[3H]PCP-3-OH and (+)[3H]SKF 10047 binding sites in rat brain membranes: evidence of multiplicity

Yossef Itzhak

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Specific binding of one of the most potent analogs of phencyclidine (PCP), [3H]PCP-3-OH, in rat brain membranes revealed the labeling of high (Kd = 0.5 nM) and low (Kd = 16 nM) affinity binding sites. (+)SKF 10047 potently inhibited high, but not low, affinity [3H]PCP-3-OH binding. (+)[3H]SKF 10047 apparently labeled the high affinity PCP-3-OH binding site and also an additional site, sensitive to haloperidol, which is distinct from the two sites labeled by [3H]PCP-3-OH.

Original languageEnglish (US)
Pages (from-to)231-234
Number of pages4
JournalEuropean Journal of Pharmacology
Volume136
Issue number2
DOIs
StatePublished - Apr 14 1987

Keywords

  • (+)[H]SKF 10047
  • Affinity binding sites (high and low)
  • Haloperidol
  • Phencyclidine
  • [H]PCP-3-OH

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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