Abstract
It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1291-1294 |
| Number of pages | 4 |
| Journal | Anticancer Research |
| Volume | 12 |
| Issue number | 4 |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- 5-fluorouracil
- DNA synthesizing enzymes
- Hyperplastic alveolar nodule (HAN)
- Mammary gland
- Mice
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice. / Sakamoto, S.; Mizuno, M.; Sawaki, K.; Kudo, H.; Kasahara, Noriyuki; Suzuki, S.; Mori, T.; Nagasawa, H.
In: Anticancer Research, Vol. 12, No. 4, 1992, p. 1291-1294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression by 1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice
AU - Sakamoto, S.
AU - Mizuno, M.
AU - Sawaki, K.
AU - Kudo, H.
AU - Kasahara, Noriyuki
AU - Suzuki, S.
AU - Mori, T.
AU - Nagasawa, H.
PY - 1992
Y1 - 1992
N2 - It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.
AB - It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5 fluorouracil and uracil (UFT®) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT® for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT® reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.
KW - 5-fluorouracil
KW - DNA synthesizing enzymes
KW - Hyperplastic alveolar nodule (HAN)
KW - Mammary gland
KW - Mice
UR - http://www.scopus.com/inward/record.url?scp=0026806249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026806249&partnerID=8YFLogxK
M3 - Article
VL - 12
SP - 1291
EP - 1294
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 4
ER -