Suppressive effect of an inhibitory LHRH analog on the gonadotropin response to LHRH in normal women

E. S. Canales, H. Montvelinsky, A. Zarate, A. J. Kastin, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticle

17 Scopus citations


Intramuscular administration of 90 mg of D-Phe-2, D-Trp-3, D-Phe-6-LHRH, an inhibitory analog of LHRH, to eight normal women diminished the gonadotropin response to 50 μg of LHRH administered 3 and 6 hours later; however, an additional dose of LHRH 24 hours after the injection of the inhibitory analog elicited a significant secretion of both LH and FSH which in turn produced a significant release of estradiol. The menstrual cycle was disrupted in all eight cases and ovulation did not occur.

Original languageEnglish (US)
Pages (from-to)190-192
Number of pages3
JournalInternational Journal of Fertility
Issue number3
StatePublished - Dec 1 1980
Externally publishedYes


ASJC Scopus subject areas

  • Obstetrics and Gynecology

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