Superparamagnetic nanoparticles as a powerful systems biology characterization tool in the physiological context

Jatuporn Salaklang, Benedikt Steitz, Andrija Finka, Conlin P. O'Neil, Marc Moniatte, André J. Van Der Vlies, Todd D. Giorgio, Heinrich Hofmann, Jeffrey A. Hubbell, Alke Petri-Fink

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Spying on SPIONs: Superparamagnetic iron oxide nanoparticles (SPIONs) bearing a mitochondrial targeting peptide (MTP), a cyclic RGD peptide for internalization (cRGD), and a fluorophore for tracking can be targeted to mitochondria. After magnetic isolation from the cells, 48 proteins are identified by mass spectrometry to be interacting with the MTP-cRGD-SPIONs in a network that consists of 308 interactions (see picture). (Figure Presented).

Original languageEnglish (US)
Pages (from-to)7857-7860
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number41
DOIs
StatePublished - Sep 29 2008
Externally publishedYes

Keywords

  • Magnetic properties
  • Mitochondria
  • Nanoparticles
  • Peptides
  • Proteins

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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    Salaklang, J., Steitz, B., Finka, A., O'Neil, C. P., Moniatte, M., Van Der Vlies, A. J., Giorgio, T. D., Hofmann, H., Hubbell, J. A., & Petri-Fink, A. (2008). Superparamagnetic nanoparticles as a powerful systems biology characterization tool in the physiological context. Angewandte Chemie - International Edition, 47(41), 7857-7860. https://doi.org/10.1002/anie.200800357