Surface modifications of polymeric biomaterials for reduced thrombogenicity

Neil P. Desai, Jeffrey A. Hubbell

Research output: Contribution to journalConference article

15 Scopus citations

Abstract

Currently used biomedical polymers in applications involving blood contact have not proved to be sufficiently nonthrombogenic to be useful in small diameter vascular grafts. It has been observed that polyethylene oxide (PEO) surfaces resist adsorption of plasma proteins as a result of their strong hydrophilicity and chain mobility. Hence the covalent grafting of PEO onto the surfaces of extensively used biomedical polymers such as polyethylene terephthalate (PET) and polytetrafluoroethylene (PTFE) could serve to reduce the interaction of blood components with these surfaces while still retaining the integrity of the bulk polymer.

Original languageEnglish (US)
Pages (from-to)731-735
Number of pages5
JournalPolymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
Volume62
StatePublished - Jan 1 1990
EventProceedings of the ACS Division of Polymeric Materials: Science and Engineering - Boston, MA, USA
Duration: Apr 1 1990Apr 1 1990

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Polymers and Plastics
  • Engineering(all)

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