Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

E. S. Canales; H. Montvelinsky; A. Zarate; A. J. Kastin; D. H. Coy; A. V. Schally

Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

E. S. Canales, H. Montvelinsky, A. Zarate, A. J. Kastin, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

Abstract

Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

Original language	English (US)
Pages (from-to)	190-192
Number of pages	3
Journal	International Journal of Fertility
Volume	25
Issue number	3
State	Published - Dec 1 1980
Externally published	Yes

ASJC Scopus subject areas

Obstetrics and Gynecology

Cite this

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title = "Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women",

abstract = "Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.",

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language = "English (US)",

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AU - Canales, E. S.

AU - Montvelinsky, H.

AU - Zarate, A.

AU - Kastin, A. J.

AU - Coy, D. H.

AU - Schally, A. V.

PY - 1980/12/1

Y1 - 1980/12/1

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AB - Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

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ER -

Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

Abstract

ASJC Scopus subject areas

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