Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice

S. Sakamoto, M. Mizuno, K. Sawaki, H. Kudo, Noriyuki Kasahara, S. Suzuki, T. Mori, H. Nagasawa

Research output: Contribution to journalArticle

Abstract

It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.

Original languageEnglish (US)
Pages (from-to)1291-1294
Number of pages4
JournalAnticancer Research
Volume12
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Tegafur
Uracil
Human Mammary Glands
Breast
DNA
Oral Administration
Breast Neoplasms
Enzymes

Keywords

  • 5-fluorouracil
  • DNA synthesizing enzymes
  • Hyperplastic alveolar nodule (HAN)
  • Mammary gland
  • Mice

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice. / Sakamoto, S.; Mizuno, M.; Sawaki, K.; Kudo, H.; Kasahara, Noriyuki; Suzuki, S.; Mori, T.; Nagasawa, H.

In: Anticancer Research, Vol. 12, No. 4, 1992, p. 1291-1294.

Research output: Contribution to journalArticle

Sakamoto, S. ; Mizuno, M. ; Sawaki, K. ; Kudo, H. ; Kasahara, Noriyuki ; Suzuki, S. ; Mori, T. ; Nagasawa, H. / Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice. In: Anticancer Research. 1992 ; Vol. 12, No. 4. pp. 1291-1294.
@article{5c5ee6825b5c40b9a313087df67e7d15,
title = "Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice",
abstract = "It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT{\circledR}) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT{\circledR} for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT{\circledR} reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.",
keywords = "5-fluorouracil, DNA synthesizing enzymes, Hyperplastic alveolar nodule (HAN), Mammary gland, Mice",
author = "S. Sakamoto and M. Mizuno and K. Sawaki and H. Kudo and Noriyuki Kasahara and S. Suzuki and T. Mori and H. Nagasawa",
year = "1992",
language = "English (US)",
volume = "12",
pages = "1291--1294",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "4",

}

TY - JOUR

T1 - Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice

AU - Sakamoto, S.

AU - Mizuno, M.

AU - Sawaki, K.

AU - Kudo, H.

AU - Kasahara, Noriyuki

AU - Suzuki, S.

AU - Mori, T.

AU - Nagasawa, H.

PY - 1992

Y1 - 1992

N2 - It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.

AB - It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.

KW - 5-fluorouracil

KW - DNA synthesizing enzymes

KW - Hyperplastic alveolar nodule (HAN)

KW - Mammary gland

KW - Mice

UR - http://www.scopus.com/inward/record.url?scp=0026806249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026806249&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 1291

EP - 1294

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 4

ER -