Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

E. S. Canales; H. Montvelinsky; A. Zarate; A. J. Kastin; D. H. Coy; A. V. Schally

Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

E. S. Canales, H. Montvelinsky, A. Zarate, A. J. Kastin, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

Abstract

Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

Original language	English (US)
Pages (from-to)	190-192
Number of pages	3
Journal	International Journal of Fertility
Volume	25
Issue number	3
State	Published - Dec 1 1980
Externally published	Yes

ASJC Scopus subject areas

Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women'. Together they form a unique fingerprint.

Cite this

@article{9198a1e7768d407a94164203f349e456,

title = "Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women",

abstract = "Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.",

author = "Canales, {E. S.} and H. Montvelinsky and A. Zarate and Kastin, {A. J.} and Coy, {D. H.} and Schally, {A. V.}",

year = "1980",

month = dec,

day = "1",

language = "English (US)",

volume = "25",

pages = "190--192",

journal = "International Journal of Fertility",

issn = "0020-725X",

publisher = "MSP International",

number = "3",

}

TY - JOUR

T1 - Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

AU - Canales, E. S.

AU - Montvelinsky, H.

AU - Zarate, A.

AU - Kastin, A. J.

AU - Coy, D. H.

AU - Schally, A. V.

PY - 1980/12/1

Y1 - 1980/12/1

N2 - Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

AB - Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

UR - http://www.scopus.com/inward/record.url?scp=0019122659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019122659&partnerID=8YFLogxK

M3 - Article

C2 - 6108928

AN - SCOPUS:0019122659

VL - 25

SP - 190

EP - 192

JO - International Journal of Fertility

JF - International Journal of Fertility

SN - 0020-725X

IS - 3

ER -

Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

Abstract

ASJC Scopus subject areas

Other files and links

Cite this