Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice

S. Sakamoto, M. Mizuno, K. Sawaki, H. Kudo, N. Kasahara, S. Suzuki, T. Mori, H. Nagasawa

Research output: Contribution to journalArticlepeer-review

Abstract

It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.

Original languageEnglish (US)
Pages (from-to)1291-1294
Number of pages4
JournalAnticancer research
Volume12
Issue number4
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • 5-fluorouracil
  • DNA synthesizing enzymes
  • Hyperplastic alveolar nodule (HAN)
  • Mammary gland
  • Mice

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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