TY - JOUR
T1 - Superficial chest wall recurrences of breast cancer
T2 - Prognostic treatment factors for combined radiation therapy and hyperthermia
AU - Seegenschmiedt, H. M.
AU - Karlsson, U. L.
AU - Sauer, R.
AU - Brady, L. W.
AU - Herbst, M.
AU - Amendola, B. E.
AU - Markoe, A. M.
AU - Fisher, S. A.
AU - Micaily, B.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - Forty-nine patients with chest wall recurrences of breast carcinoma received radiation therapy and 915-MHz microwave hyperthermia for 95 lesions. Follow-up ranged from 3 to 39 months, with five patients dying before 6 months follow-up. At 1 month follow-up, 49 (52%) of 95 lesions showed complete response; 28 (29%), partial response; and 18 (19%), no change. At 6 or more months follow-up, 54 (67%) of 81 lesions demonstrated local control; 10 (12%), partial response; six (7%), no change; and 11 (14%), local-regional recurrences. Superficial blisters occurred in 24 (25%) of 95 lesions, whereas long-term complications (deep necrosis, subcutaneous burns) occurred in seven (7%) lesions. Relapse occurred in 16 (17%) lesions, seven after initial complete response and nine after partial response. Several prognostic treatment factors were identified: applied radiation dose (>30 Gy, P<.01), size of tumor (<6 cm diameter, P<.001), minimum tumor temperature (>41°C, P<.001), and status of disease (M0 or M1 vs M2, P<.001). Treatment complications were correlated with maximum temperatures (>45°C, P<.001). In summary the palliative treatment concept proved to be safe and effective.
AB - Forty-nine patients with chest wall recurrences of breast carcinoma received radiation therapy and 915-MHz microwave hyperthermia for 95 lesions. Follow-up ranged from 3 to 39 months, with five patients dying before 6 months follow-up. At 1 month follow-up, 49 (52%) of 95 lesions showed complete response; 28 (29%), partial response; and 18 (19%), no change. At 6 or more months follow-up, 54 (67%) of 81 lesions demonstrated local control; 10 (12%), partial response; six (7%), no change; and 11 (14%), local-regional recurrences. Superficial blisters occurred in 24 (25%) of 95 lesions, whereas long-term complications (deep necrosis, subcutaneous burns) occurred in seven (7%) lesions. Relapse occurred in 16 (17%) lesions, seven after initial complete response and nine after partial response. Several prognostic treatment factors were identified: applied radiation dose (>30 Gy, P<.01), size of tumor (<6 cm diameter, P<.001), minimum tumor temperature (>41°C, P<.001), and status of disease (M0 or M1 vs M2, P<.001). Treatment complications were correlated with maximum temperatures (>45°C, P<.001). In summary the palliative treatment concept proved to be safe and effective.
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U2 - 10.1148/radiology.173.2.2477869
DO - 10.1148/radiology.173.2.2477869
M3 - Article
C2 - 2477869
AN - SCOPUS:0024341951
VL - 173
SP - 551
EP - 558
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -