Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin

Cherie L. Stabler, Xue Long Sun, Wanxing Cui, John T. Wilson, Carolyn A. Haller, Elliot L. Chaikof

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses.

Original languageEnglish (US)
Pages (from-to)1713-1715
Number of pages3
JournalBioconjugate Chemistry
Volume18
Issue number6
DOIs
StatePublished - Nov 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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