Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone

M. V. Nekola; A. Horvath; L. J. Ge; D. H. Coy; A. V. Schally

doi:10.1126/science.6750790

Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone

M. V. Nekola, A. Horvath, L. J. Ge, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antagonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.

Original language	English (US)
Pages (from-to)	160-162
Number of pages	3
Journal	Science
Volume	218
Issue number	4568
DOIs	https://doi.org/10.1126/science.6750790
State	Published - Jan 1 1982
Externally published	Yes

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AU - Coy, D. H.

AU - Schally, A. V.

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