Surface modifications of polymeric biomaterials for reduced thrombogenicity

Neil P. Desai, Jeffrey A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

15 Citations (Scopus)

Abstract

Currently used biomedical polymers in applications involving blood contact have not proved to be sufficiently nonthrombogenic to be useful in small diameter vascular grafts. It has been observed that polyethylene oxide (PEO) surfaces resist adsorption of plasma proteins as a result of their strong hydrophilicity and chain mobility. Hence the covalent grafting of PEO onto the surfaces of extensively used biomedical polymers such as polyethylene terephthalate (PET) and polytetrafluoroethylene (PTFE) could serve to reduce the interaction of blood components with these surfaces while still retaining the integrity of the bulk polymer.

Original languageEnglish (US)
Title of host publicationPolymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
PublisherPubl by ACS
Pages731-735
Number of pages5
Volume62
StatePublished - 1990
Externally publishedYes
EventProceedings of the ACS Division of Polymeric Materials: Science and Engineering - Boston, MA, USA
Duration: Apr 1 1990Apr 1 1990

Other

OtherProceedings of the ACS Division of Polymeric Materials: Science and Engineering
CityBoston, MA, USA
Period4/1/904/1/90

Fingerprint

Biocompatible Materials
Biomaterials
Surface treatment
Polymers
Polyethylene oxides
Blood
Polyethylene Terephthalates
Hydrophilicity
Polytetrafluoroethylene
Polytetrafluoroethylenes
Grafts
Polyethylene terephthalates
Blood Proteins
Proteins
Plasmas
Adsorption

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Polymers and Plastics
  • Engineering(all)

Cite this

Desai, N. P., & Hubbell, J. A. (1990). Surface modifications of polymeric biomaterials for reduced thrombogenicity. In Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering (Vol. 62, pp. 731-735). Publ by ACS.

Surface modifications of polymeric biomaterials for reduced thrombogenicity. / Desai, Neil P.; Hubbell, Jeffrey A.

Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Vol. 62 Publ by ACS, 1990. p. 731-735.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Desai, NP & Hubbell, JA 1990, Surface modifications of polymeric biomaterials for reduced thrombogenicity. in Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. vol. 62, Publ by ACS, pp. 731-735, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, Boston, MA, USA, 4/1/90.
Desai NP, Hubbell JA. Surface modifications of polymeric biomaterials for reduced thrombogenicity. In Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Vol. 62. Publ by ACS. 1990. p. 731-735
Desai, Neil P. ; Hubbell, Jeffrey A. / Surface modifications of polymeric biomaterials for reduced thrombogenicity. Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Vol. 62 Publ by ACS, 1990. pp. 731-735
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