Abstract
A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antagonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.
Original language | English (US) |
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Pages (from-to) | 160-162 |
Number of pages | 3 |
Journal | Science |
Volume | 218 |
Issue number | 4568 |
DOIs | |
State | Published - Jan 1 1982 |
Externally published | Yes |
ASJC Scopus subject areas
- General