Abstract
Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.
| Original language | English |
|---|---|
| Pages (from-to) | 190-192 |
| Number of pages | 3 |
| Journal | International Journal of Fertility |
| Volume | 25 |
| Issue number | 3 |
| State | Published - Dec 1 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women. / Canales, E. S.; Montvelinsky, H.; Zarate, A.; Kastin, A. J.; Coy, D. H.; Schally, Andrew V.
In: International Journal of Fertility, Vol. 25, No. 3, 01.12.1980, p. 190-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women
AU - Canales, E. S.
AU - Montvelinsky, H.
AU - Zarate, A.
AU - Kastin, A. J.
AU - Coy, D. H.
AU - Schally, Andrew V
PY - 1980/12/1
Y1 - 1980/12/1
N2 - Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.
AB - Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.
UR - http://www.scopus.com/inward/record.url?scp=0019122659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019122659&partnerID=8YFLogxK
M3 - Article
VL - 25
SP - 190
EP - 192
JO - International Journal of Fertility
JF - International Journal of Fertility
SN - 0020-725X
IS - 3
ER -