Supraselective injection of intraarterial melphalan as the primary treatment for late presentation unilateral multifocal stage VB retinoblastoma

Hassan A. Aziz, Hinda Boutrid, Timothy G. Murray, Audina Berrocal, Stacey Quintero Wolfe, Yolanda Pina, Mark Dorfman, Roham Moftakhar, Cristina E. Fernandes, Jennifer Reichbach, Mohammad Ali Aziz-Sultan

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20 Scopus citations

Abstract

Purpose: The purpose of this study was to report a case of a 7-year-old girl with unilateral, multifocal Reese Ellsworth Stage Vb retinoblastoma who was successfully treated using intraarterial chemotherapy infusion as the primary therapy. Methods: This is an interventional case report. A 7-year-old girl presented with advanced unilateral retinoblastoma. The patient received intraarterial melphalan infusion therapy as the primary treatment. Results: Complete tumor resolution was seen at 1 month after intraarterial melphalan infusion. Conclusion: This case of advanced retinoblastoma in a 7-year-old girl was successfully treated with intraarterial melphalan infusion alone. Treatment resulted in complete resolution of the tumor 1 month after treatment. In comparison with systemic chemotherapy, intraarterial melphalan infusion therapy may be a less toxic and more effective primary treatment option in the future management of advanced retinoblastoma.

Original languageEnglish (US)
Pages (from-to)S63-S65
JournalRetina
Volume30
Issue number4 SUPPL. 4
DOIs
StatePublished - Apr 1 2010

Keywords

  • Intraarterial chemotherapy
  • Melphalan
  • Retinoblastoma

ASJC Scopus subject areas

  • Ophthalmology

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    Aziz, H. A., Boutrid, H., Murray, T. G., Berrocal, A., Wolfe, S. Q., Pina, Y., Dorfman, M., Moftakhar, R., Fernandes, C. E., Reichbach, J., & Aziz-Sultan, M. A. (2010). Supraselective injection of intraarterial melphalan as the primary treatment for late presentation unilateral multifocal stage VB retinoblastoma. Retina, 30(4 SUPPL. 4), S63-S65. https://doi.org/10.1097/IAE.0b013e3181cbda0f