Surface-modified porous PTFE for keratoprostheses: Biocolonization in the rabbit cornea

Sandrine Gautier, Bernard Duchesne, Hassan Tahi, Robert Rosa, Jean Marie A. Parel, Emmanuel Lacombe, Gerrit Beumer, Hans J. Griesser

Research output: Contribution to journalConference article

Abstract

Purpose. To assess intracorneal biocolonization of expanded polytetrafluoroethylene (e-PTFE) materials covalently coated with collagen type-I. Methods. Two e-PTFE membrane types: M-10 (5-30 μm pores, 130 μm thickness, 75% porosity) and Z-30 (30-60 μm pores, 130 μm thickness, 94% porosity) were modified on one side by the covalent attachment of an ultrathin collagen coating. Coated and non-coated disks were inserted in the same right eye cornea of 12 pigmented rabbits, as well as a third e-PTFE type used as a control: 1-80 (40-60 μm pores, 260 μm thickness, 85% porosity). The coated surface of the disks was always facing the anterior side of the cornea. Enucleation was done at 7, 14 days, 1, 3 and 6 months for histology. Results. Both acute and chronic inflammatory response was more pronounced with the collagen coated materials, with neovascularization coming from the limbus towards the membranes anteriorly and a higher density of fibroblastic cells.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume2971
DOIs
StatePublished - Dec 1 1997
EventOphthalmic Technologies VII - San Jose, CA, United States
Duration: Feb 8 1997Feb 8 1997

Keywords

  • Biocolonization
  • Collagen
  • Cornea
  • Gas plasma
  • Keratoprosthesis
  • Neovascularization
  • Porous polytetrafluoroethylene
  • Rabbit
  • Surface modification

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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