1H MRS of basal ganglia and thalamus in amyotrophic lateral sclerosis

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Previous studies have evaluated motor and extramotor cerebral cortical regions in patients with amyotrophic lateral sclerosis (ALS) using 1H MRS, but none have evaluated the thalamus or basal ganglia. The objective of this exploratory study was to evaluate the subclinical involvement of the basal ganglia and thalamus in patients with ALS using 1H MRS. Fourteen patients (52±7 years) with sporadic definite ALS and 17 age-matched controls were studied using volumetric MRSI on a 3-T scanner. The concentration of the metabolites N-acetylaspartate (NAA), choline (Cho) and their ratio (NAA/Cho) were obtained bilaterally from the basal ganglia (lentiform nucleus, caudate) and thalamus. The maximum rates of finger and foot tap and lip and tongue movements were obtained to assess extrapyramidal and pyramidal tract function. In patients with ALS, relative to controls, the NAA concentration was significantly lower (p<0.02) in the basal ganglia and thalamus, and the Cho concentration was higher (p<0.01) in these structures, except in the caudate (p=0.04). Correspondingly, the NAA/Cho ratio was significantly lower (p<0.01) in these structures, except in the caudate (p=0.03), in patients than in controls. There were mild to strong correlations (r=0.4-0.7) between the metabolites of the basal ganglia and finger tap, foot tap and lip and tongue movement rates. In conclusion, decreased NAA in the basal ganglia and thalamus and increased Cho and decreased NAA/Cho in the lentiform nucleus and thalamus are indicative of neuronal loss or dysfunction and alterations in choline-containing membranes in these structures.

Original languageEnglish
Pages (from-to)1270-1276
Number of pages7
JournalNMR in Biomedicine
Volume24
Issue number10
DOIs
StatePublished - Dec 1 2011

Fingerprint

Amyotrophic Lateral Sclerosis
Choline
Basal Ganglia
Thalamus
Corpus Striatum
Metabolites
Lip
Tongue
Extrapyramidal Tracts
Fingers
Foot
Pyramidal Tracts
Proton Magnetic Resonance Spectroscopy
N-acetylaspartate
Membranes

Keywords

  • Amyotrophic lateral sclerosis
  • Basal ganglia
  • Extramotor
  • MRS
  • Thalamus

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

1H MRS of basal ganglia and thalamus in amyotrophic lateral sclerosis. / Sharma, Khema R; Saigal, Gaurav; Maudsley, Andrew A; Govind, Varan.

In: NMR in Biomedicine, Vol. 24, No. 10, 01.12.2011, p. 1270-1276.

Research output: Contribution to journalArticle

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