Suppressor cells in common variable hypogammaglobulinemia with SRBC receptors and surface immunoglobulin

R. S. Krakauer, J. D. Clough, J. T. Sundeen, D. N. Sauder, R. Valenzuela, R. Savage

Research output: Contribution to journalArticle

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Abstract

Common variable hypogammaglobulinemia (CVH) or adult-onset agammaglobulinemia is an acquired humoral immune deficiency characterized by low levels of circulating IgG, IgA, and usually IgM, frequent sinopulmonary infections and commonly, gastrointestinal tract infections. Although its place in the pathogenesis of this disease is unclear, a portion of patients with CVH have circulating suppressor T-lymphocytes capable of inhibiting immunoglobulin synthesis by B-lymphocytes of both the patient himself and normals with no humoral immune deficiency. In at least some situations, B-lymphocytes from such patients are capable of immunoglobulin synthesis when removed from the suppressor influences of their own T-cells. Although in mice surface antigens have been identified which are in varying degrees specific for suppressor cells, such cells have not yet been separated in humans. Although human T-lymphocytes with IgM Fc receptors have been characterized as helpers, while those with IgG Fc receptors as suppressors, there are experimental circumstances in which this division breaks down. We here describe a patient with common variable hypogammaglobulinemia with circulating suppressor cells whose unique surface characteristics enabled their physical separation.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalImmunology Letters
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

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Common Variable Immunodeficiency
B-Cell Antigen Receptors
T-Lymphocytes
B-Lymphocytes
IgG Receptors
Agammaglobulinemia
Fc Receptors
Surface Antigens
Infection
Immunoglobulin A
Immunoglobulin M
Gastrointestinal Tract
Immunoglobulins
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Krakauer, R. S., Clough, J. D., Sundeen, J. T., Sauder, D. N., Valenzuela, R., & Savage, R. (1979). Suppressor cells in common variable hypogammaglobulinemia with SRBC receptors and surface immunoglobulin. Immunology Letters, 1(3), 161-164. https://doi.org/10.1016/0165-2478(79)90022-1

Suppressor cells in common variable hypogammaglobulinemia with SRBC receptors and surface immunoglobulin. / Krakauer, R. S.; Clough, J. D.; Sundeen, J. T.; Sauder, D. N.; Valenzuela, R.; Savage, R.

In: Immunology Letters, Vol. 1, No. 3, 01.01.1979, p. 161-164.

Research output: Contribution to journalArticle

Krakauer, RS, Clough, JD, Sundeen, JT, Sauder, DN, Valenzuela, R & Savage, R 1979, 'Suppressor cells in common variable hypogammaglobulinemia with SRBC receptors and surface immunoglobulin', Immunology Letters, vol. 1, no. 3, pp. 161-164. https://doi.org/10.1016/0165-2478(79)90022-1
Krakauer, R. S. ; Clough, J. D. ; Sundeen, J. T. ; Sauder, D. N. ; Valenzuela, R. ; Savage, R. / Suppressor cells in common variable hypogammaglobulinemia with SRBC receptors and surface immunoglobulin. In: Immunology Letters. 1979 ; Vol. 1, No. 3. pp. 161-164.
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