Suppression of metabolic accompaniments of phagocytosis by colchicine

Stephen E. Goldfinger, R. Rodney Howell, J. Edwin Seegmiller

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The effect of colchicine on in vitro metabolism of human leukocytes exposed to sodium urate microcrystals was studied. When these cells were preincubated with colchicine at a concentration as low as 2 × 10−6M, suppression of phagocytosis occurred as indicated by: diminution of C14O2 evolution from glucose‐1‐C14, from sodium urate‐6‐C14, and by direct examination of engulfed crystals. The beneficial effect of colchicine on gouty inflammation may result from a suppressive effect on leukocyte function, reducing their ability to perform phagocytosis.

Original languageEnglish (US)
Pages (from-to)1112-1122
Number of pages11
JournalArthritis & Rheumatism
Volume8
Issue number6
DOIs
StatePublished - Dec 1965
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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