Suppression of active collagenase from calcified lapine synovium by Arteparon®

P. B. Halverson; H. S. Cheung; J. Struve; D. J. McCarty

Suppression of active collagenase from calcified lapine synovium by Arteparon®

P. B. Halverson, H. S. Cheung, J. Struve, D. J. McCarty

Research output: Contribution to journal › Article › peer-review

Abstract

Collagenase has been implicated in the pathogenesis of several arthropathies. Arteparon® [glycos-aminoglycan (GAG) polysulfate] is a proteinase inhibitor that is being investigated as a therapeutic agent in osteoarthritis. We found that cultures of calcified lapine synovium release collagenase, one tenth of which is already activated. Normal synovium produces no active collagenase. GAG polysulfate suppresses the amount of active collagenase by one half. GAG polysulfate may interfere with the activation process of collagenase.

Original language	English (US)
Pages (from-to)	1013-1017
Number of pages	5
Journal	Journal of Rheumatology
Volume	14
Issue number	5
State	Published - Dec 1 1987
Externally published	Yes

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

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AU - Halverson, P. B.

AU - Cheung, H. S.

AU - Struve, J.

AU - McCarty, D. J.

PY - 1987/12/1

Y1 - 1987/12/1

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AB - Collagenase has been implicated in the pathogenesis of several arthropathies. Arteparon® [glycos-aminoglycan (GAG) polysulfate] is a proteinase inhibitor that is being investigated as a therapeutic agent in osteoarthritis. We found that cultures of calcified lapine synovium release collagenase, one tenth of which is already activated. Normal synovium produces no active collagenase. GAG polysulfate suppresses the amount of active collagenase by one half. GAG polysulfate may interfere with the activation process of collagenase.

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Suppression of active collagenase from calcified lapine synovium by Arteparon®

Abstract

ASJC Scopus subject areas

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