Abstract
Collagenase has been implicated in the pathogenesis of several arthropathies. Arteparon® [glycos-aminoglycan (GAG) polysulfate] is a proteinase inhibitor that is being investigated as a therapeutic agent in osteoarthritis. We found that cultures of calcified lapine synovium release collagenase, one tenth of which is already activated. Normal synovium produces no active collagenase. GAG polysulfate suppresses the amount of active collagenase by one half. GAG polysulfate may interfere with the activation process of collagenase.
| Original language | English |
|---|---|
| Pages (from-to) | 1013-1017 |
| Number of pages | 5 |
| Journal | Journal of Rheumatology |
| Volume | 14 |
| Issue number | 5 |
| State | Published - Dec 1 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Suppression of active collagenase from calcified lapine synovium by Arteparon®. / Halverson, P. B.; Cheung, Herman S; Struve, J.; McCarty, D. J.
In: Journal of Rheumatology, Vol. 14, No. 5, 01.12.1987, p. 1013-1017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of active collagenase from calcified lapine synovium by Arteparon®
AU - Halverson, P. B.
AU - Cheung, Herman S
AU - Struve, J.
AU - McCarty, D. J.
PY - 1987/12/1
Y1 - 1987/12/1
N2 - Collagenase has been implicated in the pathogenesis of several arthropathies. Arteparon® [glycos-aminoglycan (GAG) polysulfate] is a proteinase inhibitor that is being investigated as a therapeutic agent in osteoarthritis. We found that cultures of calcified lapine synovium release collagenase, one tenth of which is already activated. Normal synovium produces no active collagenase. GAG polysulfate suppresses the amount of active collagenase by one half. GAG polysulfate may interfere with the activation process of collagenase.
AB - Collagenase has been implicated in the pathogenesis of several arthropathies. Arteparon® [glycos-aminoglycan (GAG) polysulfate] is a proteinase inhibitor that is being investigated as a therapeutic agent in osteoarthritis. We found that cultures of calcified lapine synovium release collagenase, one tenth of which is already activated. Normal synovium produces no active collagenase. GAG polysulfate suppresses the amount of active collagenase by one half. GAG polysulfate may interfere with the activation process of collagenase.
UR - http://www.scopus.com/inward/record.url?scp=0023631263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023631263&partnerID=8YFLogxK
M3 - Article
C2 - 2828615
AN - SCOPUS:0023631263
VL - 14
SP - 1013
EP - 1017
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 5
ER -