Superficial chest wall recurrences of breast cancer: Prognostic treatment factors for combined radiation therapy and hyperthermia

H. M. Seegenschmiedt, U. L. Karlsson, R. Sauer, L. W. Brady, M. Herbst, B. E. Amendola, A. M. Markoe, S. A. Fisher, B. Micaily

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Forty-nine patients with chest wall recurrences of breast carcinoma received radiation therapy and 915-MHz microwave hyperthermia for 95 lesions. Follow-up ranged from 3 to 39 months, with five patients dying before 6 months follow-up. At 1 month follow-up, 49 (52%) of 95 lesions showed complete response; 28 (29%), partial response; and 18 (19%), no change. At 6 or more months follow-up, 54 (67%) of 81 lesions demonstrated local control; 10 (12%), partial response; six (7%), no change; and 11 (14%), local-regional recurrences. Superficial blisters occurred in 24 (25%) of 95 lesions, whereas long-term complications (deep necrosis, subcutaneous burns) occurred in seven (7%) lesions. Relapse occurred in 16 (17%) lesions, seven after initial complete response and nine after partial response. Several prognostic treatment factors were identified: applied radiation dose (>30 Gy, P<.01), size of tumor (<6 cm diameter, P<.001), minimum tumor temperature (>41°C, P<.001), and status of disease (M0 or M1 vs M2, P<.001). Treatment complications were correlated with maximum temperatures (>45°C, P<.001). In summary the palliative treatment concept proved to be safe and effective.

Original languageEnglish (US)
Pages (from-to)551-558
Number of pages8
JournalRadiology
Volume173
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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