Surface-modified porous PTFE for keratoprostheses: Biocolonization in the rabbit cornea

Sandrine Gautier; Bernard Duchesne; Hassan Tahi; Robert Rosa; Jean-Marie A Parel; Emmanuel Lacombe; Gerrit Beumer; Hans J. Griesser

doi:10.1117/12.275104

Surface-modified porous PTFE for keratoprostheses: Biocolonization in the rabbit cornea

Sandrine Gautier, Bernard Duchesne, Hassan Tahi, Robert Rosa, Jean-Marie A Parel, Emmanuel Lacombe, Gerrit Beumer, Hans J. Griesser

Ophthalmology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Purpose. To assess intracorneal biocolonization of expanded polytetrafluoroethylene (e-PTFE) materials covalently coated with collagen type-I. Methods. Two e-PTFE membrane types: M-10 (5-30 μm pores, 130 μm thickness, 75% porosity) and Z-30 (30-60 μm pores, 130 μm thickness, 94% porosity) were modified on one side by the covalent attachment of an ultrathin collagen coating. Coated and non-coated disks were inserted in the same right eye cornea of 12 pigmented rabbits, as well as a third e-PTFE type used as a control: 1-80 (40-60 μm pores, 260 μm thickness, 85% porosity). The coated surface of the disks was always facing the anterior side of the cornea. Enucleation was done at 7, 14 days, 1, 3 and 6 months for histology. Results. Both acute and chronic inflammatory response was more pronounced with the collagen coated materials, with neovascularization coming from the limbus towards the membranes anteriorly and a higher density of fibroblastic cells.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Pages	130-133
Number of pages	4
Volume	2971
DOIs	https://doi.org/10.1117/12.275104
State	Published - 1997
Event	Ophthalmic Technologies VII - San Jose, CA, United States Duration: Feb 8 1997 → Feb 8 1997

Other

Other	Ophthalmic Technologies VII
Country	United States
City	San Jose, CA
Period	2/8/97 → 2/8/97

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Keywords

Biocolonization
Collagen
Cornea
Gas plasma
Keratoprosthesis
Neovascularization
Porous polytetrafluoroethylene
Rabbit
Surface modification

ASJC Scopus subject areas

Applied Mathematics
Computer Science Applications
Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials
Condensed Matter Physics

Cite this

Gautier, S., Duchesne, B., Tahi, H., Rosa, R., Parel, J-M. A., Lacombe, E., Beumer, G., & Griesser, H. J. (1997). Surface-modified porous PTFE for keratoprostheses: Biocolonization in the rabbit cornea. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2971, pp. 130-133) https://doi.org/10.1117/12.275104

Surface-modified porous PTFE for keratoprostheses : Biocolonization in the rabbit cornea. / Gautier, Sandrine; Duchesne, Bernard; Tahi, Hassan; Rosa, Robert; Parel, Jean-Marie A; Lacombe, Emmanuel; Beumer, Gerrit; Griesser, Hans J.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2971 1997. p. 130-133.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gautier, S, Duchesne, B, Tahi, H, Rosa, R, Parel, J-MA, Lacombe, E, Beumer, G & Griesser, HJ 1997, Surface-modified porous PTFE for keratoprostheses: Biocolonization in the rabbit cornea. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 2971, pp. 130-133, Ophthalmic Technologies VII, San Jose, CA, United States, 2/8/97. https://doi.org/10.1117/12.275104

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Access to Document

10.1117/12.275104