Abstract
Purpose. To assess intracorneal biocolonization of expanded polytetrafluoroethylene (e-PTFE) materials covalently coated with collagen type-I. Methods. Two e-PTFE membrane types: M-10 (5-30 μm pores, 130 μm thickness, 75% porosity) and Z-30 (30-60 μm pores, 130 μm thickness, 94% porosity) were modified on one side by the covalent attachment of an ultrathin collagen coating. Coated and non-coated disks were inserted in the same right eye cornea of 12 pigmented rabbits, as well as a third e-PTFE type used as a control: 1-80 (40-60 μm pores, 260 μm thickness, 85% porosity). The coated surface of the disks was always facing the anterior side of the cornea. Enucleation was done at 7, 14 days, 1, 3 and 6 months for histology. Results. Both acute and chronic inflammatory response was more pronounced with the collagen coated materials, with neovascularization coming from the limbus towards the membranes anteriorly and a higher density of fibroblastic cells.
Original language | English (US) |
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Pages (from-to) | 130-133 |
Number of pages | 4 |
Journal | Proceedings of SPIE - The International Society for Optical Engineering |
Volume | 2971 |
DOIs | |
State | Published - Dec 1 1997 |
Event | Ophthalmic Technologies VII - San Jose, CA, United States Duration: Feb 8 1997 → Feb 8 1997 |
Keywords
- Biocolonization
- Collagen
- Cornea
- Gas plasma
- Keratoprosthesis
- Neovascularization
- Porous polytetrafluoroethylene
- Rabbit
- Surface modification
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering