Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone

M. V. Nekola, A. Horvath, L. J. Ge, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antagonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.

Original languageEnglish (US)
Pages (from-to)160-162
Number of pages3
JournalScience
Volume218
Issue number4568
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone'. Together they form a unique fingerprint.

  • Cite this