Suppression of somatostatin levels in the hepatic portal and systemic plasma of the rat by synthetic human pancreatic polypeptide

A. Arimura, C. A. Meyers, W. L. Case, W. A. Murphy, Andrew V Schally

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Intravenous administration of synthetic human pancreatic polypeptide (hPP) with 36 amino acid residues significantly decreased immunoreactive somatostatin levels in both hepatic portal and systemic plasma in anesthetized rats. The effect of hPP on plasma somatostatin levels is acute. The results suggest that hPP may have a role in controlling somatostatin secretion from the gut and pancreas.

Original languageEnglish
Pages (from-to)913-918
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume89
Issue number3
DOIs
StatePublished - Aug 13 1979
Externally publishedYes

Fingerprint

Somatostatin
Rats
Plasmas
Liver
Intravenous Administration
Pancreas
Amino Acids
human PPY protein

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Suppression of somatostatin levels in the hepatic portal and systemic plasma of the rat by synthetic human pancreatic polypeptide. / Arimura, A.; Meyers, C. A.; Case, W. L.; Murphy, W. A.; Schally, Andrew V.

In: Biochemical and Biophysical Research Communications, Vol. 89, No. 3, 13.08.1979, p. 913-918.

Research output: Contribution to journalArticle

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