1H spectroscopic imaging of rat brain at 7 tesla

E. J. Fernandez, A. A. Maudsley, T. Higuchi, M. W. Weiner

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

1H magnetic resonance spectroscopic imaging has been used to obtain metabolite maps of the rat brain. The spin-echo-based technique has been evaluated with respect to water and lipid suppression and sensitivity. Metabolite maps were constructed for choline, creatine + phosphocreatine, amino acids, N-acetyl aspartate, and lactate. A spatial resolution of 3 x 3 mm (in plane) with 7-mm-thick slices was achieved routinely in 60-min (16 x 16 phase encodings) acquisitions. For higher intensity resonances, metabolite maps could be constructed in as little as 10 min. Results from phantoms and from rats under normal and focal ischemia conditions are presented.

Original languageEnglish (US)
Pages (from-to)107-119
Number of pages13
JournalMagnetic Resonance in Medicine
Volume25
Issue number1
DOIs
StatePublished - May 1992
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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