Abstract
It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.
Original language | English (US) |
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Pages (from-to) | 1291-1294 |
Number of pages | 4 |
Journal | Anticancer research |
Volume | 12 |
Issue number | 4 |
State | Published - Jan 1 1992 |
Externally published | Yes |
Keywords
- 5-fluorouracil
- DNA synthesizing enzymes
- Hyperplastic alveolar nodule (HAN)
- Mammary gland
- Mice
ASJC Scopus subject areas
- Oncology
- Cancer Research