Suppression of active collagenase from calcified lapine synovium by Arteparon®

P. B. Halverson, Herman S Cheung, J. Struve, D. J. McCarty

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Collagenase has been implicated in the pathogenesis of several arthropathies. Arteparon® [glycos-aminoglycan (GAG) polysulfate] is a proteinase inhibitor that is being investigated as a therapeutic agent in osteoarthritis. We found that cultures of calcified lapine synovium release collagenase, one tenth of which is already activated. Normal synovium produces no active collagenase. GAG polysulfate suppresses the amount of active collagenase by one half. GAG polysulfate may interfere with the activation process of collagenase.

Original languageEnglish
Pages (from-to)1013-1017
Number of pages5
JournalJournal of Rheumatology
Volume14
Issue number5
StatePublished - Dec 1 1987
Externally publishedYes

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Synovial Membrane
Collagenases
Joint Diseases
Osteoarthritis
Peptide Hydrolases
Arteparon

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Suppression of active collagenase from calcified lapine synovium by Arteparon®. / Halverson, P. B.; Cheung, Herman S; Struve, J.; McCarty, D. J.

In: Journal of Rheumatology, Vol. 14, No. 5, 01.12.1987, p. 1013-1017.

Research output: Contribution to journalArticle

Halverson, PB, Cheung, HS, Struve, J & McCarty, DJ 1987, 'Suppression of active collagenase from calcified lapine synovium by Arteparon®', Journal of Rheumatology, vol. 14, no. 5, pp. 1013-1017.
Halverson, P. B. ; Cheung, Herman S ; Struve, J. ; McCarty, D. J. / Suppression of active collagenase from calcified lapine synovium by Arteparon®. In: Journal of Rheumatology. 1987 ; Vol. 14, No. 5. pp. 1013-1017.
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