Abstract
It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1291-1294 |
| Number of pages | 4 |
| Journal | Anticancer research |
| Volume | 12 |
| Issue number | 4 |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
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Keywords
- 5-fluorouracil
- DNA synthesizing enzymes
- Hyperplastic alveolar nodule (HAN)
- Mammary gland
- Mice
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Sakamoto, S., Mizuno, M., Sawaki, K., Kudo, H., Kasahara, N., Suzuki, S., Mori, T., & Nagasawa, H. (1992). Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice. Anticancer research, 12(4), 1291-1294.