Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone

M. V. Nekola; A. Horvath; L. J. Ge; D. H. Coy; A. V. Schally

doi:10.1126/science.6750790

Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone

M. V. Nekola, A. Horvath, L. J. Ge, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antagonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.

Original language	English (US)
Pages (from-to)	160-162
Number of pages	3
Journal	Science
Volume	218
Issue number	4568
DOIs	https://doi.org/10.1126/science.6750790
State	Published - Jan 1 1982
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.6750790

Cite this

@article{624baddc315d4f2fa794f8719d1bbb36,

title = "Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone",

abstract = "A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antagonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.",

author = "Nekola, {M. V.} and A. Horvath and Ge, {L. J.} and Coy, {D. H.} and Schally, {A. V.}",

year = "1982",

month = jan,

day = "1",

doi = "10.1126/science.6750790",

language = "English (US)",

volume = "218",

pages = "160--162",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4568",

}

TY - JOUR

T1 - Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone

AU - Nekola, M. V.

AU - Horvath, A.

AU - Ge, L. J.

AU - Coy, D. H.

AU - Schally, A. V.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antagonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.

AB - A synthetic antagonist of luteinizing hormone-releasing hormone blocked ovulation in rats in a dose-dependent manner when given by gavage on the afternoon of proestrus. Ovulation was delayed for at least 1 day in all animals given 2 milligrams of antagonist and in some of the animals treated with 1 or 0.5 milligram. Oral administration of 2 milligrams also blocked the preovulatory surge of luteinizing hormone. This demonstration that antagonists of luteinizing hormone-releasing hormone can have oral antiovulatory activity clearly enhances their therapeutic potential.

UR - http://www.scopus.com/inward/record.url?scp=0019993557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019993557&partnerID=8YFLogxK

U2 - 10.1126/science.6750790

DO - 10.1126/science.6750790

M3 - Article

C2 - 6750790

AN - SCOPUS:0019993557

VL - 218

SP - 160

EP - 162

JO - Science

JF - Science

SN - 0036-8075

IS - 4568

ER -

Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this