TY - JOUR
T1 - Supplementation with selenium-enriched yeast attenuates brain metastatic growth
AU - Wrobel, Jagoda K.
AU - Seelbach, Melissa J.
AU - Chen, Lei
AU - Power, Ronan F.
AU - Toborek, Michal
N1 - Funding Information:
This study was supported by the grants from the National Institutes of Health CA133257 and ES07380 and from Alltech. Jagoda K. Wrobel, Melissa J. Seelbach, and Lei Chen equally contributed to this article.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Metastases are the leading cause of cancer mortality and their development may be affected by diet. The aim of this study was to compare the effects of dietary supplementation with different selenium (Se) compounds on the dynamics of brain metastasis development in a novel mouse model. Mice were fed experimental diets enriched (1 mg/kg) with sodium selenite (Se-S), seleno-1-methionine (Se-Meth), a yeast-derived organic form of selenium (Se-Yeast), or a control diet (Se < 0.05 mg/kg) for 20 wk. At the end of the feeding period, animals were injected with luciferase-tagged K1735 (K1735-Luc) melanoma cells into the brain vasculature. The development of brain metastatic tumors was monitored for 2 wk following injection. Mice bearing brain metastatic tumors and fed Se-Yeast- or Se-S-enriched diets displayed a higher survival rate compared with other experimental and control groups. Importantly, Se-Yeast supplementation decreased the growth of brain metastatic tumors as determined by the measurement of the intensity of the bioluminescent signal emitted by K1735-Luc cells upon reaction with luciferin. Different chemical forms of Se have distinct effects on the development of brain metastases. Organic Se in the form of Se-Yeast may be a valuable agent in suppression of brain metastatic disease.
AB - Metastases are the leading cause of cancer mortality and their development may be affected by diet. The aim of this study was to compare the effects of dietary supplementation with different selenium (Se) compounds on the dynamics of brain metastasis development in a novel mouse model. Mice were fed experimental diets enriched (1 mg/kg) with sodium selenite (Se-S), seleno-1-methionine (Se-Meth), a yeast-derived organic form of selenium (Se-Yeast), or a control diet (Se < 0.05 mg/kg) for 20 wk. At the end of the feeding period, animals were injected with luciferase-tagged K1735 (K1735-Luc) melanoma cells into the brain vasculature. The development of brain metastatic tumors was monitored for 2 wk following injection. Mice bearing brain metastatic tumors and fed Se-Yeast- or Se-S-enriched diets displayed a higher survival rate compared with other experimental and control groups. Importantly, Se-Yeast supplementation decreased the growth of brain metastatic tumors as determined by the measurement of the intensity of the bioluminescent signal emitted by K1735-Luc cells upon reaction with luciferin. Different chemical forms of Se have distinct effects on the development of brain metastases. Organic Se in the form of Se-Yeast may be a valuable agent in suppression of brain metastatic disease.
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U2 - 10.1080/01635581.2013.775315
DO - 10.1080/01635581.2013.775315
M3 - Article
C2 - 23659448
AN - SCOPUS:84877974311
VL - 65
SP - 563
EP - 570
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 4
ER -
