1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS

J. Suhy, W. D. Rooney, D. E. Goodkin, A. A. Capizzano, B. J. Soher, Andrew A Maudsley, E. Waubant, P. B. Andersson, M. W. Weiner

Research output: Contribution to journalArticle

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Abstract

Objective: To compare brain metabolite levels in patients with primary progressive (PP) and relapsing remitting (RR) MS and controls. Hypotheses: (1) creatine (Cr), a putative marker of gliosis, is elevated and N-acetylaspartate (NAA), a putative marker of axonal density and functional integrity, is reduced in PPMS lesions and normal appearing white matter (NAWM) compared to control white matter; (2) The pattern of metabolite change in PPMS is different than in RRMS. Methods: MRI and proton magnetic resonance spectroscopic imaging (1H MRSI) were collected from 15 PPMS patients, 13 RRMS patients, and 20 controls. Results: Cr was increased in PPMS NAWM compared to controls (P=0.035), and compared to RRMS NAWM (P=0.038). Cr was increased in focal MRI lesions from PPMS compared to lesions from RRMS (P=0.044) and compared to control white matter (P=0.041). NAA was similarly reduced in PPMS and RRMS NAWM compared to control. NAA was similarly reduced in PPMS and RRMS lesions, compared to control white matter. Conclusions: Creatine is higher in PPMS than RRMS NAWM and focal lesions. This observation is consistent with the notion that progressive disability in PPMS reflects increased gliosis and axonal loss whereas disability in RRMS reflects the cumulative effects of acute inflammatory lesions and axonal loss.

Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalMultiple Sclerosis
Volume6
Issue number3
StatePublished - Jun 1 2000
Externally publishedYes

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Creatine
Gliosis
White Matter
Protons
Magnetic Resonance Imaging
Brain
N-acetylaspartate

Keywords

  • Magnetic resonance spectroscopy
  • Primary progressive multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Suhy, J., Rooney, W. D., Goodkin, D. E., Capizzano, A. A., Soher, B. J., Maudsley, A. A., ... Weiner, M. W. (2000). 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. Multiple Sclerosis, 6(3), 148-155.

1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. / Suhy, J.; Rooney, W. D.; Goodkin, D. E.; Capizzano, A. A.; Soher, B. J.; Maudsley, Andrew A; Waubant, E.; Andersson, P. B.; Weiner, M. W.

In: Multiple Sclerosis, Vol. 6, No. 3, 01.06.2000, p. 148-155.

Research output: Contribution to journalArticle

Suhy, J, Rooney, WD, Goodkin, DE, Capizzano, AA, Soher, BJ, Maudsley, AA, Waubant, E, Andersson, PB & Weiner, MW 2000, '1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS', Multiple Sclerosis, vol. 6, no. 3, pp. 148-155.
Suhy J, Rooney WD, Goodkin DE, Capizzano AA, Soher BJ, Maudsley AA et al. 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. Multiple Sclerosis. 2000 Jun 1;6(3):148-155.
Suhy, J. ; Rooney, W. D. ; Goodkin, D. E. ; Capizzano, A. A. ; Soher, B. J. ; Maudsley, Andrew A ; Waubant, E. ; Andersson, P. B. ; Weiner, M. W. / 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. In: Multiple Sclerosis. 2000 ; Vol. 6, No. 3. pp. 148-155.
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AU - Goodkin, D. E.

AU - Capizzano, A. A.

AU - Soher, B. J.

AU - Maudsley, Andrew A

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