Suppression of postovulatory gonadotropin levels does not affect corpus luteum function in rhesus monkeys

J. P. Balmaceda, M. R. Borghi, D. H. Coy, Andrew V Schally, R. H. Asch

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21 Citations (Scopus)

Abstract

The exact mechanism(s) of control of corpus luteum function remains unknown. To address the question whether luteinizing hormone (LH) plays an important role, the following experiments were performed in cycling rhesus monkeys. Experiment 1: 10 monkeys were followed for 2 consecutive cycles and ovulation data determined using serum estradiol (E2) measurements and serial laparoscopies. In the second cycle, starting on day 1 after ovulation, the animals received daily administration of a potent inhibitory LHRH analog, [N-Ac-D-Trp1,3, D-p-Cl-Phe1, D-Phe6, D-Ala10]-LH-RH (N = 5) or vehicle (N = 5) until the onset of vaginal bleeding. Serum FSH and LH concentrations declined significantly in animals treated with the antagonist. However, E2 and progesterone (P) levels were not different from vehicle-treated monkeys. Luteal phase length in both groups was unchanged from the control cycle. Experiment 2: the same protocol was followed, adding the administration of hCG in increasing dosages from days 6-10 after ovulation (Day 6 = 30 IU, Day 7 = 60 IU, Day 8 = 90 IU, Day 9 = 180 IU, Day 10 = 360 IU). The increase in serum P concentration was the same for both groups. These results suggest that significant suppression on gonadotropin levels after ovulation does not affect corpus luteum function and that the inhibitory analog does not have a direct effect on the ovary.

Original languageEnglish
Pages (from-to)866-868
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume57
Issue number4
StatePublished - Dec 8 1983
Externally publishedYes

Fingerprint

Corpus Luteum
Luteinizing Hormone
Ovulation
Macaca mulatta
Gonadotropins
Animals
Laparoscopy
Haplorhini
Experiments
Serum
Gonadotropin-Releasing Hormone
Progesterone
Uterine Hemorrhage
Luteal Phase
Estradiol
Ovary

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Suppression of postovulatory gonadotropin levels does not affect corpus luteum function in rhesus monkeys. / Balmaceda, J. P.; Borghi, M. R.; Coy, D. H.; Schally, Andrew V; Asch, R. H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 57, No. 4, 08.12.1983, p. 866-868.

Research output: Contribution to journalArticle

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