Suppression of somatostatin levels in the hepatic portal and systemic plasma of the rat by synthetic human pancreatic polypeptide

A. Arimura, C. A. Meyers, W. L. Case, W. A. Murphy, A. V. Schally

Research output: Contribution to journalArticle

18 Scopus citations


Intravenous administration of synthetic human pancreatic polypeptide (hPP) with 36 amino acid residues significantly decreased immunoreactive somatostatin levels in both hepatic portal and systemic plasma in anesthetized rats. The effect of hPP on plasma somatostatin levels is acute. The results suggest that hPP may have a role in controlling somatostatin secretion from the gut and pancreas.

Original languageEnglish (US)
Pages (from-to)913-918
Number of pages6
JournalBiochemical and biophysical research communications
Issue number3
StatePublished - Aug 13 1979


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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