Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice

It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.