1H spectroscopic imaging of rat brain at 7 tesla

E. J. Fernandez, Andrew A Maudsley, T. Higuchi, M. W. Weiner

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

1H magnetic resonance spectroscopic imaging has been used to obtain metabolite maps of the rat brain. The spin-echo-based technique has been evaluated with respect to water and lipid suppression and sensitivity. Metabolite maps were constructed for choline, creatine + phosphocreatine, amino acids, N-acetyl aspartate, and lactate. A spatial resolution of 3 x 3 mm (in plane) with 7-mm-thick slices was achieved routinely in 60-min (16 x 16 phase encodings) acquisitions. For higher intensity resonances, metabolite maps could be constructed in as little as 10 min. Results from phantoms and from rats under normal and focal ischemia conditions are presented.

Original languageEnglish
Pages (from-to)107-119
Number of pages13
JournalMagnetic Resonance in Medicine
Volume25
Issue number1
DOIs
StatePublished - Jun 5 1992
Externally publishedYes

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Neuroimaging
Phosphocreatine
Creatine
Choline
Lactic Acid
Ischemia
Magnetic Resonance Imaging
Lipids
Amino Acids
Water
Brain
N-acetylaspartate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

1H spectroscopic imaging of rat brain at 7 tesla. / Fernandez, E. J.; Maudsley, Andrew A; Higuchi, T.; Weiner, M. W.

In: Magnetic Resonance in Medicine, Vol. 25, No. 1, 05.06.1992, p. 107-119.

Research output: Contribution to journalArticle

Fernandez, E. J. ; Maudsley, Andrew A ; Higuchi, T. ; Weiner, M. W. / 1H spectroscopic imaging of rat brain at 7 tesla. In: Magnetic Resonance in Medicine. 1992 ; Vol. 25, No. 1. pp. 107-119.
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