Abstract
PURPOSE: Hyperinsulinemia is a common feature of many obesity syndromes. We investigated whether suppression of insulin secretion, without dietary or exercise intervention, could promote weight loss and alter food intake and preference in obese adults. METHODS: Suppression of insulin secretion was achieved using octreotide-LAR 40 mg IM q28d for 24 weeks in 44 severely obese adults (89% female, 39% minority). Oral glucose tolerance testing was performed before and after treatment, indices of β-cell activity (CIRgp), insulin sensitivity (CISI), and clearance (CP/I AUC) were computed, and leptin levels, 3-day food records and carbohydrate-craving measurements were obtained. DEXA evaluations were performed pre- and post-therapy in an evaluable subgroup. RESULTS: For the entire cohort, significant insulin suppression was achieved with simultaneous improvements in insulin sensitivity, weight loss, and body mass index (BMI). Leptin, fat mass, total caloric intake, and carbohydrate craving significantly decreased. When grouped by BMI response, high responders (HR; ΔBMI <-3 kg/m2) and low responders (LR; ΔBMI between -3 and -0.5) exhibited higher suppression of CIRgp and IAUC than nonresponders (NR; ΔBMI>-0.5). CISI improved and significant declines in leptin and fat mass occurred only in HR and LR. Conversely, both leptin and fat mass increased in NR. Carbohydrate intake was markedly suppressed in HR only, while carbohydrate-craving scores decreased in HR and LR. For the entire cohort, ΔBMI correlated with ΔCISI, Δfat mass, and Δleptin. ΔFat mass also correlated with ΔIAUC and ΔCISI. CONCLUSIONS: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.
| Original language | English |
|---|---|
| Pages (from-to) | 219-226 |
| Number of pages | 8 |
| Journal | International Journal of Obesity |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2003 |
| Externally published | Yes |
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Keywords
- Insulin
- Obesity
- Octreotide
- Somatostatin
- Weight loss
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Public Health, Environmental and Occupational Health
- Endocrinology
- Food Science
- Endocrinology, Diabetes and Metabolism
Cite this
Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults. / Velasquez-Mieyer, Pedro A.; Cowan, P. A.; Arheart, Kristopher; Buffington, C. K.; Spencer, K. A.; Connelly, B. E.; Cowan, G. W.; Lustig, R. H.
In: International Journal of Obesity, Vol. 27, No. 2, 01.02.2003, p. 219-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults
AU - Velasquez-Mieyer, Pedro A.
AU - Cowan, P. A.
AU - Arheart, Kristopher
AU - Buffington, C. K.
AU - Spencer, K. A.
AU - Connelly, B. E.
AU - Cowan, G. W.
AU - Lustig, R. H.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - PURPOSE: Hyperinsulinemia is a common feature of many obesity syndromes. We investigated whether suppression of insulin secretion, without dietary or exercise intervention, could promote weight loss and alter food intake and preference in obese adults. METHODS: Suppression of insulin secretion was achieved using octreotide-LAR 40 mg IM q28d for 24 weeks in 44 severely obese adults (89% female, 39% minority). Oral glucose tolerance testing was performed before and after treatment, indices of β-cell activity (CIRgp), insulin sensitivity (CISI), and clearance (CP/I AUC) were computed, and leptin levels, 3-day food records and carbohydrate-craving measurements were obtained. DEXA evaluations were performed pre- and post-therapy in an evaluable subgroup. RESULTS: For the entire cohort, significant insulin suppression was achieved with simultaneous improvements in insulin sensitivity, weight loss, and body mass index (BMI). Leptin, fat mass, total caloric intake, and carbohydrate craving significantly decreased. When grouped by BMI response, high responders (HR; ΔBMI <-3 kg/m2) and low responders (LR; ΔBMI between -3 and -0.5) exhibited higher suppression of CIRgp and IAUC than nonresponders (NR; ΔBMI>-0.5). CISI improved and significant declines in leptin and fat mass occurred only in HR and LR. Conversely, both leptin and fat mass increased in NR. Carbohydrate intake was markedly suppressed in HR only, while carbohydrate-craving scores decreased in HR and LR. For the entire cohort, ΔBMI correlated with ΔCISI, Δfat mass, and Δleptin. ΔFat mass also correlated with ΔIAUC and ΔCISI. CONCLUSIONS: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.
AB - PURPOSE: Hyperinsulinemia is a common feature of many obesity syndromes. We investigated whether suppression of insulin secretion, without dietary or exercise intervention, could promote weight loss and alter food intake and preference in obese adults. METHODS: Suppression of insulin secretion was achieved using octreotide-LAR 40 mg IM q28d for 24 weeks in 44 severely obese adults (89% female, 39% minority). Oral glucose tolerance testing was performed before and after treatment, indices of β-cell activity (CIRgp), insulin sensitivity (CISI), and clearance (CP/I AUC) were computed, and leptin levels, 3-day food records and carbohydrate-craving measurements were obtained. DEXA evaluations were performed pre- and post-therapy in an evaluable subgroup. RESULTS: For the entire cohort, significant insulin suppression was achieved with simultaneous improvements in insulin sensitivity, weight loss, and body mass index (BMI). Leptin, fat mass, total caloric intake, and carbohydrate craving significantly decreased. When grouped by BMI response, high responders (HR; ΔBMI <-3 kg/m2) and low responders (LR; ΔBMI between -3 and -0.5) exhibited higher suppression of CIRgp and IAUC than nonresponders (NR; ΔBMI>-0.5). CISI improved and significant declines in leptin and fat mass occurred only in HR and LR. Conversely, both leptin and fat mass increased in NR. Carbohydrate intake was markedly suppressed in HR only, while carbohydrate-craving scores decreased in HR and LR. For the entire cohort, ΔBMI correlated with ΔCISI, Δfat mass, and Δleptin. ΔFat mass also correlated with ΔIAUC and ΔCISI. CONCLUSIONS: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.
KW - Insulin
KW - Obesity
KW - Octreotide
KW - Somatostatin
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=0013102988&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0013102988&partnerID=8YFLogxK
U2 - 10.1038/sj.ijo.802227
DO - 10.1038/sj.ijo.802227
M3 - Article
C2 - 12587002
AN - SCOPUS:0013102988
VL - 27
SP - 219
EP - 226
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 2
ER -