Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults

Pedro A. Velasquez-Mieyer, P. A. Cowan, Kristopher Arheart, C. K. Buffington, K. A. Spencer, B. E. Connelly, G. W. Cowan, R. H. Lustig

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

PURPOSE: Hyperinsulinemia is a common feature of many obesity syndromes. We investigated whether suppression of insulin secretion, without dietary or exercise intervention, could promote weight loss and alter food intake and preference in obese adults. METHODS: Suppression of insulin secretion was achieved using octreotide-LAR 40 mg IM q28d for 24 weeks in 44 severely obese adults (89% female, 39% minority). Oral glucose tolerance testing was performed before and after treatment, indices of β-cell activity (CIRgp), insulin sensitivity (CISI), and clearance (CP/I AUC) were computed, and leptin levels, 3-day food records and carbohydrate-craving measurements were obtained. DEXA evaluations were performed pre- and post-therapy in an evaluable subgroup. RESULTS: For the entire cohort, significant insulin suppression was achieved with simultaneous improvements in insulin sensitivity, weight loss, and body mass index (BMI). Leptin, fat mass, total caloric intake, and carbohydrate craving significantly decreased. When grouped by BMI response, high responders (HR; ΔBMI <-3 kg/m2) and low responders (LR; ΔBMI between -3 and -0.5) exhibited higher suppression of CIRgp and IAUC than nonresponders (NR; ΔBMI>-0.5). CISI improved and significant declines in leptin and fat mass occurred only in HR and LR. Conversely, both leptin and fat mass increased in NR. Carbohydrate intake was markedly suppressed in HR only, while carbohydrate-craving scores decreased in HR and LR. For the entire cohort, ΔBMI correlated with ΔCISI, Δfat mass, and Δleptin. ΔFat mass also correlated with ΔIAUC and ΔCISI. CONCLUSIONS: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalInternational Journal of Obesity
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

Fingerprint

insulin secretion
Leptin
Insulin Resistance
Weight Loss
leptin
insulin resistance
weight loss
Fats
craving
Insulin
Body Mass Index
body mass index
Carbohydrates
lipids
Energy Intake
carbohydrates
energy intake
Food Preferences
octreotide
Octreotide

Keywords

  • Insulin
  • Obesity
  • Octreotide
  • Somatostatin
  • Weight loss

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Velasquez-Mieyer, P. A., Cowan, P. A., Arheart, K., Buffington, C. K., Spencer, K. A., Connelly, B. E., ... Lustig, R. H. (2003). Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults. International Journal of Obesity, 27(2), 219-226. https://doi.org/10.1038/sj.ijo.802227

Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults. / Velasquez-Mieyer, Pedro A.; Cowan, P. A.; Arheart, Kristopher; Buffington, C. K.; Spencer, K. A.; Connelly, B. E.; Cowan, G. W.; Lustig, R. H.

In: International Journal of Obesity, Vol. 27, No. 2, 01.02.2003, p. 219-226.

Research output: Contribution to journalArticle

Velasquez-Mieyer, PA, Cowan, PA, Arheart, K, Buffington, CK, Spencer, KA, Connelly, BE, Cowan, GW & Lustig, RH 2003, 'Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults', International Journal of Obesity, vol. 27, no. 2, pp. 219-226. https://doi.org/10.1038/sj.ijo.802227
Velasquez-Mieyer, Pedro A. ; Cowan, P. A. ; Arheart, Kristopher ; Buffington, C. K. ; Spencer, K. A. ; Connelly, B. E. ; Cowan, G. W. ; Lustig, R. H. / Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults. In: International Journal of Obesity. 2003 ; Vol. 27, No. 2. pp. 219-226.
@article{5e76dabc251047758974ae9484faff83,
title = "Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults",
abstract = "PURPOSE: Hyperinsulinemia is a common feature of many obesity syndromes. We investigated whether suppression of insulin secretion, without dietary or exercise intervention, could promote weight loss and alter food intake and preference in obese adults. METHODS: Suppression of insulin secretion was achieved using octreotide-LAR 40 mg IM q28d for 24 weeks in 44 severely obese adults (89{\%} female, 39{\%} minority). Oral glucose tolerance testing was performed before and after treatment, indices of β-cell activity (CIRgp), insulin sensitivity (CISI), and clearance (CP/I AUC) were computed, and leptin levels, 3-day food records and carbohydrate-craving measurements were obtained. DEXA evaluations were performed pre- and post-therapy in an evaluable subgroup. RESULTS: For the entire cohort, significant insulin suppression was achieved with simultaneous improvements in insulin sensitivity, weight loss, and body mass index (BMI). Leptin, fat mass, total caloric intake, and carbohydrate craving significantly decreased. When grouped by BMI response, high responders (HR; ΔBMI <-3 kg/m2) and low responders (LR; ΔBMI between -3 and -0.5) exhibited higher suppression of CIRgp and IAUC than nonresponders (NR; ΔBMI>-0.5). CISI improved and significant declines in leptin and fat mass occurred only in HR and LR. Conversely, both leptin and fat mass increased in NR. Carbohydrate intake was markedly suppressed in HR only, while carbohydrate-craving scores decreased in HR and LR. For the entire cohort, ΔBMI correlated with ΔCISI, Δfat mass, and Δleptin. ΔFat mass also correlated with ΔIAUC and ΔCISI. CONCLUSIONS: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.",
keywords = "Insulin, Obesity, Octreotide, Somatostatin, Weight loss",
author = "Velasquez-Mieyer, {Pedro A.} and Cowan, {P. A.} and Kristopher Arheart and Buffington, {C. K.} and Spencer, {K. A.} and Connelly, {B. E.} and Cowan, {G. W.} and Lustig, {R. H.}",
year = "2003",
month = "2",
day = "1",
doi = "10.1038/sj.ijo.802227",
language = "English",
volume = "27",
pages = "219--226",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults

AU - Velasquez-Mieyer, Pedro A.

AU - Cowan, P. A.

AU - Arheart, Kristopher

AU - Buffington, C. K.

AU - Spencer, K. A.

AU - Connelly, B. E.

AU - Cowan, G. W.

AU - Lustig, R. H.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - PURPOSE: Hyperinsulinemia is a common feature of many obesity syndromes. We investigated whether suppression of insulin secretion, without dietary or exercise intervention, could promote weight loss and alter food intake and preference in obese adults. METHODS: Suppression of insulin secretion was achieved using octreotide-LAR 40 mg IM q28d for 24 weeks in 44 severely obese adults (89% female, 39% minority). Oral glucose tolerance testing was performed before and after treatment, indices of β-cell activity (CIRgp), insulin sensitivity (CISI), and clearance (CP/I AUC) were computed, and leptin levels, 3-day food records and carbohydrate-craving measurements were obtained. DEXA evaluations were performed pre- and post-therapy in an evaluable subgroup. RESULTS: For the entire cohort, significant insulin suppression was achieved with simultaneous improvements in insulin sensitivity, weight loss, and body mass index (BMI). Leptin, fat mass, total caloric intake, and carbohydrate craving significantly decreased. When grouped by BMI response, high responders (HR; ΔBMI <-3 kg/m2) and low responders (LR; ΔBMI between -3 and -0.5) exhibited higher suppression of CIRgp and IAUC than nonresponders (NR; ΔBMI>-0.5). CISI improved and significant declines in leptin and fat mass occurred only in HR and LR. Conversely, both leptin and fat mass increased in NR. Carbohydrate intake was markedly suppressed in HR only, while carbohydrate-craving scores decreased in HR and LR. For the entire cohort, ΔBMI correlated with ΔCISI, Δfat mass, and Δleptin. ΔFat mass also correlated with ΔIAUC and ΔCISI. CONCLUSIONS: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.

AB - PURPOSE: Hyperinsulinemia is a common feature of many obesity syndromes. We investigated whether suppression of insulin secretion, without dietary or exercise intervention, could promote weight loss and alter food intake and preference in obese adults. METHODS: Suppression of insulin secretion was achieved using octreotide-LAR 40 mg IM q28d for 24 weeks in 44 severely obese adults (89% female, 39% minority). Oral glucose tolerance testing was performed before and after treatment, indices of β-cell activity (CIRgp), insulin sensitivity (CISI), and clearance (CP/I AUC) were computed, and leptin levels, 3-day food records and carbohydrate-craving measurements were obtained. DEXA evaluations were performed pre- and post-therapy in an evaluable subgroup. RESULTS: For the entire cohort, significant insulin suppression was achieved with simultaneous improvements in insulin sensitivity, weight loss, and body mass index (BMI). Leptin, fat mass, total caloric intake, and carbohydrate craving significantly decreased. When grouped by BMI response, high responders (HR; ΔBMI <-3 kg/m2) and low responders (LR; ΔBMI between -3 and -0.5) exhibited higher suppression of CIRgp and IAUC than nonresponders (NR; ΔBMI>-0.5). CISI improved and significant declines in leptin and fat mass occurred only in HR and LR. Conversely, both leptin and fat mass increased in NR. Carbohydrate intake was markedly suppressed in HR only, while carbohydrate-craving scores decreased in HR and LR. For the entire cohort, ΔBMI correlated with ΔCISI, Δfat mass, and Δleptin. ΔFat mass also correlated with ΔIAUC and ΔCISI. CONCLUSIONS: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.

KW - Insulin

KW - Obesity

KW - Octreotide

KW - Somatostatin

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=0013102988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013102988&partnerID=8YFLogxK

U2 - 10.1038/sj.ijo.802227

DO - 10.1038/sj.ijo.802227

M3 - Article

C2 - 12587002

AN - SCOPUS:0013102988

VL - 27

SP - 219

EP - 226

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 2

ER -