Suppression of metabolic accompaniments of phagocytosis by colchicine

Stephen E. Goldfinger, R. Rodney Howell, J. Edwin Seegmiller

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The effect of colchicine on in vitro metabolism of human leukocytes exposed to sodium urate microcrystals was studied. When these cells were preincubated with colchicine at a concentration as low as 2 × 10−6M, suppression of phagocytosis occurred as indicated by: diminution of C14O2 evolution from glucose‐1‐C14, from sodium urate‐6‐C14, and by direct examination of engulfed crystals. The beneficial effect of colchicine on gouty inflammation may result from a suppressive effect on leukocyte function, reducing their ability to perform phagocytosis.

Original languageEnglish (US)
Pages (from-to)1112-1122
Number of pages11
JournalArthritis & Rheumatism
Issue number6
StatePublished - Dec 1965
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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