer surface. With use of these approaches, it is possible to endow an entirely synthetic material with the biological recognition characteristics of biological macromolecules.

Original languageEnglish
Pages (from-to)365-394
Number of pages30
JournalAnnual Review of Materials Science
Volume26
Issue number1
StatePublished - Dec 1 1996
Externally publishedYes

Fingerprint

Biocompatibility
Surface treatment
Biocompatible Materials
Polymers
Biomaterials
Proteins
Adsorption
Tissue
Oligosaccharides
Oligopeptides
Macromolecules

Keywords

  • Biomaterial
  • Hydrogel
  • Peptide
  • Poly(ethylene glycol)
  • Saccharide

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Elbert, D. L., & Hubbell, J. A. (1996). Surface treatments of polymers for biocompatibility. Annual Review of Materials Science, 26(1), 365-394.

Surface treatments of polymers for biocompatibility. / Elbert, Donald L.; Hubbell, Jeffrey A.

In: Annual Review of Materials Science, Vol. 26, No. 1, 01.12.1996, p. 365-394.

Research output: Contribution to journalArticle

Elbert, DL & Hubbell, JA 1996, 'Surface treatments of polymers for biocompatibility', Annual Review of Materials Science, vol. 26, no. 1, pp. 365-394.
Elbert, Donald L. ; Hubbell, Jeffrey A. / Surface treatments of polymers for biocompatibility. In: Annual Review of Materials Science. 1996 ; Vol. 26, No. 1. pp. 365-394.
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