Abstract
Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 190-192 |
| Number of pages | 3 |
| Journal | International Journal of Fertility |
| Volume | 25 |
| Issue number | 3 |
| State | Published - Dec 1 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Canales, E. S., Montvelinsky, H., Zarate, A., Kastin, A. J., Coy, D. H., & Schally, A. V. (1980). Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women. International Journal of Fertility, 25(3), 190-192.