Abstract
A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antagonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 160-162 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 218 |
| Issue number | 4568 |
| DOIs | |
| State | Published - Jan 1 1982 |
| Externally published | Yes |
ASJC Scopus subject areas
- General
Fingerprint Dive into the research topics of 'Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone'. Together they form a unique fingerprint.
Cite this
Nekola, M. V., Horvath, A., Ge, L. J., Coy, D. H., & Schally, A. V. (1982). Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone. Science, 218(4568), 160-162. https://doi.org/10.1126/science.6750790