Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

E. S. Canales, H. Montvelinsky, A. Zarate, A. J. Kastin, D. H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

Original languageEnglish
Pages (from-to)190-192
Number of pages3
JournalInternational Journal of Fertility
Volume25
Issue number3
StatePublished - Dec 1 1980
Externally publishedYes

Fingerprint

Gonadotropins
Gonadotropin-Releasing Hormone
Menstrual Cycle
Ovulation
Estradiol
Injections

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women. / Canales, E. S.; Montvelinsky, H.; Zarate, A.; Kastin, A. J.; Coy, D. H.; Schally, Andrew V.

In: International Journal of Fertility, Vol. 25, No. 3, 01.12.1980, p. 190-192.

Research output: Contribution to journalArticle

Canales, ES, Montvelinsky, H, Zarate, A, Kastin, AJ, Coy, DH & Schally, AV 1980, 'Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women', International Journal of Fertility, vol. 25, no. 3, pp. 190-192.
Canales, E. S. ; Montvelinsky, H. ; Zarate, A. ; Kastin, A. J. ; Coy, D. H. ; Schally, Andrew V. / Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women. In: International Journal of Fertility. 1980 ; Vol. 25, No. 3. pp. 190-192.
@article{9198a1e7768d407a94164203f349e456,
title = "Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women",
abstract = "Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.",
author = "Canales, {E. S.} and H. Montvelinsky and A. Zarate and Kastin, {A. J.} and Coy, {D. H.} and Schally, {Andrew V}",
year = "1980",
month = "12",
day = "1",
language = "English",
volume = "25",
pages = "190--192",
journal = "International Journal of Fertility",
issn = "0020-725X",
publisher = "MSP International",
number = "3",

}

TY - JOUR

T1 - Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

AU - Canales, E. S.

AU - Montvelinsky, H.

AU - Zarate, A.

AU - Kastin, A. J.

AU - Coy, D. H.

AU - Schally, Andrew V

PY - 1980/12/1

Y1 - 1980/12/1

N2 - Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

AB - Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

UR - http://www.scopus.com/inward/record.url?scp=0019122659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019122659&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 190

EP - 192

JO - International Journal of Fertility

JF - International Journal of Fertility

SN - 0020-725X

IS - 3

ER -