Superantigen-Mediated Deletion of Specific T Cell Receptor Vβ Subsets in the SCID-hu Thy/ Liv Mouse Is Induced by Staphylococcal Enterotoxin B, but Not HIV-I

Krishna V. Komanduri, Marie Danielle Salha, Rafick Pierre Sékaly, Joseph M. McCune

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Infection by HIV-1 has been associated with perturbations in the TCR Vβ repertoire, suggesting the involvement of a superantigen. Among the hallmarks of superantigens is the capacity to delete T cells bearing specific TCR Vβ families in the developing thymus. To verify the presence of a superantigen in HIV-1, we analyzed the SCID-hu Thy/Liv TCR Vβ repertoire within CD4+CD8+, CD4+CD8-, or CD4-CD8+ thymocytes subsets by flow cytometry using a panel of Abs recognizing about 60% of the TCR repertoire following injection of SEB or infection by two different HIV-1 isolates. Seven days following SEB injection, thymocyte subsets bearing TCR Vβ3, Vβ12, Vβ17, and Vβ20, but not Vβ5 or Vβ8, were deleted relative to mock-injected mice. In contrast, no changes were observed in the TCR Vβ repertoire in CD4+CD8+, CD4+CD8-, or CD4-CD8+ thymocyte subsets after infection with HIV-1. The T cell depletion caused by HIV-1 infection is most likely not mediated by an HIV-encoded superantigen.

Original languageEnglish (US)
Pages (from-to)544-549
Number of pages6
JournalJournal of Immunology
Volume158
Issue number2
StatePublished - Jan 15 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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